Reviewed, UniProtKB/Swiss-Prot O13318 (PHR2_CANAL)

Names and origin

Protein names

Recommended name:
    pH-responsive protein 2
Alternative name(s):
    pH-regulated protein 2

Gene names

Name:

PHR2

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	546 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Required for apical cell growth and plays an essential role in morphogenesis. May be integral to the pathogenic ability of the organism By similarity.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchorPotential.
Induction	Repressed at pH values above 6 and progressively induced at more acidic pH values.
Sequence similarities	Belongs to the glycosyl hydrolase 72 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal
PTM	GPI-anchor Glycoprotein Lipoprotein
Gene Ontology (GO)
Cellular component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 517	495	pH-responsive protein 2		PRO_0000010485
	Propeptide	518 – 546	29	Removed in mature form Potential		PRO_0000010486
Regions
	Compositional bias	442 – 523	82	Ser-rich
	Compositional bias	493 – 515	23	Poly-Ser
Amino acid modifications
	Lipidation	517	1	GPI-anchor amidated serine Potential
	Glycosylation	40	1	N-linked (GlcNAc...) Potential
	Glycosylation	59	1	N-linked (GlcNAc...) Potential
	Glycosylation	149	1	N-linked (GlcNAc...) Potential
	Glycosylation	410	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O13318-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 951EE0DB9489CED6	FASTA	546	58,980
	10 20 30 40 50 60 MLLKSLFPSI LAATSFVSSV AAEDLPAIEI VGNKFFYSNN GSQFYIKGIA YQQNNLDSNE 70 80 90 100 110 120 SFVDPLANPE HCKRDIPYLE AVDYDSNVIR VYALDTSQDH TECMQMLQDA GIYVIADLSQ 130 140 150 160 170 180 PDESINRDDP SWDLDLFERY TSVVDLFHNY TNILGFFAGN EVTNKKSNTD ASAFVKAAIR 190 200 210 220 230 240 DTKAYIKSKG YRSIPVGYSA NDDSAIRVSL ADYFACGDED EAADFFGINM YEWCGDSSYK 250 260 270 280 290 300 ASGYESATND YKNLGIPIFF SEYGCNEVRP RKFTEVATLF GDQMTPVWSG GIVYMYFEEE 310 320 330 340 350 360 NNYGLVSIKD NTVSTLKDYS YYSSEIKDIH PSSAKASAES ASSISRTTCP TNTNNWEAST 370 380 390 400 410 420 NLPPTPDKEV CECMSASLKC VVDDKVDSDD YSDLFSYICA KIDCDGINAN GTTGEYGAYS 430 440 450 460 470 480 PCHSKDKLSF VMNLYYEQNK ESKSACDFGG SASLQSAKTA SSCSAYLSSA GSSGLGTVSG 490 500 510 520 530 540 TVRTDTSQST SDSGSGSSSS SSSSSSSSSS GSSGSKSAAS IVSVNLLTKI ATIGISIVVG FGLITM

References

[1]	"PHR2 of Candida albicans encodes a functional homolog of the pH-regulated gene PHR1 with an inverted pattern of pH-dependent expression." Muehlschlegel F.A., Fonzi W.A. Mol. Cell. Biol. 17:5960-5967(1997) [PubMed: 9315654] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF011386 Genomic DNA. Translation: AAB80716.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR004886. GAS1. IPR012946. X8. [Graphical view]
Pfam	PF03198. Glyco_hydro_72. 1 hit. PF07983. X8. 1 hit. [Graphical view]
SMART	SM00768. X8. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PHR2_CANAL

Accession

Primary (citable) accession number: O13318

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	November 4, 2008
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)