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UniProtKB/Swiss-Prot O15438 (MRP3_HUMAN)
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December 16, 2008.
Version 84.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Canalicular multispecific organic anion transporter 2 Alternative name(s): ATP-binding cassette sub-family C member 3 Multidrug resistance-associated protein 3 Multi-specific organic anion transporter D Short name=MOAT-D | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1527 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes By similarity. |
| Subcellular location | |
| Tissue specificity | Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney. |
| Sequence similarities | Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains. |
Ontologies
Keywords | |
|---|---|
| Biological process | Transport |
| Cellular component | Membrane |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Repeat Transmembrane |
| Ligand | ATP-binding Nucleotide-binding |
| PTM | Glycoprotein Phosphoprotein |
Gene Ontology (GO) | |
| Biological process | transport Ref.3 Traceable author statement. Source: ProtInc |
| Cellular component | integral to plasma membrane Ref.3 Traceable author statement. Source: ProtInc membrane fraction Ref.3Traceable author statement. Source: ProtInc |
| Molecular function | ATP binding Ref.3 Traceable author statement. Source: ProtInc ATPase activity, coupled to transmembrane movement of substances Ref.3Traceable author statement. Source: ProtInc organic anion transmembrane transporter activity Ref.1Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Alternative products
| This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] Notes: Additional isoforms seem to exist. | ||||||
| Isoform 3 (identifier: O15438-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 3A (identifier: O15438-2) The sequence of this isoform differs from the canonical sequence as follows: 1194-1527: WLSIGVEFVG...YGMARDAGLA → SEAASLAPCS...ALPLPHFLLI | ||||||
| Notes: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. | ||||||
| Isoform 3B (identifier: O15438-3) The sequence of this isoform differs from the canonical sequence as follows: 226-510: MAIYGYRHPL...LKLYAWEPSF → LLNPDPLRGC...IEGLAHQADE 511-1527: Missing. | ||||||
| Notes: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. | ||||||
| Isoform 3S1 (identifier: O15438-4) The sequence of this isoform differs from the canonical sequence as follows: 1-1242: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1527 | 1527 | Canalicular multispecific organic anion transporter 2 | PRO_0000093360 | |||||
Regions | |||||||||
| Topological domain | 1 – 32 | 32 | Extracellular By similarity | ||||||
| Transmembrane | 33 – 53 | 21 | 1 By similarity | ||||||
| Topological domain | 54 – 73 | 20 | Cytoplasmic By similarity | ||||||
| Transmembrane | 74 – 94 | 21 | 2 By similarity | ||||||
| Topological domain | 95 – 99 | 5 | Extracellular By similarity | ||||||
| Transmembrane | 100 – 120 | 21 | 3 By similarity | ||||||
| Topological domain | 121 – 132 | 12 | Cytoplasmic By similarity | ||||||
| Transmembrane | 133 – 153 | 21 | 4 By similarity | ||||||
| Topological domain | 154 – 171 | 18 | Extracellular By similarity | ||||||
| Transmembrane | 172 – 192 | 21 | 5 By similarity | ||||||
| Topological domain | 193 – 302 | 110 | Cytoplasmic By similarity | ||||||
| Transmembrane | 303 – 323 | 21 | 6 By similarity | ||||||
| Topological domain | 324 – 349 | 26 | Extracellular By similarity | ||||||
| Transmembrane | 350 – 370 | 21 | 7 By similarity | ||||||
| Topological domain | 371 – 426 | 56 | Cytoplasmic By similarity | ||||||
| Transmembrane | 427 – 447 | 21 | 8 By similarity | ||||||
| Topological domain | 448 – 450 | 3 | Extracellular By similarity | ||||||
| Transmembrane | 451 – 471 | 21 | 9 By similarity | ||||||
| Topological domain | 472 – 533 | 62 | Cytoplasmic By similarity | ||||||
