Reviewed, UniProtKB/Swiss-Prot O13741 (NOP12_SCHPO)

Names and origin

Protein names

Recommended name:
    Nucleolar protein 12

Gene names

Name:	nop12
ORF Names:	SPAC16E8.06c

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in pre-25S rRNA processing By similarity.
Subcellular location	Nucleus › nucleolusBy similarity.
Sequence similarities	Belongs to the RRM RBM34 family. Contains 2 RRM (RNA recognition motif) domains.

Ontologies

Keywords
Biological process	Ribosome biogenesis rRNA processing
Cellular component	Nucleus
Domain	Repeat
Ligand	RNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	rRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleolus Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 438	438	Nucleolar protein 12		PRO_0000081673
Regions
	Domain	164 – 262	99	RRM 1
	Domain	270 – 348	79	RRM 2
	Compositional bias	20 – 23	4	Poly-Ser
	Compositional bias	81 – 90	10	Poly-Lys
Amino acid modifications
	Modified residue	94	1	Phosphoserine Ref.2
	Modified residue	95	1	Phosphoserine Ref.2

Sequences

	Sequence		Length	Mass (Da)
	O13741-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 3E943401F95E7C12	FASTA	438	49,381
	10 20 30 40 50 60 MGETNSSLDN ENTSFVGKLS SSSNVDPTLN LLFSQSKPIP KPVAKETTVL TKKDVEVEEA 70 80 90 100 110 120 NGVEEAAETI ESDTKEVQNI KPKSKKKKKK LNDSSDDIEG KYFEELLAEE DEEKDKDSAG 130 140 150 160 170 180 LINDEEDKSP AKQSVLEERT SQEDVKSERE VAEKLANELE KSDKTVFVNN LPARVVTNKG 190 200 210 220 230 240 DYKDLTKHFR QFGAVDSIRF RSLAFSEAIP RKVAFFEKKF HSERDTVNAY IVFRDSSSAR 250 260 270 280 290 300 SALSLNGTMF MDRHLRVDSV SHPMPQDTKR CVFVGNLAFE AEEEPLWRYF GDCGSIDYVR 310 320 330 340 350 360 IVRDPKTNLG KGFAYIQFKD TMGVDKALLL NEKKMPEGRT LRIMRAKSTK PKSITRSKRG 370 380 390 400 410 420 DEKTRTLQGR ARKLIGKAGN ALLQQELALE GHRAKPGENP LAKKKVNKKR KERAAQWRNK 430 KAESVGKKQK TAAGKKDK

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

[2]

"Phosphoproteome analysis of fission yeast." Wilson-Grady J.T., Villen J., Gygi S.P. J. Proteome Res. 7:1088-1097(2008) [PubMed: 18257517] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94 AND SER-95, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329670 Genomic DNA. Translation: CAB11047.1.
PIR	T37786.
RefSeq	NP_594218.1.
3D structure databases
HSSP	HSSP built from PDB template 1P1T based on UniProtKB P33240.
ModBase	Search...
Genome annotation databases
GeneID	2542314.
KEGG	spo:SPAC16E8.06c.
NMPDR	fig|4896.1.peg.4188.
Organism-specific databases
GeneDB_Spombe	SPAC16E8.06c.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-001830-MON.
Gene expression databases
ArrayExpress	O13741.
Family and domain databases
InterPro	IPR012677. a_b_plait_nuc_bd. IPR000504. RRM_RNP1. [Graphical view]
Gene3D	G3DSA:3.30.70.330. a_b_plait_nuc_bd. 2 hits.
Pfam	PF00076. RRM_1. 2 hits. [Graphical view]
SMART	SM00360. RRM. 2 hits. [Graphical view]
PROSITE	PS50102. RRM. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NOP12_SCHPO

Accession

Primary (citable) accession number: O13741

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
Last sequence update:	January 1, 1998
Last modified:	November 25, 2008
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)