Reviewed, UniProtKB/Swiss-Prot O13076 (AA2BR_CHICK)

Names and origin

Protein names

Recommended name:
    Adenosine receptor A2b
Alternative name(s):
    Adenosine receptor 2b

Gene names

Name:

ADORA2B

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein Lipoprotein Palmitate
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	adenosine receptor activity, G-protein coupled Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	Adenosine receptor A2b		PRO_0000069006
Regions
	Topological domain	1 – 6	6	Extracellular Potential
	Transmembrane	7 – 29	23	1 Potential
	Topological domain	30 – 42	13	Cytoplasmic Potential
	Transmembrane	43 – 65	23	2 Potential
	Topological domain	66 – 76	11	Extracellular Potential
	Transmembrane	77 – 99	23	3 Potential
	Topological domain	100 – 119	20	Cytoplasmic Potential
	Transmembrane	120 – 142	23	4 Potential
	Topological domain	143 – 178	36	Extracellular Potential
	Transmembrane	179 – 203	25	5 Potential
	Topological domain	204 – 235	32	Cytoplasmic Potential
	Transmembrane	236 – 259	24	6 Potential
	Topological domain	260 – 267	8	Extracellular Potential
	Transmembrane	268 – 291	24	7 Potential
	Topological domain	292 – 340	49	Cytoplasmic Potential
Amino acid modifications
	Lipidation	310	1	S-palmitoyl cysteine Potential
	Glycosylation	151	1	N-linked (GlcNAc...) Potential
	Glycosylation	154	1	N-linked (GlcNAc...) Potential
	Disulfide bond	76 ↔ 171		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O13076-1 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 2DAC18E6DC6A950F	FASTA	340	37,772
	10 20 30 40 50 60 MNTMKTTYIV LELIIAVLSI AGNVLVCWAV AINSTLKNAT NYFLVSLAVA DIAVGLLAIP 70 80 90 100 110 120 FAITISIGFQ VDFHSCLFFA CFVLVLTQSS IFSLLAVAID RYLAIKIPLR YNSLVTGKRA 130 140 150 160 170 180 RGLIAVLWLL SFVIGLTPLM GWNKAMSGCP NSTNETGADH GAGHHGCFIS CLFENVVTMS 190 200 210 220 230 240 YMVYFNFFGC VLLPLIIMLG IYIKIFMVAC KQLHQIELMG NSRTTLQKEV HAAKSLAIIV 250 260 270 280 290 300 GLFAFCWLPL HILNCITHFH EEFSKSKPEW VMYVAIILSH ANSVINPIIY AYRIRDFRYT 310 320 330 340 FHKIISKILC KTDDFPKCTT DNNQHLTVTN VNAPAASVTI

References

[1]	"The chicken adenosine receptor 2B gene is regulated by v-myb." Worpenberg S., Burk O., Klempnauer K.H. Oncogene 15:213-221(1997) [PubMed: 9244356] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: SPAFAS.
[2]	"Analysis of DNase I-hypersensitive sites in the chromatin of the chicken adenosine receptor 2B gene reveals multiple cell-type-specific cis-regulatory elements." Braas D., Kattmann D., Miethe J., Klempnauer K.H. Gene 303:157-164(2003) [PubMed: 12559577] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y12601 mRNA. Translation: CAA73173.1. AY169692 Genomic DNA. Translation: AAN87848.1.
RefSeq	NP_990418.1.
UniGene	Gga.43285
3D structure databases
HSSP	HSSP built from PDB template 1MMH based on UniProtKB P29274.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Genome annotation databases
Ensembl	ENSGALG00000014182. Gallus gallus. [Contig view]
GeneID	395971.
KEGG	gga:395971.
Phylogenomic databases
HOVERGEN	O13076.
Family and domain databases
InterPro	IPR001435. Adeno_A2B_rcpt. IPR001634. Adenosn_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00554. ADENOSINA2BR. PR00424. ADENOSINER. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AA2BR_CHICK

Accession

Primary (citable) accession number: O13076
Secondary accession number(s): Q540H7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 1, 1997
Last modified:	November 25, 2008
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)