Release 9.2

All known human G protein-coupled receptor proteins in UniProtKB/Swiss-Prot

The Human Proteome Initiative (HPI) aims to annotate all known human protein sequences, as well as their mammalian orthologs. The G protein-coupled receptor proteins (GPCRs), also known as seven transmembrane receptors (7TM receptors) form one of the largest proteins family in mammalian genomes. These proteins are involved in all types of stimulus-response pathways, from intercellular communication to physiological senses, including taste, smell, and vision (opsins receptors). Many diseases are linked to GPCRs and half of the drug products by the pharmaceutical industry are targeted against GPCRs. A special emphasis has been given to this family in the HPI project.

In the current release, all known and potential human G protein-coupled receptor protein are annotated and integrated in UniProtKB/Swiss-Prot. 775 human GPCRs are now available in our knowledgebase. About half of all GPCRs are presumed to be involved in the sense of smell. For the remaining half, the active ligand has been documented when available, but about 20% of human GPCRs are still orphans. Most of mouse and rat orthologs have been annotated.

All G protein-coupled receptor proteins annotated in UniProtKB/Swiss-Prot are classified by family and listed in the file 7tmrlist.txt.