Reviewed, UniProtKB/Swiss-Prot O15021 (MAST4_HUMAN)

Names and origin

Protein names

Recommended name:
    Microtubule-associated serine/threonine-protein kinase 4
    EC=2.7.11.1

Gene names

Name:	MAST4
Synonyms:	KIAA0303

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2444 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Cofactor	Magnesium By similarity.
Subcellular location	CytoplasmPotential.
Tissue specificity	Highly expressed in most normal human tissues, with an exception of in testis, small intestine, colon and peripheral blood leukocyte.
Sequence similarities	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Contains 1 AGC-kinase C-terminal domain. Contains 1 PDZ (DHR) domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O15021-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O15021-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: MKAQRERLQIPGLTLDLTPRSLSPTPSSPGSPCSPLLAFHFW → MDMSDPNFWTVLSNFTLPHLRSGNRLRRTQ
     97-99: Missing.

Notes: No experimental confirmation available.

Isoform 3 (identifier: O15021-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: MKAQRERLQI...SPLLAFHFWS → MDESSILRRR...SQKWNCLVKR
     97-99: Missing.

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 2444	2444	Microtubule-associated serine/threonine-protein kinase 4
Regions
	Domain	391 – 664	274	Protein kinase
	Domain	665 – 737	73	AGC-kinase C-terminal
	Domain	962 – 1050	89	PDZ
	Nucleotide binding	397 – 405	9	ATP By similarity
	Compositional bias	844 – 958	115	Ser-rich
	Compositional bias	1102 – 1164	63	Ser-rich
	Compositional bias	1946 – 2029	84	Pro-rich
Sites
	Active site	514	1	Proton acceptor By similarity
	Binding site	420	1	ATP By similarity
Amino acid modifications
	Modified residue	1240	1	Phosphoserine
	Modified residue	1733	1	Phosphothreonine
	Modified residue	1737	1	Phosphoserine
Natural variations
	Alternative sequence	1 – 43	43	MKAQR…FHFWS → MDESSILRRRGLQKELSLPR RGSLIDSQKWNCLVKR in isoform 3.
	Alternative sequence	1 – 42	42	MKAQR…AFHFW → MDMSDPNFWTVLSNFTLPHL RSGNRLRRTQ in isoform 2.
	Alternative sequence	97 – 99	3	Missing in isoform 2 and isoform 3.
	Natural variant	741	1	Q → R
	Natural variant	1775	1	R → W
	Natural variant	2019	1	P → L
	Natural variant	2111	1	S → C
	Natural variant	2288	1	E → D in a lung squamous cell carcinoma sample; somatic mutation.
Experimental info
	Sequence conflict	171	1	H → R in AAW52510. Ref.1
	Sequence conflict	171	1	H → R in BAB71532. Ref.2
	Sequence conflict	483	1	M → T in BAD18568. Ref.2
	Sequence conflict	495 – 499	5	FAETV → YIVKL in BAB71532. Ref.2
	Sequence conflict	504 – 505	2	YL → FT in BAD18568. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 3, 2006. Version 2. Checksum: FDC6C31BFFCF7C9A	FASTA	2,444	266,113
	10 20 30 40 50 60 MKAQRERLQI PGLTLDLTPR SLSPTPSSPG SPCSPLLAFH FWSCRTSNRK SLIGNGQSPA 70 80 90 100 110 120 LPRPHSPLSA HAGNSPQDSP RNFSPSASAH FSFARRNDRT DGRRWSLASL PSSGYGTNTP 130 140 150 160 170 180 SSTVSSSCSS QEKLHQLPYQ PTPDELHFLS KHFCTTESIA TENRCRNTPM HPRSRSLSPG 190 200 210 220 230 240 RSPACCDHEI IMMNHVYKER FPKATAQMEE RLKEIITSYS PDNVLPLADG VLSFTHHQII 250 260 270 280 290 300 ELARDCLDKS HQGLITSRYF LELQHKLDKL LQEAHDRSES GELAFIKQLV RKILIVIARP 310 320 330 340 350 360 ARLLECLEFD PEEFYYLLEA AEGHAKEGQG IKTDIPRYII SQLGLNKDPL EEMAHLGNYD 370 380 390 400 410 420 SGTAETPETD ESVSSSNASL KLRRKPRESD FETIKLISNG AYGAVYFVRH KESRQRFAMK 430 440 450 460 470 480 KINKQNLILR NQIQQAFVER DILTFAENPF VVSMYCSFET RRHLCMVMEY VEGGDCATLM 490 500 510 520 530 540 KNMGPLPVDM ARMYFAETVL ALEYLHNYGI VHRDLKPDNL LVTSMGHIKL TDFGLSKVGL 550 560 570 580 590 600 MSMTTNLYEG HIEKDAREFL DKQVCGTPEY IAPEVILRQG YGKPVDWWAM GIILYEFLVG 610 620 630 640 650 660 CVPFFGDTPE ELFGQVISDE INWPEKDEAP PPDAQDLITL LLRQNPLERL GTGGAYEVKQ 670 680 690 700 710 720 HRFFRSLDWN SLLRQKAEFI PQLESEDDTS YFDTRSEKYH HMETEEEDDT NDEDFNVEIR 730 740 750 760 770 780 QFSSCSHRFS KVFSSIDRIT QNSAEEKEDS VDKTKSTTLP STETLSWSSE YSEMQQLSTS 790 800 810 820 830 840 NSSDTESNRH KLSSGLLPKL AISTEGEQDE AASCPGDPHE EPGKPALPPE ECAQEEPEVT 850 860 870 880 890 900 TPASTISSST LSVGSFSEHL DQINGRSECV DSTDNSSKPS SEPASHMARQ RLESTEKKKI 910 920 930 940 950 960 SGKVTKSLSA SALSLMIPGD MFAVSPLGSP MSPHSLSSDP SSSRDSSPSR DSSAASASPH 970 980 990 1000 1010 1020 QPIVIHSSGK NYGFTIRAIR VYVGDSDIYT VHHIVWNVEE GSPACQAGLK AGDLITHING 1030 1040 1050 1060 1070 1080 EPVHGLVHTE VIELLLKSGN KVSITTTPFE NTSIKTGPAR RNSYKSRMVR RSKKSKKKES 1090 1100 1110 1120 1130 1140 LERRRSLFKK LAKQPSPLLH TSRSFSCLNR SLSSGESLPG SPTHSLSPRS PTPSYRSTPD 1150 1160 1170 1180 1190 1200 FPSGTNSSQS SSPSSSAPNS PAGSGHIRPS TLHGLAPKLG GQRYRSGRRK SAGNIPLSPL 1210 1220 1230 1240 1250 1260 ARTPSPTPQP TSPQRSPSPL LGHSLGNSKI AQAFPSKMHS PPTIVRHIVR PKSAEPPRSP 1270 1280 1290 1300 1310 1320 LLKRVQSEEK LSPSYGSDKK HLCSRKHSLE VTQEEVQREQ SQREAPLQSL DENVCDVPPL 1330 1340 1350 1360 1370 1380 SRARPVEQGC LKRPVSRKVG RQESVDDLDR DKLKAKVVVK KADGFPEKQE SHQKSHGPGS 1390 1400 1410 1420 1430 1440 DLENFALFKL EEREKKVYPK AVERSSTFEN KASMQEAPPL GSLLKDALHK QASVRASEGA 1450 1460 1470 1480 1490 1500 MSDGPVPAEH RQGGGDFRRA PAPGTLQDGL CHSLDRGISG KGEGTEKSSQ AKELLRCEKL 1510 1520 1530 1540 1550 1560 DSKLANIDYL RKKMSLEDKE DNLCPVLKPK MTAGSHECLP GNPVRPTGGQ QEPPPASESR 1570 1580 1590 1600 1610 1620 AFVSSTHAAQ MSAVSFVPLK ALTGRVDSGT EKPGLVAPES PVRKSPSEYK LEGRSVSCLE 1630 1640 1650 1660 1670 1680 PIEGTLDIAL LSGPQASKTE LPSPESAQSP SPSGDVRASV PPVLPSSSGK KNDTTSAREL 1690 1700 1710 1720 1730 1740 SPSSLKMNKS YLLEPWFLPP SRGLQNSPAV SLPDPEFKRD RKGPHPTARS PGTVMESNPQ 1750 1760 1770 1780 1790 1800 QREGSSPKHQ DHTTDPKLLT CLGQNLHSPD LARPRCPLPP EASPSREKPG LRESSERGPP 1810 1820 1830 1840 1850 1860 TARSERSAAR ADTCREPSME LCFPETAKTS DNSKNLLSVG RTHPDFYTQT QAMEKAWAPG 1870 1880 1890 1900 1910 1920 GKTNHKDGPG EARPPPRDNS SLHSAGIPCE KELGKVRRGV EPKPEALLAR RSLQPPGIES 1930 1940 1950 1960 1970 1980 EKSEKLSSFP SLQKDGAKEP ERKEQPLQRH PSSIPPPPLT AKDLSSPAAR QHCSSPSHAS 1990 2000 2010 2020 2030 2040 GREPGAKPST AEPSSSPQDP PKPVAAHSES SSHKPRPGPD PGPPKTKHPD RSLSSQKPSV 2050 2060 2070 2080 2090 2100 GATKGKEPAT QSLGGSSREG KGHSKSGPDV FPATPGSQNK ASDGIGQGEG GPSVPLHTDR 2110 2120 2130 2140 2150 2160 APLDAKPQPT SGGRPLEVLE KPVHLPRPGH PGPSEPADQK LSAVGEKQTL SPKHPKPSTV 2170 2180 2190 2200 2210 2220 KDCPTLCKQT DNRQTDKSPS QPAANTDRRA EGKKCTEALY APAEGDKLEA GLSFVHSENR 2230 2240 2250 2260 2270 2280 LKGAERPAAG VGKGFPEARG KGPGPQKPPT EADKPNGMKR SPSATGQSSF RSTALPEKSL 2290 2300 2310 2320 2330 2340 SCSSSFPETR AGVREASAAS SDTSSAKAAG GMLELPAPSN RDHRKAQPAG EGRTHMTKSD 2350 2360 2370 2380 2390 2400 SLPSFRVSTL PLESHHPDPN TMGGASHRDR ALSVTATVGE TKGKDPAPAQ PPPARKQNVG 2410 2420 2430 2440 RDVTKPSPAP NTDRPISLSN EKDFVVRQRR GKESLRSSPH KKAL
	Isoform 2 [UniParc]. Checksum: 6D5A72D91BDE95AB		2,429	264,685
	10 20 30 40 50 60 MDMSDPNFWT VLSNFTLPHL RSGNRLRRTQ SCRTSNRKSL IGNGQSPALP RPHSPLSAHA 70 80 90 100 110 120 GNSPQDSPRN FSPSASAHFS FARRTDGRRW SLASLPSSGY GTNTPSSTVS SSCSSQEKLH 130 140 150 160 170 180 QLPYQPTPDE LHFLSKHFCT TESIATENRC RNTPMHPRSR SLSPGRSPAC CDHEIIMMNH 190 200 210 220 230 240 VYKERFPKAT AQMEERLKEI ITSYSPDNVL PLADGVLSFT HHQIIELARD CLDKSHQGLI 250 260 270 280 290 300 TSRYFLELQH KLDKLLQEAH DRSESGELAF IKQLVRKILI VIARPARLLE CLEFDPEEFY 310 320 330 340 350 360 YLLEAAEGHA KEGQGIKTDI PRYIISQLGL NKDPLEEMAH LGNYDSGTAE TPETDESVSS 370 380 390 400 410 420 SNASLKLRRK PRESDFETIK LISNGAYGAV YFVRHKESRQ RFAMKKINKQ NLILRNQIQQ 430 440 450 460 470 480 AFVERDILTF AENPFVVSMY CSFETRRHLC MVMEYVEGGD CATLMKNMGP LPVDMARMYF 490 500 510 520 530 540 AETVLALEYL HNYGIVHRDL KPDNLLVTSM GHIKLTDFGL SKVGLMSMTT NLYEGHIEKD 550 560 570 580 590 600 AREFLDKQVC GTPEYIAPEV ILRQGYGKPV DWWAMGIILY EFLVGCVPFF GDTPEELFGQ 610 620 630 640 650 660 VISDEINWPE KDEAPPPDAQ DLITLLLRQN PLERLGTGGA YEVKQHRFFR SLDWNSLLRQ 670 680 690 700 710 720 KAEFIPQLES EDDTSYFDTR SEKYHHMETE EEDDTNDEDF NVEIRQFSSC SHRFSKVFSS 730 740 750 760 770 780 IDRITQNSAE EKEDSVDKTK STTLPSTETL SWSSEYSEMQ QLSTSNSSDT ESNRHKLSSG 790 800 810 820 830 840 LLPKLAISTE GEQDEAASCP GDPHEEPGKP ALPPEECAQE EPEVTTPAST ISSSTLSVGS 850 860 870 880 890 900 FSEHLDQING RSECVDSTDN SSKPSSEPAS HMARQRLEST EKKKISGKVT KSLSASALSL 910 920 930 940 950 960 MIPGDMFAVS PLGSPMSPHS LSSDPSSSRD SSPSRDSSAA SASPHQPIVI HSSGKNYGFT 970 980 990 1000 1010 1020 IRAIRVYVGD SDIYTVHHIV WNVEEGSPAC QAGLKAGDLI THINGEPVHG LVHTEVIELL 1030 1040 1050 1060 1070 1080 LKSGNKVSIT TTPFENTSIK TGPARRNSYK SRMVRRSKKS KKKESLERRR SLFKKLAKQP 1090 1100 1110 1120 1130 1140 SPLLHTSRSF SCLNRSLSSG ESLPGSPTHS LSPRSPTPSY RSTPDFPSGT NSSQSSSPSS 1150 1160 1170 1180 1190 1200 SAPNSPAGSG HIRPSTLHGL APKLGGQRYR SGRRKSAGNI PLSPLARTPS PTPQPTSPQR 1210 1220 1230 1240 1250 1260 SPSPLLGHSL GNSKIAQAFP SKMHSPPTIV RHIVRPKSAE PPRSPLLKRV QSEEKLSPSY 1270 1280 1290 1300 1310 1320 GSDKKHLCSR KHSLEVTQEE VQREQSQREA PLQSLDENVC DVPPLSRARP VEQGCLKRPV 1330 1340 1350 1360 1370 1380 SRKVGRQESV DDLDRDKLKA KVVVKKADGF PEKQESHQKS HGPGSDLENF ALFKLEEREK 1390 1400 1410 1420 1430 1440 KVYPKAVERS STFENKASMQ EAPPLGSLLK DALHKQASVR ASEGAMSDGP VPAEHRQGGG 1450 1460 1470 1480 1490 1500 DFRRAPAPGT LQDGLCHSLD RGISGKGEGT EKSSQAKELL RCEKLDSKLA NIDYLRKKMS 1510 1520 1530 1540 1550 1560 LEDKEDNLCP VLKPKMTAGS HECLPGNPVR PTGGQQEPPP ASESRAFVSS THAAQMSAVS 1570 1580 1590 1600 1610 1620 FVPLKALTGR VDSGTEKPGL VAPESPVRKS PSEYKLEGRS VSCLEPIEGT LDIALLSGPQ 1630 1640 1650 1660 1670 1680 ASKTELPSPE SAQSPSPSGD VRASVPPVLP SSSGKKNDTT SARELSPSSL KMNKSYLLEP 1690 1700 1710 1720 1730 1740 WFLPPSRGLQ NSPAVSLPDP EFKRDRKGPH PTARSPGTVM ESNPQQREGS SPKHQDHTTD 1750 1760 1770 1780 1790 1800 PKLLTCLGQN LHSPDLARPR CPLPPEASPS REKPGLRESS ERGPPTARSE RSAARADTCR 1810 1820 1830 1840 1850 1860 EPSMELCFPE TAKTSDNSKN LLSVGRTHPD FYTQTQAMEK AWAPGGKTNH KDGPGEARPP 1870 1880 1890 1900 1910 1920 PRDNSSLHSA GIPCEKELGK VRRGVEPKPE ALLARRSLQP PGIESEKSEK LSSFPSLQKD 1930 1940 1950 1960 1970 1980 GAKEPERKEQ PLQRHPSSIP PPPLTAKDLS SPAARQHCSS PSHASGREPG AKPSTAEPSS 1990 2000 2010 2020 2030 2040 SPQDPPKPVA AHSESSSHKP RPGPDPGPPK TKHPDRSLSS QKPSVGATKG KEPATQSLGG 2050 2060 2070 2080 2090 2100 SSREGKGHSK SGPDVFPATP GSQNKASDGI GQGEGGPSVP LHTDRAPLDA KPQPTSGGRP 2110 2120 2130 2140 2150 2160 LEVLEKPVHL PRPGHPGPSE PADQKLSAVG EKQTLSPKHP KPSTVKDCPT LCKQTDNRQT 2170 2180 2190 2200 2210 2220 DKSPSQPAAN TDRRAEGKKC TEALYAPAEG DKLEAGLSFV HSENRLKGAE RPAAGVGKGF 2230 2240 2250 2260 2270 2280 PEARGKGPGP QKPPTEADKP NGMKRSPSAT GQSSFRSTAL PEKSLSCSSS FPETRAGVRE 2290 2300 2310 2320 2330 2340 ASAASSDTSS AKAAGGMLEL PAPSNRDHRK AQPAGEGRTH MTKSDSLPSF RVSTLPLESH 2350 2360 2370 2380 2390 2400 HPDPNTMGGA SHRDRALSVT ATVGETKGKD PAPAQPPPAR KQNVGRDVTK PSPAPNTDRP 2410 2420 ISLSNEKDFV VRQRRGKESL RSSPHKKAL
	Isoform 3 [UniParc]. Checksum: 449D8A89F4450FDD		2,434	265,276
	10 20 30 40 50 60 MDESSILRRR GLQKELSLPR RGSLIDSQKW NCLVKRCRTS NRKSLIGNGQ SPALPRPHSP 70 80 90 100 110 120 LSAHAGNSPQ DSPRNFSPSA SAHFSFARRT DGRRWSLASL PSSGYGTNTP SSTVSSSCSS 130 140 150 160 170 180 QEKLHQLPYQ PTPDELHFLS KHFCTTESIA TENRCRNTPM HPRSRSLSPG RSPACCDHEI 190 200 210 220 230 240 IMMNHVYKER FPKATAQMEE RLKEIITSYS PDNVLPLADG VLSFTHHQII ELARDCLDKS 250 260 270 280 290 300 HQGLITSRYF LELQHKLDKL LQEAHDRSES GELAFIKQLV RKILIVIARP ARLLECLEFD 310 320 330 340 350 360 PEEFYYLLEA AEGHAKEGQG IKTDIPRYII SQLGLNKDPL EEMAHLGNYD SGTAETPETD 370 380 390 400 410 420 ESVSSSNASL KLRRKPRESD FETIKLISNG AYGAVYFVRH KESRQRFAMK KINKQNLILR 430 440 450 460 470 480 NQIQQAFVER DILTFAENPF VVSMYCSFET RRHLCMVMEY VEGGDCATLM KNMGPLPVDM 490 500 510 520 530 540 ARMYFAETVL ALEYLHNYGI VHRDLKPDNL LVTSMGHIKL TDFGLSKVGL MSMTTNLYEG 550 560 570 580 590 600 HIEKDAREFL DKQVCGTPEY IAPEVILRQG YGKPVDWWAM GIILYEFLVG CVPFFGDTPE 610 620 630 640 650 660 ELFGQVISDE INWPEKDEAP PPDAQDLITL LLRQNPLERL GTGGAYEVKQ HRFFRSLDWN 670 680 690 700 710 720 SLLRQKAEFI PQLESEDDTS YFDTRSEKYH HMETEEEDDT NDEDFNVEIR QFSSCSHRFS 730 740 750 760 770 780 KVFSSIDRIT QNSAEEKEDS VDKTKSTTLP STETLSWSSE YSEMQQLSTS NSSDTESNRH 790 800 810 820 830 840 KLSSGLLPKL AISTEGEQDE AASCPGDPHE EPGKPALPPE ECAQEEPEVT TPASTISSST 850 860 870 880 890 900 LSVGSFSEHL DQINGRSECV DSTDNSSKPS SEPASHMARQ RLESTEKKKI SGKVTKSLSA 910 920 930 940 950 960 SALSLMIPGD MFAVSPLGSP MSPHSLSSDP SSSRDSSPSR DSSAASASPH QPIVIHSSGK 970 980 990 1000 1010 1020 NYGFTIRAIR VYVGDSDIYT VHHIVWNVEE GSPACQAGLK AGDLITHING EPVHGLVHTE 1030 1040 1050 1060 1070 1080 VIELLLKSGN KVSITTTPFE NTSIKTGPAR RNSYKSRMVR RSKKSKKKES LERRRSLFKK 1090 1100 1110 1120 1130 1140 LAKQPSPLLH TSRSFSCLNR SLSSGESLPG SPTHSLSPRS PTPSYRSTPD FPSGTNSSQS 1150 1160 1170 1180 1190 1200 SSPSSSAPNS PAGSGHIRPS TLHGLAPKLG GQRYRSGRRK SAGNIPLSPL ARTPSPTPQP 1210 1220 1230 1240 1250 1260 TSPQRSPSPL LGHSLGNSKI AQAFPSKMHS PPTIVRHIVR PKSAEPPRSP LLKRVQSEEK 1270 1280 1290 1300 1310 1320 LSPSYGSDKK HLCSRKHSLE VTQEEVQREQ SQREAPLQSL DENVCDVPPL SRARPVEQGC 1330 1340 1350 1360 1370 1380 LKRPVSRKVG RQESVDDLDR DKLKAKVVVK KADGFPEKQE SHQKSHGPGS DLENFALFKL 1390 1400 1410 1420 1430 1440 EEREKKVYPK AVERSSTFEN KASMQEAPPL GSLLKDALHK QASVRASEGA MSDGPVPAEH 1450 1460 1470 1480 1490 1500 RQGGGDFRRA PAPGTLQDGL CHSLDRGISG KGEGTEKSSQ AKELLRCEKL DSKLANIDYL 1510 1520 1530 1540 1550 1560 RKKMSLEDKE DNLCPVLKPK MTAGSHECLP GNPVRPTGGQ QEPPPASESR AFVSSTHAAQ 1570 1580 1590 1600 1610 1620 MSAVSFVPLK ALTGRVDSGT EKPGLVAPES PVRKSPSEYK LEGRSVSCLE PIEGTLDIAL 1630 1640 1650 1660 1670 1680 LSGPQASKTE LPSPESAQSP SPSGDVRASV PPVLPSSSGK KNDTTSAREL SPSSLKMNKS 1690 1700 1710 1720 1730 1740 YLLEPWFLPP SRGLQNSPAV SLPDPEFKRD RKGPHPTARS PGTVMESNPQ QREGSSPKHQ 1750 1760 1770 1780 1790 1800 DHTTDPKLLT CLGQNLHSPD LARPRCPLPP EASPSREKPG LRESSERGPP TARSERSAAR 1810 1820 1830 1840 1850 1860 ADTCREPSME LCFPETAKTS DNSKNLLSVG RTHPDFYTQT QAMEKAWAPG GKTNHKDGPG 1870 1880 1890 1900 1910 1920 EARPPPRDNS SLHSAGIPCE KELGKVRRGV EPKPEALLAR RSLQPPGIES EKSEKLSSFP 1930 1940 1950 1960 1970 1980 SLQKDGAKEP ERKEQPLQRH PSSIPPPPLT AKDLSSPAAR QHCSSPSHAS GREPGAKPST 1990 2000 2010 2020 2030 2040 AEPSSSPQDP PKPVAAHSES SSHKPRPGPD PGPPKTKHPD RSLSSQKPSV GATKGKEPAT 2050 2060 2070 2080 2090 2100 QSLGGSSREG KGHSKSGPDV FPATPGSQNK ASDGIGQGEG GPSVPLHTDR APLDAKPQPT 2110 2120 2130 2140 2150 2160 SGGRPLEVLE KPVHLPRPGH PGPSEPADQK LSAVGEKQTL SPKHPKPSTV KDCPTLCKQT 2170 2180 2190 2200 2210 2220 DNRQTDKSPS QPAANTDRRA EGKKCTEALY APAEGDKLEA GLSFVHSENR LKGAERPAAG 2230 2240 2250 2260 2270 2280 VGKGFPEARG KGPGPQKPPT EADKPNGMKR SPSATGQSSF RSTALPEKSL SCSSSFPETR 2290 2300 2310 2320 2330 2340 AGVREASAAS SDTSSAKAAG GMLELPAPSN RDHRKAQPAG EGRTHMTKSD SLPSFRVSTL 2350 2360 2370 2380 2390 2400 PLESHHPDPN TMGGASHRDR ALSVTATVGE TKGKDPAPAQ PPPARKQNVG RDVTKPSPAP 2410 2420 2430 NTDRPISLSN EKDFVVRQRR GKESLRSSPH KKAL

References

[1]	"Identification of a novel human MAST4 gene, a new member of the microtubule associated serine-threonine kinase family." Sun L., Gu S., Li X., Sun Y., Zheng D., Yu K., Ji C., Tang R., Xie Y., Mao Y. Mol. Biol. (Mosk.) 40:808-815(2006) [PubMed: 17086981] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-505 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-484 (ISOFORM 2). Tissue: Brain and Thymus.
[3]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 308-2444 (ISOFORM 1). Tissue: Brain.
[4]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1733 AND SER-1737, MASS SPECTROMETRY. Tissue: Epithelium.
[5]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1240, MASS SPECTROMETRY.
[6]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-741; TRP-1775; LEU-2019; CYS-2111 AND ASP-2288.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY830839 mRNA. Translation: AAW52510.1. AK057601 mRNA. Translation: BAB71532.1. AK131421 mRNA. Translation: BAD18568.1. AB002301 mRNA. Translation: BAA20762.1.
RefSeq	NP_055998.1.
UniGene	Hs.595458
3D structure databases
HSSP	HSSP built from PDB template 1MRY based on UniProtKB P31751.
ModBase	Search...
PTM databases
PhosphoSite	O15021.
Genome annotation databases
Ensembl	ENSG00000069020. Homo sapiens. [Contig view]
GeneID	375449.
KEGG	hsa:375449.
Organism-specific databases
HGNC	HGNC:19037. MAST4.
HPA	HPA000544.
PharmGKB	PA134920494.
HUGE	Search...
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOVERGEN	O15021.
Gene expression databases
ArrayExpress	O15021.
CleanEx	HS_MAST4.
GermOnline	ENSG00000069020. Homo sapiens.
Family and domain databases
InterPro	IPR015022. DUF1908. IPR001478. PDZ. IPR000961. Pkinase_C. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF08926. DUF1908. 1 hit. PF00595. PDZ. 1 hit. PF00069. Pkinase. 1 hit. PF00433. Pkinase_C. 1 hit. [