| Transmembrane | 534 – 554 | 21 | 10 By similarity | ||||||
| Topological domain | 555 – 576 | 22 | Extracellular By similarity | ||||||
| Transmembrane | 577 – 597 | 21 | 11 By similarity | ||||||
| Topological domain | 598 – 963 | 366 | Cytoplasmic By similarity | ||||||
| Transmembrane | 964 – 984 | 21 | 12 By similarity | ||||||
| Topological domain | 985 – 1021 | 37 | Extracellular By similarity | ||||||
| Transmembrane | 1022 – 1042 | 21 | 13 By similarity | ||||||
| Topological domain | 1043 – 1085 | 43 | Cytoplasmic By similarity | ||||||
| Transmembrane | 1086 – 1106 | 21 | 14 By similarity | ||||||
| Topological domain | 1107 | 1 | Extracellular By similarity | ||||||
| Transmembrane | 1108 – 1128 | 21 | 15 By similarity | ||||||
| Topological domain | 1129 – 1199 | 71 | Cytoplasmic By similarity | ||||||
| Transmembrane | 1200 – 1220 | 21 | 16 By similarity | ||||||
| Topological domain | 1221 – 1222 | 2 | Extracellular By similarity | ||||||
| Transmembrane | 1223 – 1243 | 21 | 17 By similarity | ||||||
| Topological domain | 1244 – 1527 | 284 | Cytoplasmic By similarity | ||||||
| Domain | 311 – 594 | 284 | ABC transmembrane type-1 1 | ||||||
| Domain | 629 – 851 | 223 | ABC transporter 1 | ||||||
| Domain | 971 – 1252 | 282 | ABC transmembrane type-1 2 | ||||||
| Domain | 1291 – 1523 | 233 | ABC transporter 2 | ||||||
| Nucleotide binding | 661 – 668 | 8 | ATP 1 Potential | ||||||
| Nucleotide binding | 1323 – 1330 | 8 | ATP 2 Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 908 | 1 | Phosphoserine By similarity | ||||||
| Glycosylation | 18 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 1006 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 1007 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 1242 | 1242 | Missing in isoform 3S1. | VSP_000043 | |||||
| Alternative sequence | 226 – 510 | 285 | MAIYG…WEPSF → LLNPDPLRGCLPGFTSPQDG HLWLPASPGGEGPLVPKGRG QIPDGGAAAAGGMEEAGKAD GTTQGFSSTWEKCLRRGRGA AGCPAQAPEALLPEGPAGHL RLQLPHQCLLQAYPGPALLH QSTAAQHPDQVYLQPHGPLL VGLPGGWADVPVLHDAVADL TTLLPLHLCDWGEVSYWDHG CHLQEGSGYHQLSQTCVHCG GNCQPHVSGCPALHGPCPLP QSAVVSTPADHPGDLLPLAE PRSLCPGWSRFHGLADSTQR SCGREDARLPGKANEIEGLA HQADE in isoform 3B. | VSP_000040 | |||||
| Alternative sequence | 511 – 1527 | 1017 | Missing in isoform 3B. | VSP_000041 | |||||
| Alternative sequence | 1194 – 1527 | 334 | WLSIG…DAGLA → SEAASLAPCSSRNSQQALWC SGSLSLLSPKQKTGPALPLP HFLLI in isoform 3A. | VSP_000042 | |||||
| Natural variant | 11 | 1 | G → D: dbSNP rs11568609. | VAR_029119 | |||||
| Natural variant | 346 | 1 | S → F: dbSNP rs11568605. | VAR_020235 | |||||
| Natural variant | 607 | 1 | S → N: dbSNP rs45490397. | VAR_020236 | |||||
| Natural variant | 1286 | 1 | R → G: dbSNP rs11568593. | VAR_029120 | |||||
| Natural variant | 1297 | 1 | R → H: dbSNP rs11568591. | VAR_020237 | |||||
| Natural variant | 1348 | 1 | R → C: dbSNP rs45547135. | VAR_020238 | |||||
| Natural variant | 1365 | 1 | Q → R: dbSNP rs11568590. | VAR_020239 | |||||
| Natural variant | 1381 | 1 | R → S: dbSNP rs45461799. | VAR_020240 | |||||
Experimental info | |||||||||
| Sequence conflict | 42 | 1 | C → R in CAA76658. Ref.2 | ||||||
| Sequence conflict | 184 | 1 | A → T in AAD02846. Ref.5 | ||||||
| Sequence conflict | 344 | 1 | A → G in AAC34668. Ref.3 | ||||||
| Sequence conflict | 356 – 361 | 6 | MFLCSM → DVPVAPW Ref.4 | ||||||
| Sequence conflict | 569 | 1 | F → Y in BAA28146. Ref.1 | ||||||
| Sequence conflict | 1128 | 1 | F → C Ref.6 | ||||||
| Sequence conflict | 1212 | 1 | L → I Ref.6 | ||||||
| Sequence conflict | 1249 | 1 | D → E Ref.6 | ||||||
| Sequence conflict | 1335 – 1337 | 3 | CLF → ACS Ref.6 | ||||||
| Sequence conflict | 1359 | 1 | L → F Ref.6 | ||||||
| Sequence conflict | 1362 – 1366 | 5 | LRSQL → VRCQM Ref.6 | ||||||
| Sequence conflict | 1362 | 1 | L → V in AAC34668. Ref.3 | ||||||
| Sequence conflict | 1371 | 1 | Q → R Ref.6 | ||||||
Sequences
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