Reviewed, UniProtKB/Swiss-Prot O06912 (FRDC_HELPY)

Names and origin

Protein names

Recommended name:
    Fumarate reductase cytochrome b subunit

Gene names

Name:	frdC
Ordered Locus Names:	HP_0193

Organism

Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Di-heme cytochrome of the fumarate reductase complex By similarity.
Subunit structure	Part of an enzyme complex containing three subunits: a flavoprotein, an iron-sulfur, and cytochrome b-556 By similarity.
Subcellular location	Cell membrane; Multi-pass membrane proteinBy similarity.

Ontologies

Keywords
Biological process	Electron transport Transport Tricarboxylic acid cycle
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 255	255	Fumarate reductase cytochrome b subunit
Regions
	Transmembrane	33 – 53	21	Potential
	Transmembrane	78 – 98	21	Potential
	Transmembrane	126 – 146	21	Potential
	Transmembrane	168 – 188	21	Potential
	Transmembrane	208 – 228	21	Potential
Sites
	Metal binding	44	1	Iron (heme axial ligand) Potential
	Metal binding	93	1	Iron (heme axial ligand) Potential
	Metal binding	143	1	Iron (heme axial ligand) Potential
	Metal binding	182	1	Iron (heme axial ligand) Potential
Experimental info
	Sequence conflict	86	1	I → V in AAC46063. Ref.1
	Sequence conflict	90	1	L → V in AAC46063. Ref.1
	Sequence conflict	200	1	V → A in AAC46063. Ref.1
	Sequence conflict	236	1	E → D in AAC46063. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O06912-1 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: E74716D64957AD50	FASTA	255	28,886
	10 20 30 40 50 60 MQQEEIIEGY YGASKGLKKS GIYAKLDFLQ SATGLILALF MIAHMFLVSS ILISDEAMYK 70 80 90 100 110 120 VAKFFEGSLF LKAGEPAIVS VVAAGIILIL VAHAFLALRK FPINYRQYKV FKTHKHLMKH 130 140 150 160 170 180 GDTSLWFIQA LTGFAMFFLA SIHLFVMLTE PESIGPHGSS YRFVTQNFWL LYIFLLFAVE 190 200 210 220 230 240 LHGSIGLYRL AIKWGWFKNV SIQGLRKVKW AMSVFFIVLG LCTYGAYIKK GLENKENGIK 250 TMQEAIEADG KFHKE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional characterization of Helicobacter pylori fumarate reductase operon comprising three structural genes coding for subunits C, A and B." Ge Z., Jiang Q., Kalisiak M.S., Taylor D.E. Gene 204:227-234(1997) [PubMed: 9434188] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 43629 / JCM 7656 / NCTC 11639 / UA802.
[2]	"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U78101 Genomic DNA. Translation: AAC46063.1. AE000511 Genomic DNA. Translation: AAD07260.1.
PIR	A64544.
RefSeq	NP_206992.1.
3D structure databases
HSSP	HSSP built from PDB template 1QLA based on UniProtKB P17413.
ModBase	Search...
Genome annotation databases
GeneID	898966.
GenomeReviews	Gene locus HP_0193 in contig AE000511_GR.
KEGG	hpy:HP0193.
NMPDR	fig|85962.1.peg.190.
TIGR	HP_0193.
Phylogenomic databases
HOGENOM	O06912.
Family and domain databases
InterPro	IPR004224. Fum_red_TM. [Graphical view]
Pfam	PF02967. Fum_red_TM. 1 hit. [Graphical view]
PIRSF	PIRSF000177. Fumar_rd_cyt_b. 1 hit.
ProDom	PD020880. Fum_red_TM. 1 hit. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

FRDC_HELPY

Accession

Primary (citable) accession number: O06912

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	September 2, 2008
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)