Unreviewed, UniProtKB/TrEMBL A0A4M5 (A0A4M5_9INFA)

Names and origin

Protein names

Submitted name:
    Neuraminidase RuleBase RU003708V0
    EC=3.2.1.18

Gene names

Name:

NA EMBL ABJ90250.2

Organism

Influenza A virus (A/chicken/Italy/5093/99(H7N1)) EMBL ABJ90250.2

Taxonomic identifier

414453 [NCBI]

Taxonomic lineage

Viruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A

Protein attributes

Sequence length	447 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells By similarity. RuleBase RU003708V0
Catalytic activity	Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. RuleBase RU003708V0 Spearmint SPM001860
Subunit structure	Homotetramer By similarity. Spearmint SPM001860 RuleBase RU003708V0
Subcellular location	Virion membrane. Apical cell membrane; Single-pass type II membrane proteinBy similarity. RuleBase RU003708V0
Sequence similarities	Belongs to the glycosyl hydrolase 34 family. RuleBase RU003708V0

Ontologies

Keywords
Cellular component	Membrane Virion Spearmint SPM001860
Domain	Transmembrane Spearmint SPM001860 RuleBase RU003708V0
Molecular function	Glycosidase Spearmint SPM001860 RuleBase RU003708V0 Hydrolase
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	apical plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW virion membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	exo-alpha-sialidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0A4M5-1 [UniParc]. Last modified February 20, 2007. Version 2. Checksum: ECD54B717A9D9508	FASTA	447	48,916
	10 20 30 40 50 60 MNPNQKIITI GSICMVIGIV SLMLQIGNII SIWVSHSIQT GNQYQPEPCN QSITEQAVTS 70 80 90 100 110 120 VTLAGNSSLC PISGWAIYSK DNGIRIGSKG DVFVIREPFI SCSHLECRTF FLTQGALLND 130 140 150 160 170 180 KHSNGTVKDR SPYRTLMSCP VGEAPSPYNS KFESVAWSAS ACHDGISWLT IGISGPDNGA 190 200 210 220 230 240 VAVLKYNGII TDTIKSWRNN ILRTQESECA CVNGSCFTVM TDGPSNGQAS YKIFKIEKGK 250 260 270 280 290 300 VVKSVELNAP NYHYEECSCY PDAGEIMCVC RDNWHGSNRP WVSFNQNLEY QIGYICSGVF 310 320 330 340 350 360 GDNPRPNDGT GSCGPMSSNG AYGVKGFSFK YGNGVWIGRT KSTSSRSGFE MIWDPNGWTE 370 380 390 400 410 420 TDSSFSVKQD IVAITDWSGY SGSFVQHPEL TGLDCMRPCF WVELIRGRPK ENTIWTSGSS 430 440 ISFCGVNSDT VGWSWPDGAE LPFTIDK

References

[1]

"Pneumo- and neurotropism of avian origin Italian highly pathogenic avian influenza H7N1 isolates in experimentally infected mice." Rigoni M., Shinya K., Toffan A., Milani A., Bettini F., Kawaoka Y., Cattoli G., Capua I. Virology 364:28-35(2007) [PubMed: 17408714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: A/chicken/Italy/5093/99 EMBL ABJ90250.2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ991322 Viral cRNA. Translation: ABJ90250.2. DQ991330 Viral cRNA. Translation: ABJ90261.2.
3D structure databases
SMR	A0A4M5. Positions 61-445.
ModBase	Search...
Family and domain databases
InterPro	IPR001860. Glyco_hydro_34. [Graphical view]
Pfam	PF00064. Neur. 1 hit. [Graphical view]
ProDom	PD000431. Glyco_hydro_34. 1 hit. [Graphical view] [Entries sharing at least one domain]

Entry information

Entry name

A0A4M5_9INFA

Accession

Primary (citable) accession number: A0A4M5
Secondary accession number(s): A0A4N6

Entry history

Integrated into UniProtKB/TrEMBL:	November 14, 2006
Last sequence update:	February 20, 2007
Last modified:	July 22, 2008
This is version 15 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)