Reviewed, UniProtKB/Swiss-Prot Q76NW2 (H4_DICDI)

Names and origin

Protein names

Recommended name:
    Histone H4

Gene names

Name:	H4a
ORF Names:	DDB_0216310
AND
Name:	H4b
ORF Names:	DDB_0216311

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	108 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subunit structure	The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the histone H4 family.

Ontologies

Keywords
Cellular component	Chromosomal protein Nucleosome core Nucleus
Ligand	DNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 108	108	Histone H4

Sequences

	Sequence		Length	Mass (Da)
	Q76NW2-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: A701702655B3D708	FASTA	108	12,017
	10 20 30 40 50 60 MSSAQSRGGK TGGKVGGKVG AKRHKKTQKE HINGITKPAI RRLARRGGVK RISFPIYEET 70 80 90 100 RNVLRTFLTN VIRDSVAYTE HAGRRTVTAM DVVYALKRQG RTLYGFNS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[3]	"Purification and the histones of Dictyostelium discoideum chromatin." Bakke A.C., Bonner J. Biochemistry 18:4556-4562(1979) [PubMed: 497154] [Abstract] Cited for: PURIFICATION, AMINO-ACID COMPOSITION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC117075 Genomic DNA. Translation: AAO50807.1. AC116977 Genomic DNA. Translation: AAO51205.1. AAFI02000019 Genomic DNA. Translation: EAL68777.1. AAFI02000019 Genomic DNA. Translation: EAL68933.1.
RefSeq	XP_642712.1. XP_642958.1.
3D structure databases
SMR	Q76NW2. Positions 17-106.
ModBase	Search...
Genome annotation databases
GeneID	3393844. 3394088.
KEGG	ddi:DDB_0216310. ddi:DDB_0216311.
Organism-specific databases
dictyBase	DDB0216310. H4a. DDB0216311. H4b.
Family and domain databases
InterPro	IPR009072. Histone-fold. IPR007125. Histone_core_D. IPR001951. Histone_H4. [Graphical view]
Gene3D	G3DSA:1.10.20.10. Histone-fold. 1 hit.
PANTHER	PTHR10484. Histone_H4. 1 hit.
Pfam	PF00125. Histone. 1 hit. [Graphical view]
PRINTS	PR00623. HISTONEH4.
ProDom	PD001827. Histone_H4. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00417. H4. 1 hit. [Graphical view]
PROSITE	PS00047. HISTONE_H4. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

H4_DICDI

Accession

Primary (citable) accession number: Q76NW2
Secondary accession number(s): Q550A4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 5, 2004
Last modified:	July 22, 2008
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)