Reviewed, UniProtKB/Swiss-Prot O15204 (ADEC1_HUMAN)

Names and origin

Protein names

Recommended name:
    ADAM DEC1
    EC=3.4.24.-
Alternative name(s):
    A disintegrin and metalloproteinase domain-like protein decysin 1
      Short name=ADAM-like protein decysin 1

Gene names

Name:

ADAMDEC1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play an important role in the control of the immune response and during pregnancy By similarity.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subcellular location	SecretedBy similarity.
Tissue specificity	Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC) of the germinal center. Weakly expressed in monocyte and highly expressed in macrophage. Absent in immature DC. Ref.1 Ref.3
Induction	Induced during DC maturation and up-regulated in response to T-cell signals. In macrophage up-regulated by lipopolysaccharide (LPS). Up-regulated by 1 alpha, 25 dihydroxyvitamin D3 during differentiation of primary monocyte into macrophage. Ref.1 Ref.3
Sequence similarities	Contains 1 disintegrin domain. Contains 1 peptidase M12B domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
PTM	Glycoprotein Zymogen
Gene Ontology (GO)
Biological process	integrin-mediated signaling pathway Non-traceable author statement. Source: UniProtKB negative regulation of cell adhesion Ref.1 Non-traceable author statement. Source: UniProtKB proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Non-traceable author statement. Source: UniProtKB
Molecular function	integrin binding Non-traceable author statement. Source: UniProtKB metalloendopeptidase activity Ref.1 Non-traceable author statement. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Propeptide	31 – 205	175	Potential		PRO_0000029146
	Chain	206 – 470	265	ADAM DEC1		PRO_0000029147
Regions
	Domain	218 – 412	195	Peptidase M12B
	Domain	420 – 470	51	Disintegrin
Sites
	Active site	353	1	By similarity
	Metal binding	352	1	Zinc; catalytic By similarity
	Metal binding	356	1	Zinc; catalytic By similarity
	Metal binding	362	1	Zinc; catalytic Potential
Amino acid modifications
	Glycosylation	61	1	N-linked (GlcNAc...) Potential
	Glycosylation	184	1	N-linked (GlcNAc...) Potential
	Glycosylation	237	1	N-linked (GlcNAc...) Ref.4
	Glycosylation	466	1	N-linked (GlcNAc...) Potential
	Disulfide bond	328 ↔ 407		By similarity
	Disulfide bond	369 ↔ 374		By similarity
Natural variations
	Natural variant	121	1	M → T: dbSNP rs7007084.		VAR_024598
	Natural variant	444	1	N → S: dbSNP rs3765124.		VAR_021848

Sequences

	Sequence		Length	Mass (Da)
	O15204-1 [UniParc]. Last modified November 1, 1999. Version 2. Checksum: 35A454DD8A6A7E53	FASTA	470	52,775
	10 20 30 40 50 60 MLRGISQLPA VATMSWVLLP VLWLIVQTQA IAIKQTPELT LHEIVCPKKL HILHKREIKN 70 80 90 100 110 120 NQTEKHGKEE RYEPEVQYQM ILNGEEIILS LQKTKHLLGP DYTETLYSPR GEEITTKPEN 130 140 150 160 170 180 MEHCYYKGNI LNEKNSVASI STCDGLRGYF THHHQRYQIK PLKSTDEKEH AVFTSNQEEQ 190 200 210 220 230 240 DPANHTCGVK STDGKQGPIR ISRSLKSPEK EDFLRAQKYI DLYLVLDNAF YKNYNENLTL 250 260 270 280 290 300 IRSFVFDVMN LLNVIYNTID VQVALVGMEI WSDGDKIKVV PSASTTFDNF LRWHSSNLGK 310 320 330 340 350 360 KIHDHAQLLS GISFNNRRVG LAASNSLCSP SSVAVIEAKK KNNVALVGVM SHELGHVLGM 370 380 390 400 410 420 PDVPFNTKCP SGSCVMNQYL SSKFPKDFST SCRAHFERYL LSQKPKCLLQ APIPTNIMTT 430 440 450 460 470 PVCGNHLLEV GEDCDCGSPK ECTNLCCEAL TCKLKPGTDC GGDAPNHTTE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells." Mueller C.G.F., Rissoan M.C., Salinas B., Ait-Yahia S., Ravel O., Bridon J.-M., Briere F., Lebecque S., Liu Y.J. J. Exp. Med. 186:655-663(1997) [PubMed: 9271581] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	"Inverse regulation of the ADAM-family members, decysin and MADDAM/ADAM19 during monocyte differentiation." Fritsche J., Muller A., Hausmann M., Rogler G., Andreesen R., Kreutz M. Immunology 110:450-457(2003) [PubMed: 14632642] [Abstract] Cited for: TISSUE SPECIFICITY, INDUCTION.
[4]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-237, MASS SPECTROMETRY. Tissue: Plasma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y13323 mRNA. Translation: CAA73764.2. BC069582 mRNA. Translation: AAH69582.1. BC074877 mRNA. Translation: AAH74877.1. BC074878 mRNA. Translation: AAH74878.1.
RefSeq	NP_055294.1.
UniGene	Hs.521459
3D structure databases
HSSP	HSSP built from PDB template 1J2L based on UniProtKB P21859.
ModBase	Search...
Protein family/group databases
MEROPS	M12.219.
Proteomic databases
PeptideAtlas	O15204.
PRIDE	O15204.
Genome annotation databases
Ensembl	ENSG00000134028. Homo sapiens. [Contig view]
GeneID	27299.
KEGG	hsa:27299.
Organism-specific databases
GeneCards	GC08P024297.
H-InvDB	HIX0034353.
HGNC	HGNC:16299. ADAMDEC1.
MIM	606393. gene.
PharmGKB	PA24535.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O15204.
HOVERGEN	O15204.
Gene expression databases
ArrayExpress	O15204.
CleanEx	HS_ADAMDEC1.
GermOnline	ENSG00000134028. Homo sapiens.
Family and domain databases
InterPro	IPR001762. Blood-coag_inhib_Disintegrin. IPR001818. Pept_M10A_M12B. IPR006025. Pept_M_Zn_BS. IPR001590. Peptidase_M12B. IPR002870. Peptidase_M12B_N. [Graphical view]
Pfam	PF00200. Disintegrin. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit. [Graphical view]
SMART	SM00050. DISIN. 1 hit. [Graphical view]
PROSITE	PS50215. ADAM_MEPRO. 1 hit. PS00546. CYSTEINE_SWITCH. False negative. PS00427. DISINTEGRIN_1. False negative. PS50214. DISINTEGRIN_2. 1 hit. PS00142. ZINC_PROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	50277.
SOURCE	Search...

Entry information

Entry name

ADEC1_HUMAN

Accession

Primary (citable) accession number: O15204

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	November 1, 1999
Last modified:	December 16, 2008
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)