Reviewed, UniProtKB/Swiss-Prot O34697 (BCEA_BACSU)

Names and origin

Protein names

Bacitracin export ATP-binding protein bceA

Gene names

Name:	bceA
Synonyms:	barC, ytsC
Ordered Locus Names:	BSU30380

Organism

Bacillus subtilis [Complete proteome] [HAMAP]

Taxonomic identifier

1423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein existence

Evidence at transcript level.

General annotation (Comments)

Function	Part of the ABC transporter complex bceAB (TC 3.A.1.123.5) involved in bacitracin export. Responsible for energy coupling to the transport system.
Subunit structure	The complex is composed of two ATP-binding proteins (bceA) and two transmembrane proteins (bceB) Probable.
Induction	Expression is induced by bacitracin, via the two-component regulatory system bceS/bceR.
Sequence similarities	Belongs to the ABC transporter family. Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Antibiotic resistance Transport
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 253	253	Bacitracin export ATP-binding protein bceA
Regions
	Domain	4 – 243	240	ABC transporter
	Nucleotide binding	40 – 47	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	O34697-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 95D28581A96627AA	FASTA	253	28,234
	10 20 30 40 50 60 MVILEANKIR KSYGNKLNKQ EVLKGIDIHI EKGEFVSIMG ASGSGKTTLL NVLSSIDQVS 70 80 90 100 110 120 HGTIHINGND MTAMKEKQLA EFRKQHLGFI FQDYNLLDTL TVKENILLPL SITKLSKKEA 130 140 150 160 170 180 NRKFEEVAKE LGIYELRDKY PNEISGGQKQ RTSAGRAFIH DPSIIFADEP TGALDSKSAS 190 200 210 220 230 240 DLLNKLSQLN QKRNATIIMV THDPVAASYC GRVIFIKDGQ MYTQLNKGGQ DRQTFFQDIM 250 KTQGVLGGVQ HEH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region." Lapidus A., Galleron N., Sorokin A., Ehrlich S.-D. Microbiology 143:3431-3441(1997) [PubMed: 9387221] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[2]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
[3]	"YtsCD and YwoA, two independent systems that confer bacitracin resistance to Bacillus subtilis." Bernard R., Joseph P., Guiseppi A., Chippaux M., Denizot F. FEMS Microbiol. Lett. 228:93-97(2003) [PubMed: 14612242] [Abstract] Cited for: INDUCTION, PROBABLE FUNCTION. Strain: 168.
[4]	"The BceRS two-component regulatory system induces expression of the bacitracin transporter, BceAB, in Bacillus subtilis." Ohki R., Giyanto X., Tateno K., Masuyama W., Moriya S., Kobayashi K., Ogasawara N. Mol. Microbiol. 49:1135-1144(2003) [PubMed: 12890034] [Abstract] Cited for: INDUCTION, PROBABLE FUNCTION. Strain: 168.
[5]	"Cell wall stress responses in Bacillus subtilis: the regulatory network of the bacitracin stimulon." Mascher T., Margulis N.G., Wang T., Ye R.W., Helmann J.D. Mol. Microbiol. 50:1591-1604(2003) [PubMed: 14651641] [Abstract] Cited for: INDUCTION. Strain: 168 / CU1065.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF008220 Genomic DNA. Translation: AAC00255.1. Z99119 Genomic DNA. Translation: CAB15016.1.
PIR	A70001.
RefSeq	NP_390916.1.
3D structure databases
HSSP	HSSP built from PDB template 1L2T based on UniProtKB Q58206.
ModBase	Search...
Genome annotation databases
GeneID	937246.
GenomeReviews	Gene locus BSU30380 in contig AL009126_GR.
KEGG	bsu:BSU30380.
NMPDR	fig|224308.1.peg.3041.
Organism-specific databases
SubtiList	BG13920. bceA. [Micado]
CMR	Search...
Phylogenomic databases
HOGENOM	O34697.
Enzyme and pathway databases
BioCyc	BSUB224308:BSU3033-MON.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase_core. IPR003439. ABC_transporter-like. [Graphical view]
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
ProDom	PD000006. ABC_transporter. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. False negative. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

BCEA_BACSU

Accession

Primary (citable) accession number: O34697

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 2, 2004
Last sequence update:	January 1, 1998
Last modified:	June 10, 2008
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)