Unreviewed, UniProtKB/TrEMBL A0A1C9 (A0A1C9_9INFA)

Names and origin

Protein names

Submitted name:
    Matrix protein 1 EMBL ABJ90272.2

Gene names

Name:

M1 EMBL ABJ90272.2

Organism

Influenza A virus (A/ostrich/Italy/984/00(H7N1)) EMBL ABJ90272.2

Taxonomic identifier

338859 [NCBI]

Taxonomic lineage

Viruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function

Determines the virion's shape: spherical or filamentous. Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology. Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms By similarity. Spearmint SPM013188 Plays critical roles in virus replication, from virus entry and uncoating to assembly and budding of the virus particle. M1 binding to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral transcription. Interaction of viral NEP with M1-RNP is thought to promote nuclear export of the complex, which is targeted to the virion assembly site at the apical plasma membrane in polarized epithelial cells. Interactions with NA and HA may bring M1, a non-raft-associated protein, into lipid rafts. Forms a continuous shell on the inner side of the lipid bilayer in virion, where it binds the RNP. During virus entry into cell, the M2 ion channel acidifies the internal virion core, inducing M1 dissociation from the RNP. M1-free RNPs are transported to the nucleus, where viral transcription and replication can take place By similarity. Spearmint SPM013188

Ontologies

Keywords
Cellular component	Membrane Spearmint SPM013188 Nucleus Spearmint SPM013188 Viral matrix protein Spearmint SPM013188 Virion
Ligand	RNA-binding Spearmint SPM013188
Gene Ontology (GO)
Cellular component	membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-KW virion Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0A1C9-1 [UniParc]. Last modified February 20, 2007. Version 2. Checksum: 20BD8D105A13BB4E	FASTA	252	27,854
	10 20 30 40 50 60 MSLLTEVETY VLSIVPSGPL KAEIAQRLED VFAGKNTDLE ALMEWLKTRP ILSPLTKGIL 70 80 90 100 110 120 GFVFTLTVPS ERGLQRRRFV QNALNGNGDP NNMDRAVKLY RKLKREITFH GAKEVALSYS 130 140 150 160 170 180 TGALASCMGL IYNKMGTVTT EVAFGLVCAT CEQIADSQHR SHRQMATTTN PLIRHENRMV 190 200 210 220 230 240 LASTTAKAME QMAGSSEQAA EAMEVASQAR QMVQAMRTIG THPSSSAGLK DDLLENLQAY 250 QKRMGVQMQR FK

References

[1]

"Pneumo- and neurotropism of avian origin Italian highly pathogenic avian influenza H7N1 isolates in experimentally infected mice." Rigoni M., Shinya K., Toffan A., Milani A., Bettini F., Kawaoka Y., Cattoli G., Capua I. Virology 364:28-35(2007) [PubMed: 17408714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: A/ostrich/Italy/984/00 EMBL ABJ90272.2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ991338 Viral cRNA. Translation: ABJ90272.2. DQ991346 Viral cRNA. Translation: ABJ90283.2.
3D structure databases
SMR	A0A1C9. Positions 1-158.
ModBase	Search...
Family and domain databases
InterPro	IPR013188. Flu_matrix_M1_C. IPR001561. Flu_matrix_M1_N. IPR015799. Flu_matrix_M1_N_sub2. [Graphical view]
Gene3D	G3DSA:1.10.10.180. Flu_matrix_M1_N_sub2. 1 hit.
Pfam	PF00598. Flu_M1. 1 hit. PF08289. Flu_M1_C. 1 hit. [Graphical view]
ProDom	PD001061. Flu_M1. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00759. Flu_M1_C. 1 hit. [Graphical view]

Entry information

Entry name

A0A1C9_9INFA

Accession

Primary (citable) accession number: A0A1C9
Secondary accession number(s): A0A1E1

Entry history

Integrated into UniProtKB/TrEMBL:	November 14, 2006
Last sequence update:	February 20, 2007
Last modified:	September 2, 2008
This is version 16 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)