Reviewed,
UniProtKB/Swiss-Prot O18842 (MT_BALMY)
Last modified
November 25, 2008.
Version 43.
History...
Clusters with 100%,
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Metallothionein Short name=MT |
| Organism | Balaena mysticetus (Bowhead whale) |
| Taxonomic identifier | 27602 [NCBI] |
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Cetacea › Mysticeti › Balaenidae › Balaena |
Protein attributes
| Sequence length | 61 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Metallothioneins have a high content of cysteine residues that bind various heavy metals By similarity. |
| Subunit structure | Monomer By similarity. |
| Domain | Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines. |
| Sequence similarities | Belongs to the metallothionein superfamily. Type 1 family. |
Ontologies
Keywords | |
|---|---|
| Ligand | Metal-binding Metal-thiolate cluster |
| PTM | Acetylation |
Gene Ontology (GO) | |
| Molecular function | metal ion binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 61 | 61 | Metallothionein | PRO_0000197257 | |||||
Regions | |||||||||
| Region | 1 – 29 | 29 | Beta | ||||||
| Region | 30 – 61 | 32 | Alpha | ||||||
Sites | |||||||||
| Metal binding | 5 | 1 | Cluster B By similarity | ||||||
| Metal binding | 7 | 1 | Cluster B By similarity | ||||||
| Metal binding | 13 | 1 | Cluster B By similarity | ||||||
| Metal binding | 15 | 1 | Cluster B By similarity | ||||||
| Metal binding | 19 | 1 | Cluster B By similarity | ||||||
| Metal binding | 21 | 1 | Cluster B By similarity | ||||||
| Metal binding | 24 | 1 | Cluster B By similarity | ||||||
| Metal binding | 26 | 1 | Cluster B By similarity | ||||||
| Metal binding | 29 | 1 | Cluster B By similarity | ||||||
| Metal binding | 33 | 1 | Cluster A By similarity | ||||||
| Metal binding | 34 | 1 | Cluster A By similarity | ||||||
| Metal binding | 36 | 1 | Cluster A By similarity | ||||||
| Metal binding | 37 | 1 | Cluster A By similarity | ||||||
| Metal binding | 41 | 1 | Cluster A By similarity | ||||||
| Metal binding | 44 | 1 | Cluster A By similarity | ||||||
| Metal binding | 48 | 1 | Cluster A By similarity | ||||||
| Metal binding | 50 | 1 | Cluster A By similarity | ||||||
| Metal binding | 57 | 1 | Cluster A By similarity | ||||||
| Metal binding | 59 | 1 | Cluster A By similarity | ||||||
| Metal binding | 60 | 1 | Cluster A By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1 | 1 | N-acetylmethionine By similarity | ||||||
Sequences
References
| [1] | Kaysen J., O'Hara T., Goodwin T., Linnehan R., Hammond T. Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| AF022117 mRNA. Translation: AAB72006.1. | |
3D structure databases | |
| HSSP | HSSP built from PDB template 2MHU based on UniProtKB P02795. |
| SMR | O18842. Positions 1-61. |
| ModBase | Search... |
Phylogenomic databases | |
| HOVERGEN | O18842. |
Family and domain databases | |
| InterPro | IPR002400. GF_cysknot. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. [Graphical view] |
| Gene3D | G3DSA:4.10.10.10. Metallothionein_vert. 1 hit. |
| PANTHER | PTHR23299. Metallothionein_vert. 1 hit. |
| Pfam | PF00131. Metallothio. 1 hit. [Graphical view] |
| PRINTS | PR00438. GFCYSKNOT. PR00860. MTVERTEBRATE. |
| PROSITE | PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MT_BALMY | ||||||||
| Accession | Primary (citable) accession number: O18842 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Metallothioneins Classification of metallothioneins and list of entries |
| SIMILARITY comments Index of protein domains and families |
