Reviewed, UniProtKB/Swiss-Prot O24855 (CYNT_HELPY)

Names and origin

Protein names

Recommended name:
    Carbonic anhydrase
    EC=4.2.1.1
Alternative name(s):
    Carbonate dehydratase

Gene names

Name:	cynT
Ordered Locus Names:	HP_0004

Organism

Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	H(2)CO(3) = CO(2) + H(2)O.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Sequence similarities	Belongs to the beta-class carbonic anhydrase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbon utilization Inferred from electronic annotation. Source: InterPro
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	Carbonic anhydrase		PRO_0000077461
Sites
	Metal binding	38	1	Zinc By similarity
	Metal binding	40	1	Zinc By similarity
	Metal binding	99	1	Zinc By similarity
	Metal binding	102	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	O24855-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 4CE5E051042C012D	FASTA	221	25,515
	10 20 30 40 50 60 MKAFLGALEF QENEYEELKE LYESLKTKQK PHTLFISCVD SRVVPNLITG TKPGELYVIC 70 80 90 100 110 120 NMGNVNPPKT SYKESLSTIA SIEYAIAHVG VQNLIICGHS DCGACGSVHL IHDETTKAKT 130 140 150 160 170 180 PYIANWIQFL EPVKEELKNH PQFSNHFAKR SWLTERLNAR LQLNNLLSYD FIQEKASKNE 190 200 210 220 LKIFGWHYII ETGRIYNYNF ESHFFEPIGE TIKQRKSHEN F

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000511 Genomic DNA. Translation: AAD07077.1.
PIR	D64520.
RefSeq	NP_206806.1.
3D structure databases
HSSP	HSSP built from PDB template 1EKJ based on UniProtKB P17067.
ModBase	Search...
Genome annotation databases
GeneID	898779.
GenomeReviews	Gene locus HP_0004 in contig AE000511_GR.
KEGG	hpy:HP0004.
NMPDR	fig|85962.1.peg.4.
TIGR	HP_0004.
Phylogenomic databases
HOGENOM	O24855.
Family and domain databases
InterPro	IPR001765. Carbonic_anhydrase. IPR015892. Carbonic_anhydrase_CS. [Graphical view]
Gene3D	G3DSA:3.40.1050.10. CO_anhd_prok_pln. 1 hit.
PANTHER	PTHR11002. Carbonic_anhydrase. 1 hit.
Pfam	PF00484. Pro_CA. 1 hit. [Graphical view]
PROSITE	PS00704. PROK_CO2_ANHYDRASE_1. False negative. PS00705. PROK_CO2_ANHYDRASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYNT_HELPY

Accession

Primary (citable) accession number: O24855

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 1, 1998
Last modified:	November 25, 2008
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)