Unreviewed, UniProtKB/TrEMBL A0A4M8 (A0A4M8_9INFA)

Names and origin

Protein names

Submitted name:
    Nonstructural protein 2 EMBL ABJ90254.2

Gene names

Name:

NS2 EMBL ABJ90254.2

Organism

Influenza A virus (A/chicken/Italy/5093/99(H7N1)) EMBL ABJ90254.2

Taxonomic identifier

414453 [NCBI]

Taxonomic lineage

Viruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A

Protein attributes

Sequence length	121 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

General annotation (Comments)

Function	Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs to which the M1 protein is bound. Because the M1 protein is not available in large quantities until the later stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the nucleus before sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enters the cytoplasm only when they have associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced. Spearmint SPM000256
Subunit structure	Binds M1 protein. May interact with human nucleoporin RAB/HRB and exportin XPO1/CRM1. Spearmint SPM000256
Subcellular location	VirionPotential. Nucleus. Spearmint SPM000256

Ontologies

Keywords
Biological process	Host-virus interaction Spearmint SPM000256 Transport Spearmint SPM000256
Cellular component	Nucleus Spearmint SPM000256 Virion Spearmint SPM000256
Gene Ontology (GO)
Biological process	interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW virion Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0A4M8-1 [UniParc]. Last modified February 20, 2007. Version 2. Checksum: 71153F50CA9A3E32	FASTA	121	14,273
	10 20 30 40 50 60 MDSNTITSFQ DILQRMSKMQ LESSSVDLNG MITQFERLKI YRDSLGESVM RMGDLHSLQS 70 80 90 100 110 120 RNATWRDELS QKFEEIRWLI AECRNILTKT ENSFEQITFL QALQLLLEVE SEIRTFSFQL I

References

[1]

"Pneumo- and neurotropism of avian origin Italian highly pathogenic avian influenza H7N1 isolates in experimentally infected mice." Rigoni M., Shinya K., Toffan A., Milani A., Bettini F., Kawaoka Y., Cattoli G., Capua I. Virology 364:28-35(2007) [PubMed: 17408714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: A/chicken/Italy/5093/99 EMBL ABJ90254.2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ991324 Viral cRNA. Translation: ABJ90254.2. DQ991332 Viral cRNA. Translation: ABJ90265.2.
3D structure databases
SMR	A0A4M8. Positions 65-116.
ModBase	Search...
Family and domain databases
InterPro	IPR000256. Flu_NS1. IPR000968. Flu_NS2. [Graphical view]
Pfam	PF00600. Flu_NS1. 1 hit. PF00601. Flu_NS2. 1 hit. [Graphical view]

Entry information

Entry name

A0A4M8_9INFA

Accession

Primary (citable) accession number: A0A4M8
Secondary accession number(s): A0A4N9

Entry history

Integrated into UniProtKB/TrEMBL:	November 14, 2006
Last sequence update:	February 20, 2007
Last modified:	September 23, 2008
This is version 20 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)