Unreviewed, UniProtKB/TrEMBL A0A189 (A0A189_9INFA)

Names and origin

Protein names

Submitted name:
    Haemagglutinin EMBL ABJ90226.2

Gene names

Name:

HA EMBL ABJ90226.2

Organism

Influenza A virus (A/ostrich/Italy/2332/00(H7N1)) EMBL ABJ90226.2

Taxonomic identifier

338858 [NCBI]

Taxonomic lineage

Viruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A

Protein attributes

Sequence length	564 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. Spearmint SPM013829 Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore By similarity. RuleBase RU003324V0
Subunit structure	Homotrimer of disulfide-linked HA1-HA2. Spearmint SPM013829 Homotrimer of disulfide-linked HA1-HA2 By similarity. RuleBase RU003324V0
Subcellular location	Virion membrane. Spearmint SPM013829
Sequence similarities	Belongs to the influenza viruses hemagglutinin family. RuleBase RU003324V0

Ontologies

Keywords
Biological process	Fusion protein Spearmint SPM013829
Cellular component	Cell membrane Spearmint SPM013829 Envelope protein RuleBase RU003324V0 Spearmint SPM013829 Membrane Virion
Domain	Transmembrane Spearmint SPM013829
Molecular function	Hemagglutinin RuleBase RU003324V0 Spearmint SPM013829
Gene Ontology (GO)
Biological process	viral envelope fusion with host membrane Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW viral envelope Inferred from electronic annotation. Source: InterPro
Molecular function	host cell surface receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0A189-1 [UniParc]. Last modified February 20, 2007. Version 2. Checksum: 2FE40DF7367AF132	FASTA	564	62,741
	10 20 30 40 50 60 MNTQILVFAL VAIIPTNADK ICLGHHAVSN GTKVNTLTER GVEVVNATET VERTNVPRIC 70 80 90 100 110 120 SKGKRTVDLG QCGLLGIITG PPQCDQFLEF SADLIIERRE GSDVCYPGKF VNEEALRQIL 130 140 150 160 170 180 RESGGIDKEA MGFTYSGIRT NGTTSTCRRS GSSFYAEMKW LLSNTDNAAF PQMTKSYKNT 190 200 210 220 230 240 RKDPALIIWG IHHSGSTTEQ TKLYGSGNKL ITVGSSNYQQ SFVPSPGERP QVNGQSGRID 250 260 270 280 290 300 FHWLMLNPND TITFSFNGAF IAPNRASFLR GKSMGIQSGV QVDANCEGDC YHSGGTIISN 310 320 330 340 350 360 LPFQNINSRA VGXCPRYVKQ ESLLLATGMK NVPEIPKGSR VRRGLFGAIA GFIENGWEGL 370 380 390 400 410 420 IDGWYGFRHQ NAQGEGTAAD YKSTQSAIDQ VTGKLNRLIE KTNQQFELID NEFTEVEKQI 430 440 450 460 470 480 GNVINWTRDS MTEVWSYNAE LLVAMENQHT IDLTDSEMNK LYERVKRLLR ENAEEDGTGC 490 500 510 520 530 540 FEIFHKCDDD CMASIRNNTY DHSKYREEAM QNRIQIDPVK LSSGYKDVIL WFSFGASCFI 550 560 LLAIAMGLVF ICVRNGNMRC TICI

References

[1]

"Pneumo- and neurotropism of avian origin Italian highly pathogenic avian influenza H7N1 isolates in experimentally infected mice." Rigoni M., Shinya K., Toffan A., Milani A., Bettini F., Kawaoka Y., Cattoli G., Capua I. Virology 364:28-35(2007) [PubMed: 17408714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: A/ostrich/Italy/2332/00 EMBL ABJ90226.2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ991304 Viral cRNA. Translation: ABJ90226.2. DQ991312 Viral cRNA. Translation: ABJ90237.2.
3D structure databases
SMR	A0A189. Positions 21-334.
ModBase	Search...
Family and domain databases
InterPro	IPR000149. Hemagglutn_influenz_HA1. IPR001364. Hemagglutn_influenz_HA1/HA2. IPR013829. Hemagglutn_stalk. [Graphical view]
Gene3D	G3DSA:3.90.20.10. Haemagglutn_stalk. 2 hits.
Pfam	PF00509. Hemagglutinin. 1 hit. [Graphical view]
PRINTS	PR00330. HEMAGGLUTN1. PR00329. HEMAGGLUTN12.
ProDom	PD000225. Hemagglutn. 1 hit. [Graphical view] [Entries sharing at least one domain]

Entry information

Entry name

A0A189_9INFA

Accession

Primary (citable) accession number: A0A189
Secondary accession number(s): A0A1A0

Entry history

Integrated into UniProtKB/TrEMBL:	November 14, 2006
Last sequence update:	February 20, 2007
Last modified:	September 23, 2008
This is version 17 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)