How can I get all the proteins involved in a given disease ?
Last modified April 8, 2008
Information relevant to diseases associated with a given protein are found in the subsection 'Involvement in disease' of the General annotation section. The information given (including the disease name) is consistent with the literature and the OMIM database.
You can use two methods to search proteins associated with a given disease.
Search for proteins using the query builder:
- Search in:
Protein Knowledgebase (UniProtKB) - Click on Fields ยป to open the query builder
- Field:
General annotation - Topic:
Involvement in disease - Type the name of a disease in the Term box (e.g. 'hemolytic anemia')
- Click on Add & Search
- result
Browse by keyword:
Some proteins involved in a specific non-monogenic disease are associated with specialized 'disease' keywords (Diabetes mellitus, Cataract, Alzheimer disease...)
- Go to the keywords page
- Click on the
keyword category 'Disease' - Browse the keywords navigation table
- Click on your chosen term, e.g. Diabetes mellitus
- Click on
'UniProtKB'to view corresponding proteins (result)
Note 1: Currently, these keywords apply mainly to non-monogenic diseases.
Note 2: The keyword 'Disease mutation' is used for proteins with at least one disease-associated variant. Variants are described in the sequence annotation section of a protein entry.
