Reviewed, UniProtKB/Swiss-Prot O24933 (HRCA_HELPY)

Names and origin

Protein names

Recommended name:
    Heat-inducible transcription repressor hrcA

Gene names

Name:	hrcA
Ordered Locus Names:	HP_0111

Organism

Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons By similarity.
Sequence similarities	Belongs to the hrcA family.

Ontologies

Keywords
Biological process	Stress response Transcription Transcription regulation
Molecular function	Repressor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	negative regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: HAMAP response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transcription repressor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 266	266	Heat-inducible transcription repressor hrcA HAMAP MF_00081		PRO_0000182483

Sequences

	Sequence		Length	Mass (Da)
	O24933-1 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: F1A3F7001FF41F03	FASTA	266	30,795
	10 20 30 40 50 60 MLRRIKVGSN LNKKESLLDA FVKTYLQILE PISSKRLKEL ADLKISCATI RNYFQILSKE 70 80 90 100 110 120 GMLYQAHSSG ARLPTFKAFE NYWQKSLRFE TLKVNEKRLK SASENFGLFT LLKKPSLERL 130 140 150 160 170 180 ERVIECEKRF LILDFLAFSC ALGYSVKMEK FLLELVGRSV KEVRSIAASF NALSLARQLE 190 200 210 220 230 240 RLEYSNTQIT RFNLMGLKTL LNSPLFFDIL GGKVLERLSK GLHFIEPDCM LVTRPVEFQN 250 260 KRMQLLCVGK LECDYEGFFQ TISEEE

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000511 Genomic DNA. Translation: AAD07182.1. Different initiation.
PIR	G64533.
RefSeq	NP_206911.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	900159.
GenomeReviews	Gene locus HP_0111 in contig AE000511_GR.
KEGG	hpy:HP0111.
NMPDR	fig|85962.1.peg.109.
TIGR	HP_0111.
Phylogenomic databases
HOGENOM	O24933.
Family and domain databases
HAMAP	MF_00081. [Tree]
InterPro	IPR011991. Wing_hlx_DNA_bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HRCA_HELPY

Accession

Primary (citable) accession number: O24933

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	November 4, 2008
This is version 44 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)