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Reviewed, UniProtKB/Swiss-Prot O15072 (ATS3_HUMAN)

Last modified July 22, 2008. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    ADAMTS-3
    EC=3.4.24.-
Alternative name(s):
    A disintegrin and metalloproteinase with thrombospondin motifs 3
      Short name(s)=ADAM-TS 3, ADAM-TS3
    Procollagen II amino propeptide-processing enzyme
    Procollagen II N-proteinase
      Short name(s)=PC II-NP
Gene names
Name: ADAMTS3
Synonyms: KIAA0366
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length1205 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Secreted › extracellular space › extracellular matrixBy similarity.

Tissue specificity

Found in cartilage and skin.

Domain

The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.

Post-translational modification

The precursor is cleaved by a furin endopeptidase By similarity.

Sequence similarities

Contains 1 disintegrin domain.

Contains 1 peptidase M12B domain.

Contains 1 PLAC domain.

Contains 4 TSP type-1 domains.

Caution

Has sometimes been referred to as ADAMTS4.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Signal peptide1 – 2020 Potential
Propeptide21 – 249229 By similarity
Chain250 – 1205956ADAMTS-3

Regions

Domain256 – 460205Peptidase M12B
Domain470 – 55081Disintegrin
Domain551 – 60656TSP type-1 1
Domain845 – 90561TSP type-1 2
Domain906 – 96560TSP type-1 3
Domain966 – 101449TSP type-1 4
Domain1015 – 105440PLAC
Region713 – 844132Spacer
Compositional bias246 – 2494Poly-Arg
Compositional bias608 – 712105Cys-rich

Sites

Active site3991 By similarity
Metal binding3981Zinc (catalytic) By similarity
Metal binding4021Zinc (catalytic) By similarity
Metal binding4081Zinc (catalytic) By similarity

Amino acid modifications

Glycosylation831N-linked (GlcNAc...) Potential
Glycosylation1191N-linked (GlcNAc...) Potential
Glycosylation2421N-linked (GlcNAc...) Potential
Glycosylation3451N-linked (GlcNAc...) Potential
Glycosylation4751N-linked (GlcNAc...) Potential
Glycosylation8141N-linked (GlcNAc...) Potential
Glycosylation9421N-linked (GlcNAc...) Potential
Disulfide bond376 ↔ 455 By similarity
Disulfide bond415 ↔ 441 By similarity
Disulfide bond563 ↔ 600 By similarity
Disulfide bond567 ↔ 605 By similarity
Disulfide bond578 ↔ 590 By similarity
Disulfide bond978 ↔ 1010 By similarity
Disulfide bond982 ↔ 1015 By similarity
Disulfide bond993 ↔ 999 By similarity

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Sequences

Sequence LengthMass (Da)Tools
O15072-1 [UniParc].

Last modified July 11, 2002. Version 2.
Checksum: EB07B286FC85FB87

FASTA1,205135,571
        10         20         30         40         50         60 
MVLLSLWLIA AALVEVRTSA DGQAGNEEMV QIDLPIKRYR EYELVTPVST NLEGRYLSHT 

        70         80         90        100        110        120 
LSASHKKRSA RDVSSNPEQL FFNITAFGKD FHLRLKPNTQ LVAPGAVVEW HETSLVPGNI 

       130        140        150        160        170        180 
TDPINNHQPG SATYRIRKTE PLQTNCAYVG DIVDIPGTSV AISNCDGLAG MIKSDNEEYF 

       190        200        210        220        230        240 
IEPLERGKQM EEEKGRIHVV YKRSAVEQAP IDMSKDFHYR ESDLEGLDDL GTVYGNIHQQ 

       250        260        270        280        290        300 
LNETMRRRRH AGENDYNIEV LLGVDDSVVR FHGKEHVQNY LLTLMNIVNE IYHDESLGVH 

       310        320        330        340        350        360 
INVVLVRMIM LGYAKSISLI ERGNPSRSLE NVCRWASQQQ RSDLNHSEHH DHAIFLTRQD 

       370        380        390        400        410        420 
FGPAGMQGYA PVTGMCHPVR SCTLNHEDGF SSAFVVAHET GHVLGMEHDG QGNRCGDETA 

       430        440        450        460        470        480 
MGSVMAPLVQ AAFHRYHWSR CSGQELKRYI HSYDCLLDDP FDHDWPKLPE LPGINYSMDE 

       490        500        510        520        530        540 
QCRFDFGVGY KMCTAFRTFD PCKQLWCSHP DNPYFCKTKK GPPLDGTECA AGKWCYKGHC 

       550        560        570        580        590        600 
MWKNANQQKQ DGNWGSWTKF GSCSRTCGTG VRFRTRQCNN PMPINGGQDC PGVNFEYQLC 

       610        620        630        640        650        660 
NTEECQKHFE DFRAQQCQQR NSHFEYQNTK HHWLPYEHPD PKKRCHLYCQ SKETGDVAYM 

       670        680        690        700        710        720 
KQLVHDGTHC SYKDPYSICV RGECVKVGCD KEIGSNKVED KCGVCGGDNS HCRTVKGTFT 

       730        740        750        760        770        780 
RTPRKLGYLK MFDIPPGARH VLIQEDEASP HILAIKNQAT GHYILNGKGE EAKSRTFIDL 

       790        800        810        820        830        840 
GVEWDYNIED DIESLHTDGP LHDPVIVLII PQENDTRSSL TYKYIIHEDS VPTINSNNVI 

       850        860        870        880        890        900 
QEELDTFEWA LKSWSQVSKP CGGGFQYTKY GCRRKSDNKM VHRSFCEANK KPKPIRRMCN 

       910        920        930        940        950        960 
IQECTHPLWV AEEWEHCTKT CGSSGYQLRT VRCLQPLLDG TNRSVHSKYC MGDRPESRRP 

       970        980        990       1000       1010       1020 
CNRVPCPAQW KTGPWSECSV TCGEGTEVRQ VLCRAGDHCD GEKPESVRAC QLPPCNDEPC 

      1030       1040       1050       1060       1070       1080 
LGDKSIFCQM EVLARYCSIP GYNKLCCESC SKRSSTLPPP YLLEAAETHD DVISNPSDLP 

      1090       1100       1110       1120       1130       1140 
RSLVMPTSLV PYHSETPAKK MSLSSISSVG GPNAYAAFRP NSKPDGANLR QRSAQQAGSK 

      1150       1160       1170       1180       1190       1200 
TVRLVTVPSS PPTKRVHLSS ASQMAAASFF AASDSIGASS QARTSKKDGK IIDNRRPTRS 


STLER

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References

« Hide 'large scale' references
[1]"Procollagen II amino propeptide processing by ADAMTS-3. Insights on dermatosparaxis."
Fernandes R.J., Hirohata S., Engle J.M., Colige A., Cohn D.H., Eyre D.R., Apte S.S.
J. Biol. Chem. 276:31502-31509(2001) [PubMed: 11408482] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-227.
[2]"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-1205.
Tissue: Brain.

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Cross-references

Sequence databases

AF247668 mRNA. Translation: AAK28400.1.
AB002364 mRNA. Translation: BAA20821.1.
RefSeqNP_055058.1.
UniGeneHs.590919

3D structure databases

HSSPHSSP built from PDB template 1LSL based on UniProtKB P07996.
ModBaseSearch...

Protein family/group databases

MEROPSM12.220.

Genome annotation databases

EnsemblENSG00000156140. Homo sapiens. [Contig view]
GeneID9508.
KEGGhsa:9508.

Organism-specific databases

H-InvDBHIX0004274.
HGNCHGNC:219. ADAMTS3.
MIM605011. gene.
PharmGKBPA24547.
HUGESearch...
GenAtlasSearch...
GeneCardsSearch...
GeneLynxSearch...

Phylogenomic databases

HOGENOMO15072.
HOVERGENO15072.

Gene expression databases

ArrayExpressO15072.
CleanExHS_ADAMTS3.
GermOnlineENSG00000156140. Homo sapiens.

Family and domain databases

InterProIPR010294. ADAM_spacer1.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR006025. Pept_M_Zn_BS.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR010909. PLAC.
IPR000884. TSP1.
IPR008085. TSP_1.
[Graphical view]
PfamPF05986. ADAM_spacer1. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 4 hits.
[Graphical view]
PRINTSPR01857. ADAMTSFAMILY.
PR01705. TSP1REPEAT.
SMARTSM00209. TSP1. 4 hits.
[Graphical view]
PROSITEPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. False negative.
PS50214. DISINTEGRIN_2. False negative.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 4 hits.
PS00142. ZINC_PROTEASE. False negative.
[Graphical view]
ProDomO15072.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

SOURCESearch...
ProtoNetSearch...

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Entry information

Entry nameATS3_HUMAN
AccessionPrimary (citable) accession number: O15072
Secondary accession number(s): Q9BXZ8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 11, 2002
Last modified: July 22, 2008
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Peptidase families

Classification of peptidase families and list of entries

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents