Reviewed, UniProtKB/Swiss-Prot Q5V9E9 (G6PI_DICDI)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate isomerase
      Short name(s)=GPI
    EC=5.3.1.9
Alternative name(s):
    Phosphoglucose isomerase
      Short name(s)=PGI
    Phosphohexose isomerase
      Short name(s)=PHI

Gene names

Name:	gpi
Synonyms:	g6pi, pgi
ORF Names:	DDB_0231026

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	561 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate.
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 561	561	Glucose-6-phosphate isomerase
Sites
	Active site	397	1	By similarity
	Active site	525	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5V9E9-1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: B49E0503E55D7F77	FASTA	561	63,465
	10 20 30 40 50 60 MEEFKNLKEH YENIGKNINM RKEFESNYGA TRFKDFSKEV NISKQVGTIL LDYSKNRINK 70 80 90 100 110 120 ETMDLLFELA RASKVEEMRN SMFQGEKINI TEDRAVLHTA LRNRDPSAVI KVDGENVIPS 130 140 150 160 170 180 VRKVLDKMRS FSERVRSGQW KGYTGKTITD VVNIGIGGSD LGPVMVTQAL KNYANDKVMR 190 200 210 220 230 240 AHFVSNIDGT HLAETVKHLC PETTLFIVAS KTFTTQETIT NAQSARSWFL EKIGGSSVSA 250 260 270 280 290 300 DVQKHAIGQH FVALSTNEQE VTKFGILKEN MFEFWDWVGG RYSVWSAIGL SVALYVGMDH 310 320 330 340 350 360 FESFLEGAYH MDQHFLNTPL ELNLPVIMGL LGVWYNNFFG CQTQAILPYD QYLSRFPAYF 370 380 390 400 410 420 QQGDMESNGK SVQRNGERVT HSTGPIIWGE PGTNGQHAFY QLIHQGQKII PCDFIASVES 430 440 450 460 470 480 HNPLGKHHQI LLSNFFAQTE ALMKGKNEQE VTNELTKEGL SQEKIKQLLP HKVFEGNRPT 490 500 510 520 530 540 NSIFLHKLTP HSLGALIALY EHKIFVQGII WNINSFDQWG VELGKQLAKS ILPELSDNNE 550 560 VSTHDSSTNG LINFYKSNSK L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cryptosporidium parvum: phylogenomic evidence for organelle loss, intracellular and horizontal gene transfer." Huang J., Mullapudi N., Lancto C., Scott M., Abrahamsen M., Kissinger J.C. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY581146 Genomic DNA. Translation: AAT92030.1. AAFI02000056 Genomic DNA. Translation: EAL65603.1.
RefSeq	XP_638957.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3390546.
KEGG	ddi:DDB_0231026.
Organism-specific databases
dictyBase	DDB0231026. gpi.
Family and domain databases
InterPro	IPR001672. G6P_Isomerase. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. [Graphical view]
ProDom	Q5V9E9. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

G6PI_DICDI

Accession

Primary (citable) accession number: Q5V9E9
Secondary accession number(s): Q54QR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 7, 2004
Last modified:	July 22, 2008
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)