Reviewed, UniProtKB/Swiss-Prot P54651 (HSC90_DICDI)

Names and origin

Protein names

Recommended name:
    Heat shock cognate 90 kDa protein

Gene names

Name:	hspD
Synonyms:	hsc90, hsp90
ORF Names:	DDB_0191163

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	700 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Molecular chaperone. Has ATPase activity By similarity.
Subcellular location	CytoplasmPotential.
Sequence similarities	Belongs to the heat shock protein 90 family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 700	700	Heat shock cognate 90 kDa protein
Sites
	Binding site	40	1	ATP By similarity
	Binding site	82	1	ATP By similarity
	Binding site	95	1	ATP By similarity
	Binding site	128	1	ATP; via amide nitrogen By similarity
Experimental info
	Sequence conflict	670	1	A → S in AAA69917. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P54651-1 [UniParc]. Last modified December 4, 2007. Version 2. Checksum: 91D5ECF238088FF2	FASTA	700	79,866
	10 20 30 40 50 60 MAESQVERFT FQAEINQLMS LIINTFYSNK EVFLRELISN ASDALDKIRY QSLTDASVLE 70 80 90 100 110 120 SKTELEIKII PDKTAKTLTL IDSGIGMTKT DMVKNLGTIA RSGTKNFMEQ LQSGAADISM 130 140 150 160 170 180 IGQFGVGFYS AYLVADTVIV HSKNNDDEQY VWESSAGGEF TIALDHTEPL GRGTKIVLHM 190 200 210 220 230 240 KEDQLDYLDE TKIKNLVKKH SEFIQYPISL LTIKEKEVDE ETTAKEGEEE STDAKIEEIE 250 260 270 280 290 300 EEKEKKKVKV QEKEWDVLNK TKPLWTRNPS DVTKEEYNSF YKSISNDWEE PLAVKHFSVE 310 320 330 340 350 360 GQLEFKAILF VPKKAPFDLF ESKKKANNIK LYVKRVFIMD NCADIIPEYL NFVRGIVDSE 370 380 390 400 410 420 DLPLNISRET LQQNKILTVI RKNLVKKCIE LFNEIAENSE DYKKFYEAFS KNLKLGVHED 430 440 450 460 470 480 SQNREKFADL LRYQTSKSGD ELVTLKEYVG RMKEGQNEIY YITGESKKAV ENSPFIEGLK 490 500 510 520 530 540 KKNLEVIYMC DPIDEYAVQQ LKEYDGKKLV SITKEGLKLD ETEDEKKKAE QDKAANEELL 550 560 570 580 590 600 KQVKDVLGDK VEKVVLSTRL ANSPCVLVTS EYGWSANMER IMKAQALRDS SMSSYMSSKK 610 620 630 640 650 660 TLELNPDHPI VRDLAKKAAE KSKTFKDFVY LLYETALLTS GFSLDEPSSF ASRIHRMIKL 670 680 690 700 GLSIQDDSSA TTEESTNTTT SDDIPPLEEN DEPSEMEKVD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Boves H., Dittrich W., Mintert U., Lottspeich F., Gerisch G., Faix J. Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: AX3.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[3]	"Identification of novel centrosomal proteins in Dictyostelium discoideum by comparative proteomic approaches." Reinders Y., Schulz I., Graef R., Sickmann A. J. Proteome Res. 5:589-598(2006) [PubMed: 16512674] [Abstract] Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[4]	"Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake." Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M., Soldati T. Mol. Cell. Proteomics 5:2228-2243(2006) [PubMed: 16926386] [Abstract] Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L43591 mRNA. Translation: AAA69917.1. AAFI02000003 Genomic DNA. Translation: EAL73152.1.
RefSeq	XP_647482.1.
3D structure databases
HSSP	HSSP built from PDB template 1YER based on UniProtKB P07900.
ModBase	Search...
Genome annotation databases
GeneID	3398236.
KEGG	ddi:DDB_0191163.
Organism-specific databases
dictyBase	DDB0191163. hspD.
Family and domain databases
InterPro	IPR003594. ATP_bd_ATPase. IPR001404. Hsp90. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit.
PANTHER	PTHR11528. Hsp90. 1 hit.
Pfam	PF02518. HATPase_c. 1 hit. PF00183. HSP90. 1 hit. [Graphical view]
PIRSF	PIRSF002583. Hsp90. 1 hit.
PRINTS	PR00775. HEATSHOCK90.
SMART	SM00387. HATPase_c. 1 hit. [Graphical view]
PROSITE	PS00298. HSP90. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

HSC90_DICDI

Accession

Primary (citable) accession number: P54651
Secondary accession number(s): Q55FQ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	December 4, 2007
Last modified:	September 23, 2008
This is version 46 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)