Reviewed, UniProtKB/Swiss-Prot O18951 (P2RY2_BOVIN)

Names and origin

Protein names

Recommended name:
    P2Y purinoceptor 2
      Short name(s)=P2Y2

Gene names

Name:

P2RY2

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	133 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
Gene Ontology (GO)
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	‹1 – ›133	›133	P2Y purinoceptor 2
Regions
	Topological domain	‹1 – 26	›26	Cytoplasmic Potential
	Transmembrane	27 – 47	21	4 Potential
	Topological domain	48 – 74	27	Extracellular Potential
	Transmembrane	75 – 95	21	5 Potential
	Topological domain	96 – 116	21	Cytoplasmic Potential
	Transmembrane	117 – ›133	›17	6 Potential
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	133	1

Sequences

	Sequence		Length	Mass (Da)
	O18951-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 301B087C62C75B69	FASTA	133	15,006
	10 20 30 40 50 60 ISVHRCLGVL RPLHSLRWGR ARYARRVAFA VWVLVLYCQA PVLYFVTTST RSSRIICHDT 70 80 90 100 110 120 SARELFSHFV AYSSVMLSLL FAAPFAVILV CYVLMARRLL KPAYGTSGGL PRAKRKSVRT 130 IAIVLTVFVL CFL

References

[1]	"Identification of multiple P2 purinergic receptor subtypes in bovine aortic endothelial cells (BAECs)." Chang A.S., Chang S.M., Schilling W.P. Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF005153 mRNA. Translation: AAB62543.1.
UniGene	Bt.13024
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Phylogenomic databases
HOVERGEN	O18951.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR002286. P2_purnocptor. IPR000356. P2U_purnocptor. [Graphical view]
PANTHER	PTHR19264:SF155. P2U_purnocptor. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00594. P2Y2PRNOCPTR. PR01157. P2YPURNOCPTR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

P2RY2_BOVIN

Accession

Primary (citable) accession number: O18951

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	January 1, 1998
Last modified:	July 22, 2008
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)