Reviewed, UniProtKB/Swiss-Prot O24982 (LNT_HELPY)

Names and origin

Protein names

Recommended name:
    Apolipoprotein N-acyltransferase
      Short name=ALP N-acyltransferase
    EC=2.3.1.-

Gene names

Name:	lnt
Ordered Locus Names:	HP_0180

Organism

Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	425 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Transfers the fatty acyl group on membrane lipoproteins By similarity.
Pathway	Protein modification; lipoprotein biosynthesis (N-acyl transfer).
Subcellular location	Cell inner membrane; Multi-pass membrane proteinBy similarity.
Sequence similarities	Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipoprotein biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	N-acyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 425	425	Apolipoprotein N-acyltransferase
Regions
	Transmembrane	5 – 27	23	Potential
	Transmembrane	37 – 54	18	Potential
	Transmembrane	61 – 78	18	Potential
	Transmembrane	88 – 110	23	Potential
	Transmembrane	117 – 135	19	Potential
	Transmembrane	150 – 167	18	Potential

Sequences

	Sequence		Length	Mass (Da)
	O24982-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 2287520B14B48BBE	FASTA	425	48,474
	10 20 30 40 50 60 MRLLLFNQNA FLLACMFVSS VYVNAVLDAY AIENPYISIT LTSLLAPLSM LAFLKTPRNS 70 80 90 100 110 120 AFALGFFVGA LLFYWCALSF RYSDFTYLLP LIIVLIALVY GVLFYLLLYF ENPYFRLLSF 130 140 150 160 170 180 LGSSFIHPFG FDWLVPDSFF SYSVFRVDKL SLGLVFLACI FLSTKPLKKY RIIGVLLLLG 190 200 210 220 230 240 ALDFNGFKTS DLKKVGNIEL VSTKTPQDLK FDSSYLNDIE NNILKEIKLA QSKQKTLIVF 250 260 270 280 290 300 PETAYPIALE NSPFKAKLED LSDNIAILIG TLRTQGYNLY NSSFLFSKES VQIADKVILA 310 320 330 340 350 360 PFGETMPLPE FLQKPLEKLF FGESTYLYRN APHFSDFTLD DFTFRPLICY EGTSKPAYSN 370 380 390 400 410 420 SPSKIFIVMS NNAWFSPSIE PTLQRTLLKY YARRYDKIIL HSANFSTSYI LSPSLLGDIL FRKRS

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000511 Genomic DNA. Translation: AAD07250.1.
PIR	D64542.
RefSeq	NP_206979.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	900142.
GenomeReviews	Gene locus HP_0180 in contig AE000511_GR.
KEGG	hpy:HP0180.
NMPDR	fig|85962.1.peg.177.
TIGR	HP_0180.
Phylogenomic databases
HOGENOM	O24982.
Family and domain databases
HAMAP	MF_01148. [Tree]
InterPro	IPR004563. Lnt_Trfase. IPR003010. Ntlse/CNhydtse. [Graphical view]
Gene3D	G3DSA:3.60.110.10. Ntlse/CNhydtse. 1 hit.
Pfam	PF00795. CN_hydrolase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00546. lnt. 1 hit.
PROSITE	PS50263. CN_HYDROLASE. False negative. [Graphical view]
ProDom	O24982. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

LNT_HELPY

Accession

Primary (citable) accession number: O24982

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	January 1, 1998
Last modified:	July 22, 2008
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)