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Reviewed, UniProtKB/Swiss-Prot O02667 (AA3R_RABIT)

Last modified September 2, 2008. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Adenosine A3 receptor
Gene names
Name: ADORA3
OrganismOryctolagus cuniculus (Rabbit)
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

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Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Post-translational modification

Phosphorylation on Ser-318 may be crucial for rapid desensitization By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Ontologies

Keywords

   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
Lipoprotein
Palmitate
Phosphoprotein

Gene Ontology (GO)

None. [Check GOA]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 319319Adenosine A3 receptor

Regions

Topological domain1 – 1515Extracellular Potential
Transmembrane16 – 38231 Potential
Topological domain39 – 4911Cytoplasmic Potential
Transmembrane50 – 73242 Potential
Topological domain74 – 8512Extracellular Potential
Transmembrane86 – 107223 Potential
Topological domain108 – 12720Cytoplasmic Potential
Transmembrane128 – 149224 Potential
Topological domain150 – 17829Extracellular Potential
Transmembrane179 – 199215 Potential
Topological domain200 – 23233Cytoplasmic Potential
Transmembrane233 – 256246 Potential
Topological domain257 – 2626Extracellular Potential
Transmembrane263 – 285237 Potential
Topological domain286 – 31934Cytoplasmic Potential

Amino acid modifications

Modified residue3181Phosphoserine By similarity
Lipidation3041S-palmitoyl cysteine Potential
Glycosylation41N-linked (GlcNAc...) Potential
Disulfide bond84 ↔ 167 By similarity

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Sequences

Sequence LengthMass (Da)Tools
O02667-1 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: BB82C34B1AF96500

FASTA31936,307
        10         20         30         40         50         60 
MPDNSTTLFL AIRASYIVFE IVIGVCAVVG NVLVIWVIKL NPSLKTTTFY FIFSLALADI 

        70         80         90        100        110        120 
AVGFLVMPLA IVISLGITIG FYSCLVMSCL LLVFTHASIM SLLAIAVDRY LRVKLTVRYR 

       130        140        150        160        170        180 
RVTTQRRIWL ALGLCWVVSL LVGFTPMFGW NMKPTLESAR NYSDFQCKFD SVIPMEYMVF 

       190        200        210        220        230        240 
FSFFTWILIP LLLMCALYVY IFYIIRNKLV QSFSSFKETG AFYRREFKTA KSLFLVLALF 

       250        260        270        280        290        300 
AGCWLPLSII NCVTYFKCKV PDVVLLVGIL LSHANSMMNP IVYACKIQKF KETYLLIFKA 

       310 
RVTCQPSDSL DPSSEQNSE

« Hide

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References

[1]"Cloning, expression and pharmacological characterization of rabbit adenosine A1 and A3 receptors."
Hill R.J., Oleynek J.J., Hoth C.F., Kiron M.A., Weng W., Wester R.T., Tracey W.R., Knight D.R., Buchholz R.A., Kennedy S.P.
J. Pharmacol. Exp. Ther. 280:122-128(1997) [PubMed: 8996189] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.

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Cross-references

Sequence databases

U90718 mRNA. Translation: AAB50560.1.
UniGeneOcu.2128

3D structure databases

HSSPHSSP built from PDB template 1MMH based on UniProtKB P29274.
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Phylogenomic databases

HOVERGENO02667.

Family and domain databases

InterProIPR000466. Adeno_A3_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00555. ADENOSINEA3R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProDomO02667.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameAA3R_RABIT
AccessionPrimary (citable) accession number: O02667
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: September 2, 2008
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents