Reviewed, UniProtKB/Swiss-Prot A2RSX7 (CB060_MOUSE)

Names and origin

Protein names	Recommended name:     JmjC domain-containing protein C2orf60 homolog
Organism	Mus musculus (Mouse)
Taxonomic identifier	10090 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities	Contains 1 JmjC domain.
Sequence caution	The sequence AAH99495.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A2RSX7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A2RSX7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     72-121: SKNFVYRTLP...EDPRKDVADI → KLYLLTSWSR...LQTSDSSSHH
     122-315: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 315	315	JmjC domain-containing protein C2orf60 homolog
Regions
	Domain	102 – 267	166	JmjC
Natural variations
	Alternative sequence	72 – 121	50	SKNFV…DVADI → KLYLLTSWSREQPKKHIKNS SFQRMRNTTYGHLEKTQGRM LQTSDSSSHH in isoform 2.
	Alternative sequence	122 – 315	194	Missing in isoform 2.
Experimental info
	Sequence conflict	5	1	R → H in AAI32290. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 13, 2007. Version 2. Checksum: 26B51EF4662C55A3	FASTA	315	36,633
	10 20 30 40 50 60 MAEQRLPVPR LRGVSREQFM EHLYPQRKPL VLEGLDLGSC TSKWTVDYLS QVGGTKEVKI 70 80 90 100 110 120 HVAAVPQMDF ISKNFVYRTL PFNKLVQRAA EETHKEFFIS EDEKYYLRSL GEDPRKDVAD 130 140 150 160 170 180 IRQQFPSLGG DITFPMFFRE EQFFSSVFRI SSPGLQLWTH YDVMDNFLIQ VTGKKRITLF 190 200 210 220 230 240 NPRDAQYLYL SGSKSEVLNI DSPDLDKYPL FPKARRYECS LEAGDVLFIP ALWFHNVVSE 250 260 270 280 290 300 EFGVGVNIFW KHLPSECYDT TDTYGNKDPV AASRAVQILD RALKTLAELP EEYRDFYARQ 310 MVLRIQDKAY SKNFE
	Isoform 2 [UniParc]. Checksum: 313F14E41B27AA96		121	14,024
	10 20 30 40 50 60 MAEQRLPVPR LRGVSREQFM EHLYPQRKPL VLEGLDLGSC TSKWTVDYLS QVGGTKEVKI 70 80 90 100 110 120 HVAAVPQMDF IKLYLLTSWS REQPKKHIKN SSFQRMRNTT YGHLEKTQGR MLQTSDSSSH H

References

[1]

"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6J. Tissue: Egg.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-315 (ISOFORM 2). Tissue: Brain and Thyroid.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK139666 mRNA. Translation: BAE24098.1. BC099495 mRNA. Translation: AAH99495.1. Sequence problems. BC132289 mRNA. Translation: AAI32290.1.
RefSeq	NP_001032831.2. NP_001107574.1.
UniGene	Mm.288490
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000048495. Mus musculus. [Contig view]
GeneID	68736.
KEGG	mmu:68736.
Organism-specific databases
MGI	MGI:1915986. 1110034B05Rik.
Phylogenomic databases
HOVERGEN	A2RSX7.
Gene expression databases
CleanEx	MM_1110034B05RIK.
Family and domain databases
InterPro	IPR003347. TF_JmjC_AAH. [Graphical view]
SMART	SM00558. JmjC. 1 hit. [Graphical view]
PROSITE	PS51184. JMJC. 1 hit. [Graphical view]
ProDom	A2RSX7. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

CB060_MOUSE

Accession

Primary (citable) accession number: A2RSX7
Secondary accession number(s): Q3UT82, Q4KL17

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	November 13, 2007
Last modified:	September 2, 2008
This is version 9 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)