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Reviewed, UniProtKB/Swiss-Prot O08815 (SLK_RAT)

Last modified December 16, 2008. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    STE20-like serine/threonine-protein kinase
      Short name=STE20-like kinase
    EC=2.7.11.1
Alternative name(s):
    STE20-related serine/threonine-protein kinase
      Short name=STE20-related kinase
Gene names
Name: Slk
Synonyms: Sk2
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length1206 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Mediates apoptosis and actin stress fiber dissolution By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

CytoplasmBy similarity.

Post-translational modification

Proteolytically cleaved by caspase-3 By similarity.

Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

Contains 1 protein kinase domain.

Contains 1 UVR domain.

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself1EBI-986112,EBI-986112
MAP3K5Q996831EBI-986112,EBI-476263From a different organism.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12061206STE20-like serine/threonine-protein kinase
PRO_0000233241

Regions

Domain34 – 292259Protein kinase
Domain874 – 90936UVR
Nucleotide binding40 – 489ATP By similarity
Coiled coil468 – 49225 Potential
Coiled coil825 – 1037213 Potential
Coiled coil1077 – 115175 Potential
Compositional bias16 – 194Poly-Lys
Compositional bias322 – 3254Poly-Asp

Sites

Active site1551Proton acceptor By similarity
Binding site631ATP By similarity
Site438 – 4392Cleavage; by caspase-3 By similarity

Amino acid modifications

Modified residue1891Phosphoserine By similarity
Modified residue3401Phosphoserine By similarity
Modified residue3411Phosphoserine By similarity
Modified residue3441Phosphoserine By similarity
Modified residue3471Phosphoserine By similarity
Modified residue3481Phosphoserine By similarity
Modified residue3541Phosphoserine By similarity
Modified residue5451Phosphoserine By similarity
Modified residue7541Phosphothreonine By similarity
Modified residue7711Phosphoserine By similarity
Modified residue7761Phosphoserine By similarity
Modified residue7781Phosphoserine By similarity
Modified residue8171Phosphoserine By similarity
Modified residue10651Phosphothreonine By similarity

Experimental info

Sequence conflict1651L → I Ref.2

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Sequences

Sequence LengthMass (Da)Tools
O08815-1 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 8F5C6A19A3501FB9

FASTA1,206137,888
        10         20         30         40         50         60 
MSFFNFRKIF KLGSEKKKKQ YEHVKRDLNP EEFWEIIGEL GDGAFGKVYK AQNKETNVLA 

        70         80         90        100        110        120 
AAKVIDTKSE EELEDYMVEI DILASCDHPN IVKLLDAFYY ENNLWILIEF CAGGAVDAVM 

       130        140        150        160        170        180 
LELERPLTES QIQVVCKQTL EALNYLHDNK IIHRDLKAGN ILFTLDGDIK LADFGVSAKN 

       190        200        210        220        230        240 
TRTIQRRDSF IGTPYWMAPE VVMCETSKDR PYDYKADVWS LGITLIEMAE IEPPHHELNP 

       250        260        270        280        290        300 
MRVLLKIAKS EPPTLAQPSR WSSNFKDFLK KCLEKNVDAR WTTSQLLQHP FVTVDSNKPV 

       310        320        330        340        350        360 
RELIAEAKAE VTEEVEDGKE EDDDDETESA LPIPANKRAS SDLSIASSEE DKLSQNACIL 

       370        380        390        400        410        420 
ESVSERTEHN TSGDKFSNKV LSEKPTPEGP EKTVDVDGPA NDVNLETVAE PNDQAVGFHE 

       430        440        450        460        470        480 
NGREKKRPQL ESQPDTEDQQ TVDVNLVGEG NDSNIVILET NTDCLKPEED RNEENQEIIE 

       490        500        510        520        530        540 
NKLTQSEEIK DIHIQTMDLV SQETGEKEAD FQAIDNEVGF TKEETQEKLG KDDKTHKVVI 

       550        560        570        580        590        600 
SDITSEVGTD EPPGDTQKSA EQSQDAEGGA GEEAPEPAQT LTEKATEGPE AHGAEEEPRS 

       610        620        630        640        650        660 
GERVEDKQLE QQSAVCEGEG QVTSTSESTR ATTEEPETDE VDQVSESNSI EELERLGVTG 

       670        680        690        700        710        720 
AEEQALGSKG EAATELDLER EENAQELPVK AEPQAPAASQ ASEPPPVLIP SINIHSENTE 

       730        740        750        760        770        780 
NKGEMGALPK PETILPPEPE NGKGNDTDSG TGSTVENSSS DLNLSISSFL SKTKDSGSVS 

       790        800        810        820        830        840 
LQETRRQKKT LKKTRKFIVD GVEVSVTTSK IVTDSDSKTE ELRFLRRQEL RELRLLQKEE 

       850        860        870        880        890        900 
QKAQQQLNGK LQQQREQIFR RFEQEMLSKK RQYDQEIENL EKQQKQTIER LEQEHTNRLR 

       910        920        930        940        950        960 
DEAKRIKGEQ EKELSKFQNM LRNRKKEEQE FVQKQQQELD GALKKIIQQQ KAELANIERE 

       970        980        990       1000       1010       1020 
CLNNKQQLLR AREAAIWELE ERHLQEKHQL LKQQLKDQYF IQRHQLLKRH EKETEQMQRY 

      1030       1040       1050       1060       1070       1080 
NQRLIEELKN RQTQERARLP KIQRSEAKTR MAMFKKSLRI NSTATPDQDR EKIKQFAAQE 

      1090       1100       1110       1120       1130       1140 
EKRQKNERMA QHQKHESQMR DLQLQCEANV RELHQLQNEK CHLLVEHETQ KLKELDEEHS 

      1150       1160       1170       1180       1190       1200 
QELKEWREKL RPRKKTLEEE FARKLQEQEV FFKMTGESEC LNPSAQSRGC LQTSHPSSTR 


APAWAG

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References

[1]"SK2, a putative rat homologue of yeast protein kinase NRK1."
Fukami Y., Yamamoto H., Ichihara T., Mori K., Gomi T., Sato K.
Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
[2]"Novel putative protein kinase clones from a rat large granular lymphocyte tumor cell line."
Yue C.C.
Mol. Immunol. 28:399-408(1991) [PubMed: 2062320] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 156-214.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AB003357 mRNA. Translation: BAA20077.1.
PIRPT0204.
T34021.
RefSeqNP_062222.2.
UniGeneRn.33275

3D structure databases

HSSPHSSP built from PDB template 1F3M based on UniProtKB Q13153.
SMRO08815. Positions 21-308.
ModBaseSearch...

Protein-protein interaction databases

IntActO08815. 2 interactions.

Genome annotation databases

EnsemblENSRNOG00000011339. Rattus norvegicus. [Contig view]
GeneID54308.
KEGGrno:54308.

Organism-specific databases

RGD3780. Slk.

Phylogenomic databases

HOVERGENO08815.

Gene expression databases

ArrayExpressO08815.
GermOnlineENSRNOG00000011339. Rattus norvegicus.

Family and domain databases

InterProIPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_bd_CS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
IPR002290. Ser_thr_pkinase.
IPR001943. UvrB/C.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
ProDomPD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio610968.

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Entry information

Entry nameSLK_RAT
AccessionPrimary (citable) accession number: O08815
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 1, 1997
Last modified: December 16, 2008
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents