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Reviewed, UniProtKB/Swiss-Prot O15254 (ACOX3_HUMAN)

Last modified July 22, 2008. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Peroxisomal acyl-coenzyme A oxidase 3
    EC=1.3.3.6
Alternative name(s):
    Pristanoyl-CoA oxidase
    Branched-chain acyl-CoA oxidase
      Short name=BRCACox
Gene names
Name: ACOX3
Synonyms: BRCOX, PRCOX
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length700 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Oxidizes the CoA-esters of 2-methyl-branched fatty acids By similarity.

Catalytic activity

Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2).

Cofactor

FAD By similarity.

Pathway

Lipid metabolism; peroxisomal fatty acid beta-oxidation.

Subcellular location

PeroxisomePotential.

Sequence similarities

Belongs to the acyl-CoA oxidase family.

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Ontologies

Keywords

   Biological processFatty acid metabolism
Lipid metabolism
   Cellular componentPeroxisome
   Coding sequence diversityAlternative splicing
Polymorphism
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase

Gene Ontology (GO)

   Biological processbile acid metabolic process Ref.1

Traceable author statement. Source: ProtInc

fatty acid metabolic process Ref.1

Traceable author statement. Source: ProtInc

   Cellular componentperoxisome Ref.1

Traceable author statement. Source: ProtInc

   Molecular functionacyl-CoA oxidase activity Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O15254-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O15254-2)

The sequence of this isoform differs from the canonical sequence as follows:
     610-624: GGYFSGEQAGEVLES → AERRCSCPGRRDRSS
     625-700: Missing.
Notes: No experimental confirmation available.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 700700Peroxisomal acyl-coenzyme A oxidase 3

Regions

Motif698 – 7003Microbody targeting signal By similarity
Compositional bias340 – 3434Poly-Glu

Natural variations

Alternative sequence610 – 62415GGYFS…EVLES → AERRCSCPGRRDRSS in isoform 2.
Alternative sequence625 – 70076Missing in isoform 2.
Natural variant341E → A: dbSNP rs12513296.
Natural variant4971D → N: dbSNP rs13434465.

Experimental info

Sequence conflict34 – 352EL → DV in CAA72214. Ref.1
Sequence conflict44 – 452ML → NV in CAA72214. Ref.1
Sequence conflict951D → A in CAA72214. Ref.1
Sequence conflict3651A → G in CAA72214. Ref.1
Sequence conflict6011S → K in CAA72214. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 20, 2007. Version 2.
Checksum: 40D1CD3DC6A620C1

FASTA70077,629
        10         20         30         40         50         60 
MASTVEGGDT ALLPEFPRGP LDAYRARASF SWKELALFTE GEGMLRFKKT IFSALENDPL 

        70         80         90        100        110        120 
FARSPGADLS LEKYRELNFL RCKRIFEYDF LSVEDMFKSP LKVPALIQCL GMYDSSLAAK 

       130        140        150        160        170        180 
YLLHSLVFGS AVYSSGSERH LTYIQKIFRM EIFGCFALTE LSHGSNTKAI RTTAHYDPAT 

       190        200        210        220        230        240 
EEFIIHSPDF EAAKFWVGNM GKTATHAVVF AKLCVPGDQC HGLHPFIVQI RDPKTLLPMP 

       250        260        270        280        290        300 
GVMVGDIGKK LGQNGLDNGF AMFHKVRVPR QSLLNRMGDV TPEGTYVSPF KDVRQRFGAS 

       310        320        330        340        350        360 
LGSLSSGRVS IVSLAILNLK LAVAIALRFS ATRRQFGPTE EEEIPVLEYP MQQWRLLPYL 

       370        380        390        400        410        420 
AAVYALDHFS KSLFLDLVEL QRGLASGDRS ARQAELGREI HALASASKPL ASWTTQQGIQ 

       430        440        450        460        470        480 
ECREACGGHG YLAMNRLGVL RDDNDPNCTY EGDNNILLQQ TSNYLLGLLA HQVHDGACFR 

       490        500        510        520        530        540 
SPLKSVDFLD AYPGILDQKF EVSSVADCLD SAVALAAYKW LVCYLLRETY QKLNQEKRSG 

       550        560        570        580        590        600 
SSDFEARNKC QVSHGRPLAL AFVELTVVQR FHEHVHQPSV PPSLRAVLGR LSALYALWSL 

       610        620        630        640        650        660 
SRHAALLYRG GYFSGEQAGE VLESAVLALC SQLKDDAVAL VDVIAPPDFV LDSPIGRADG 

       670        680        690        700 
ELYKNLWGAV LQESKVLERA SWWPEFSVNK PVIGSLKSKL

« Hide

Isoform 2 [UniParc].

Checksum: 1894338CCBF1939A
Show »

62469,575

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References

« Hide 'large scale' references
[1]"Evidence for the existence of a pristanoyl-CoA oxidase gene in man."
Vanhooren J.C.T., Marynen P., Mannaerts G.P., van Veldhoven P.P.
Biochem. J. 325:593-599(1997) [PubMed: 9271077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Uterus.
+Additional computationally mapped references.

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Cross-references

Sequence databases

Y11411 mRNA. Translation: CAA72214.1.
BC017053 mRNA. Translation: AAH17053.1.
RefSeqNP_001095137.1.
NP_003492.2.
UniGeneHs.479122

3D structure databases

HSSPHSSP built from PDB template 1IS2 based on UniProtKB P07872.
ModBaseSearch...

Protein-protein interaction databases

IntActO15254.

Genome annotation databases

EnsemblENSG00000087008. Homo sapiens. [Contig view]
GeneID8310.
KEGGhsa:8310.

Organism-specific databases

H-InvDBHIX0004086.
HGNCHGNC:121. ACOX3.
MIM603402. gene.
PharmGKBPA24445.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMO15254.
HOVERGENO15254.

Gene expression databases

ArrayExpressO15254.
CleanExHS_ACOX3.
GermOnlineENSG00000087008. Homo sapiens.

Family and domain databases

InterProIPR006091. Acyl-CoA_DHase/Oxase_M.
IPR006090. Acyl-CoA_Oxase/DHase_1.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl_CoA_ox_C.
IPR013786. AcylCoA_DH/ox_N.
IPR013764. AcylCoA_oxidase/DH_1/2_C.
[Graphical view]
Gene3DG3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit.
G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit.
G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 2 hits.
PANTHERPTHR10909:SF11. Acyl-CoA_oxidase. 1 hit.
PfamPF01756. ACOX. 1 hit.
PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
[Graphical view]
PIRSFPIRSF000168. Acyl-CoA_oxidase. 1 hit.
ProDomO15254.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

SOURCESearch...
ProtoNetSearch...

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Entry information

Entry nameACOX3_HUMAN
AccessionPrimary (citable) accession number: O15254
Secondary accession number(s): Q96AJ8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: February 20, 2007
Last modified: July 22, 2008
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents