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Reviewed, UniProtKB/Swiss-Prot Q6S5H5 (A26C2_HUMAN)

Last modified September 2, 2008. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    ANKRD26-like family C member 2
Alternative name(s):
    Prostate, ovary, testis-expressed protein on chromosome 14
      Short name=POTE-14
Gene names
Name: A26C2
Synonyms: POTE14
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length594 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Sequence similarities

Belongs to the POTE family.

Contains 5 ANK repeats.

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Ontologies

Keywords

   Coding sequence diversityAlternative splicing
   DomainANK repeat
Repeat

Gene Ontology (GO)

None. [Check GOA]

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6S5H5-1)

Also known as: POTE14B;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6S5H5-2)

Also known as: POTE14C;

The sequence of this isoform differs from the canonical sequence as follows:
     271-356: Missing.
     556-594: SDEQNDTQKQLSEEQNTGILQDEILIHEEKQIEVAENEF → RDFSGHPNFPTTLPIKQ
Isoform 3 (identifier: Q6S5H5-3)

Also known as: POTE14A;

The sequence of this isoform differs from the canonical sequence as follows:
     271-356: Missing.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 594594ANKRD26-like family C member 2

Regions

Repeat172 – 20130ANK 1
Repeat205 – 23430ANK 2
Repeat238 – 26730ANK 3
Repeat357 – 38630ANK 4
Repeat390 – 41930ANK 5
Compositional bias307 – 33226Phe-rich

Natural variations

Alternative sequence271 – 35686Missing in isoform 2 and isoform 3.
Alternative sequence556 – 59439SDEQN…AENEF → RDFSGHPNFPTTLPIKQ in isoform 2.

Experimental info

Sequence conflict331P → A in AAS58870. Ref.1
Sequence conflict661R → C in AAS58870. Ref.1
Sequence conflict761S → G in AAS58870 and AAS58871. Ref.1
Sequence conflict2011I → V in AAS58870. Ref.1
Sequence conflict2171Q → R in AAS58868. Ref.1
Sequence conflict2171Q → R Ref.2
Sequence conflict2421A → T in AAS58871. Ref.1
Sequence conflict4351H → R in AAS58870 and AAS58871. Ref.1
Sequence conflict4511M → I in AAS58868. Ref.1
Sequence conflict4651L → S in AAS58870. Ref.1
Sequence conflict4651L → S in AAI27624. Ref.3
Sequence conflict5201T → P in AAS58868. Ref.1
Sequence conflict5201T → P Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (POTE14B) [UniParc].

Last modified July 22, 2008. Version 3.
Checksum: 4E2C8B857CB7FCEA

FASTA59467,077
        10         20         30         40         50         60 
MVAEAGSMPA ASSVKKPFGL RSKMGKWCRH CFPWCRGSGK SNVGTSGDHD DSAMKTLRSK 

        70         80         90        100        110        120 
MGKWCRHCFP WCRGSSKSNV GTSGDHDDSA MKTLRSKMGK WCCHCFPCCR GSGKSKVGPW 

       130        140        150        160        170        180 
GDYDDSAFME PRYHVRREDL DKLHRAAWWG KVPRKDLIVM LKDTDMNKKD KQKRTALHLA 

       190        200        210        220        230        240 
SANGNSEVVK LLLDRRCQLN ILDNKKRTAL TKAVQCQEDE CALMLLEHGT DPNIPDEYGN 

       250        260        270        280        290        300 
TALHYAIYNE DKLMAKALLL YGADIESKNK IESHSVSQAG VQWCDHSSLQ PRPPEAQMVL 

       310        320        330        340        350        360 
QPQPQLFFFL SFFLFLFLFL FFFSRDEVFA MFLRLVLNSW AQAIHPPQPP KVLGLQHGLT 

       370        380        390        400        410        420 
PLLLGVHEQK QQVVKFLIKK KANLNALDRY GRTALILAVC CGSASIVSLL LEQNIDVSSQ 

       430        440        450        460        470        480 
DLSGQTAREY AVSSHHNVIC QLLSDYKEKQ MLKVSSENSN PEQDLKLTSE EESQRLKGSE 

       490        500        510        520        530        540 
NSQPEEMSQE PEINKGGDRK VEEEMKKHGS THMGFPENLT NGATADNGDD GLIPPRKSRT 

       550        560        570        580        590 
PESQQFPDTE NEQYHSDEQN DTQKQLSEEQ NTGILQDEIL IHEEKQIEVA ENEF

« Hide

Isoform 2 (POTE14C) [UniParc].

Checksum: 0415E0FCA9604CE7
Show »

48654,455
Isoform 3 (POTE14A) [UniParc].

Checksum: DF9A9D8622DF1626
Show »

50857,072

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References

« Hide 'large scale' references
[1]"Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths."
Bera T.K., Huynh N., Maeda H., Sathyanarayana B.K., Lee B., Pastan I.
Gene 337:45-53(2004) [PubMed: 15276201] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Prostate.
[2]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed: 12508121] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-458 (ISOFORM 3).

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Cross-references

Sequence databases

AY462874 mRNA. Translation: AAS58868.1.
AY465171 mRNA. Translation: AAS58870.1.
AY465172 mRNA. Translation: AAS58871.1.
AL512624 Genomic DNA. No translation available.
BC127623 mRNA. Translation: AAI27624.1.
RefSeqNP_001005356.1.
UniGeneHs.581075
Hs.684914

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteQ6S5H5.

Genome annotation databases

EnsemblENSG00000198062. Homo sapiens. [Contig view]
GeneID404785.
KEGGhsa:404785.

Organism-specific databases

H-InvDBHIX0024305.
HGNCHGNC:33896. A26C2.
MIM608916. gene.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ6S5H5.
HOVERGENQ6S5H5.

Gene expression databases

CleanExHS_A26C2.

Family and domain databases

InterProIPR002110. ANK.
[Graphical view]
Gene3DG3DSA:1.25.40.20. ANK. 1 hit.
PfamPF00023. Ank. 6 hits.
[Graphical view]
PRINTSPR01415. ANKYRIN.
SMARTSM00248. ANK. 6 hits.
[Graphical view]
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProDomQ6S5H5.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

SOURCESearch...
ProtoNetSearch...

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Entry information

Entry nameA26C2_HUMAN
AccessionPrimary (citable) accession number: Q6S5H5
Secondary accession number(s): A1L153 expand/collapse secondary AC list , A6NMI9, Q6S5H6, Q6S8J2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 22, 2008
Last modified: September 2, 2008
This is version 39 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents