Reviewed, UniProtKB/Swiss-Prot O21045 (AI3_DICDI)

Names and origin

Protein names

Recommended name:
    Probable intron-encoded endonuclease aI3
    EC=3.1.-.-
Alternative name(s):
    Cox1/2 intron3 ORF

Gene names

Name:	aI3
ORF Names:	DDB_G0294425

Encoded on

Mitochondrion

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Mitochondrial DNA endonuclease involved in intron homing By similarity.
Subcellular location	MitochondrionBy similarity.
Sequence similarities	Belongs to the LAGLIDADG endonuclease family.

Ontologies

Keywords
Biological process	Intron homing
Cellular component	Mitochondrion
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	intron homing Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro endonuclease activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 232	232	Probable intron-encoded endonuclease aI3		PRO_0000312715

Sequences

	Sequence		Length	Mass (Da)
	O21045-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 50A69E1E4F12147B	FASTA	232	27,932
	10 20 30 40 50 60 MKVEEREYIK KYWVGLMDGV GSIEVNHYRM KNLQYRLVLN VNDSSENMAM LLKIQQVIGG 70 80 90 100 110 120 YLIKRKEKAL IAWTINNKMQ IEDVIKIFED YNLVTVRKRN QLQFLKENLK RNDVNWYLSE 130 140 150 160 170 180 RKNKYKKSLI VSNIEEISYF NEWFSGFVEA TGSFCIRAQK EKYFRIAHRY DMPLLLNLII 190 200 210 220 230 KFNITTKLRE QKNEQYAIEI YKKTLLEVLI THFEKYPLLG DKKNSLETFK TR

References

[1]	"Group-I introns in the cytochrome c oxidase genes of Dictyostelium discoideum: two related ORFs in one loop of a group-I intron, a cox1/2 hybrid gene and an unusually large cox3 gene." Ogawa S., Matsuo K., Angata K., Yanagisawa K., Tanaka Y. Curr. Genet. 31:80-88(1997) [PubMed: 9000384] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: AX3.
[2]	"The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene content and genome organization." Ogawa S., Yoshino R., Angata K., Iwamoto M., Pi M., Kuroe K., Matsuo K., Morio T., Urushihara H., Yanagisawa K., Tanaka Y. Mol. Gen. Genet. 263:514-519(2000) [PubMed: 10821186] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: AX3.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D50297 Genomic DNA. Translation: BAA21126.1. AB000109 Genomic DNA. Translation: BAA78058.1.
PIR	T43754.
RefSeq	NP_050076.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2193942.
Organism-specific databases
dictyBase	DDB_G0294425. ai3.
Family and domain databases
InterPro	IPR001982. Endonuc_LAG/HNH. [Graphical view]
Pfam	PF00961. LAGLIDADG_1. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AI3_DICDI

Accession

Primary (citable) accession number: O21045

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	January 1, 1998
Last modified:	November 25, 2008
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)