Reviewed, UniProtKB/Swiss-Prot O14977 (AZIN1_HUMAN)

Names and origin

Protein names

Recommended name:
    Antizyme inhibitor 1
      Short name=AZI
Alternative name(s):
    Ornithine decarboxylase antizyme inhibitor

Gene names

Name:	AZIN1
Synonyms:	OAZI, OAZIN

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Inhibits antizyme-dependent ornithine decarboxylase degradation by binding to antizyme.
Subunit structure	Monomer By similarity.
Tissue specificity	Expressed in liver.
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily.

Ontologies

Keywords
Biological process	Polyamine biosynthesis
Gene Ontology (GO)
Molecular function	enzyme inhibitor activity Ref.1 Traceable author statement. Source: ProtInc protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
OAZ2	O95190	1	EBI-1054824,EBI-1051861

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 448	448	Antizyme inhibitor 1
Experimental info
	Sequence conflict	20	1	N → D in BAA23593. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O14977-1 [UniParc]. Last modified August 15, 2003. Version 2. Checksum: DD26B22A993318E4	FASTA	448	49,535
	10 20 30 40 50 60 MKGFIDDANY SVGLLDEGTN LGNVIDNYVY EHTLTGKNAF FVGDLGKIVK KHSQWQNVVA 70 80 90 100 110 120 QIKPFYTVKC NSAPAVLEIL AALGTGFACS SKNEMALVQE LGVPPENIIY ISPCKQVSQI 130 140 150 160 170 180 KYAAKVGVNI LTCDNEIELK KIARNHPNAK VLLHIATEDN IGGEEGNMKF GTTLKNCRHL 190 200 210 220 230 240 LECAKELDVQ IIGVKFHVSS ACKESQVYVH ALSDARCVFD MAGEIGFTMN MLDIGGGFTG 250 260 270 280 290 300 TEFQLEEVNH VISPLLDIYF PEGSGVKIIS EPGSYYVSSA FTLAVNIIAK KVVENDKFPS 310 320 330 340 350 360 GVEKTGSDEP AFMYYMNDGV YGSFASKLSE DLNTIPEVHK KYKEDEPLFT SSLWGPSCDE 370 380 390 400 410 420 LDQIVESCLL PELNVGDWLI FDNMGADSFH EPSAFNDFQR PAIYYMMSFS DWYEMQDAGI 430 440 TSDSMMKNFF FVPSCIQLSQ EDSFSAEA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor." Koguchi K., Kobayashi S., Hayashi T., Matsufuji S., Murakami Y., Hayashi S. Biochim. Biophys. Acta 1353:209-216(1997) [PubMed: 9349715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed: 16421571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Lung.
[7]	Yu W., Gibbs R.A. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 273-448. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D88674 mRNA. Translation: BAA23593.1. BT006858 mRNA. Translation: AAP35504.1. CR456745 mRNA. Translation: CAG33026.1. AP003354 Genomic DNA. No translation available. CH471060 Genomic DNA. Translation: EAW91851.1. BC013420 mRNA. Translation: AAH13420.1. BC019279 mRNA. Translation: AAH19279.1. AF070634 mRNA. Translation: AAC25391.1.
RefSeq	NP_056962.2. NP_680479.1.
UniGene	Hs.459106
3D structure databases
HSSP	HSSP built from PDB template 7ODC based on UniProtKB P00860.
ModBase	Search...
Protein-protein interaction databases
IntAct	O14977.
Genome annotation databases
Ensembl	ENSG00000155096. Homo sapiens. [Contig view]
GeneID	51582.
KEGG	hsa:51582.
Organism-specific databases
H-InvDB	HIX0007702.
HGNC	HGNC:16432. AZIN1.
MIM	607909. gene.
PharmGKB	PA31887.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	O14977.
Gene expression databases
ArrayExpress	O14977.
CleanEx	HS_AZIN1.
GermOnline	ENSG00000155096. Homo sapiens.
Family and domain databases
InterPro	IPR000183. De-COase2. IPR002433. Orn_de-COase. [Graphical view]
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PRINTS	PR01179. ODADCRBXLASE. PR01182. ORNDCRBXLASE.
PROSITE	PS00878. ODR_DC_2_1. False negative. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProDom	O14977. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

AZIN1_HUMAN

Accession

Primary (citable) accession number: O14977
Secondary accession number(s): A6NCD5, Q6IBQ7, Q96D20

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	August 15, 2003
Last modified:	July 22, 2008
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)