Reviewed, UniProtKB/Swiss-Prot Q9BMX0 (ERF1_DICDI)

Names and origin

Protein names

Recommended name:
    Eukaryotic peptide chain release factor subunit 1
      Short name(s)=Eukaryotic release factor 1, eRF1

Gene names

Name:	erf1
ORF Names:	DDB_0191343

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA By similarity.
Subunit structure	Heterodimer of two subunits, one of which binds GTP By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the eukaryotic release factor 1 family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 441	441	Eukaryotic peptide chain release factor subunit 1
Experimental info
	Sequence conflict	334	1	L → F in AAK07832. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9BMX0-1 [UniParc]. Last modified December 4, 2007. Version 2. Checksum: A790AA1F6D2AF974	FASTA	441	49,346
	10 20 30 40 50 60 MSAVDDQQNA DKQVEQWKIK KLIKNLEAAR GNGTSMISLI IRPGDQIAKV NKMLAEEYGT 70 80 90 100 110 120 ASNIKSRVNR LSVLGAITSA QQRLKLYTKV PDNGLVIYCG TMVTDEGKEK PVRIDIEPFK 130 140 150 160 170 180 PINTSLYLCD NKFHTAPLGE LLESDEKFGF IVVDGNGALF GLLCGSTRTV LHKITVDLPK 190 200 210 220 230 240 KHGRGGQSAL RFARLRMEKR HNYVRKVSEL ATQFYVTNDK PNVSGLILAG SADFKTELGT 250 260 270 280 290 300 SDMFDQRLRE KIIKIVDVSY GGDNGFNQAI ELSGEVLSSV KFIQEKKLIS QFFEEIAQDT 310 320 330 340 350 360 GKYCFGIADT LKALDLGAAH TLIVWESLET IRYLLRLPTG EEKVIFLNKD QNKDASVFKD 370 380 390 400 410 420 KESGLDYEIV EEMPIVEWFA NNYKNFGASL EFVTNKSQEG SQFCKGFGGL GGLLRYQVDF 430 440 AQLNDFDNPD ENEYDDSDSD F

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Class I release factors in ciliates with variant genetic codes." Inagaki Y., Doolittle W.F. Nucleic Acids Res. 29:921-927(2001) [PubMed: 11160924] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF298834 mRNA. Translation: AAK07832.1. AAFI02000119 Genomic DNA. Translation: EAL63131.1.
RefSeq	XP_636638.1.
3D structure databases
HSSP	HSSP built from PDB template 1DT9 based on UniProtKB P46055.
ModBase	Search...
Genome annotation databases
GeneID	3388208.
KEGG	ddi:DDB_0191343.
Organism-specific databases
dictyBase	DDB0191343. erf1.
Family and domain databases
InterPro	IPR004403. eRF1. IPR005140. eRF1_1. IPR005141. eRF1_2. IPR005142. eRF1_3. [Graphical view]
PANTHER	PTHR10113. eRF1. 1 hit.
Pfam	PF03463. eRF1_1. 1 hit. PF03464. eRF1_2. 1 hit. PF03465. eRF1_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR00108. eRF. 1 hit.
ProDom	Q9BMX0. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ERF1_DICDI

Accession

Primary (citable) accession number: Q9BMX0
Secondary accession number(s): Q54IP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
Last sequence update:	December 4, 2007
Last modified:	July 22, 2008
This is version 36 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)