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Reviewed, UniProtKB/Swiss-Prot O34858 (ARLY_BACSU)

Last modified November 25, 2008. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase
Gene names
Name: argH
Ordered Locus Names: BSU29440
OrganismBacillus subtilis [Complete proteome] [HAMAP]
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

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Protein attributes

Sequence length461 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

CytoplasmProbable.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

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Ontologies

Keywords

   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: HAMAP

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 461461Argininosuccinate lyase HAMAP MF_00006
PRO_0000137740

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Sequences

Sequence LengthMass (Da)Tools
O34858-1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 785287FE262AF7D7

FASTA46151,929
        10         20         30         40         50         60 
MKKLWGGRFQ KTPEKWVDEF GASISFDQNL VAEDITGSLA HAAMLKKCGI LTAEEELKIR 

        70         80         90        100        110        120 
EGLNTLLQKA EEGALEFSVD YEDIHLNIEK MLIDEIGPLG GKLHTGRSRN DQVATDMHLY 

       130        140        150        160        170        180 
LKNHVGHIIE LIEAFQSALI EKAEANVETI LPGYTHLQRA QPISFAHHLL AYFWMLERDK 

       190        200        210        220        230        240 
ERFQDSMKRI NKSPLGCGAL AGTTFPIDRD YSAELLGFDA IYENSLDGVS DRDFILEFLS 

       250        260        270        280        290        300 
NSSMLMMHLS RFSEEIILWC SQEFKFIELD DTYATGSSMM PQKKNPDMAE LIRGKTGRVY 

       310        320        330        340        350        360 
GDMMGLFTIM KGLPLAYNKD LQEDKEGMFD TVKTVEGSLQ IFTGMIQTMT VNKDVMKQAT 

       370        380        390        400        410        420 
KQDFSNATEL ADYLAKKGMP FREAHEVVGK LVYTCIERGI YLSDMPFGEF QQASTLFEED 

       430        440        450        460 
IYTVLDPYYA VEKRMSAGGT GFKQVEQALE KAKACVAAGV C

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References

« Hide 'large scale' references
[1]"Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region."
Lapidus A., Galleron N., Sorokin A., Ehrlich S.-D.
Microbiology 143:3431-3441(1997) [PubMed: 9387221] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.

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Cross-references

Sequence databases

AF008220 Genomic DNA. Translation: AAC00321.1.
Z99118 Genomic DNA. Translation: CAB14904.1.
PIRC69589.
RefSeqNP_390822.1.

3D structure databases

HSSPHSSP built from PDB template 1DCN based on UniProtKB P24058.
ModBaseSearch...

Genome annotation databases

GeneID937966.
GenomeReviewsGene locus BSU29440 in contig AL009126_GR.
KEGGbsu:BSU29440.
NMPDRfig|224308.1.peg.2947.

Organism-specific databases

SubtiListBG12571. argH. [Micado]
CMRSearch...

Phylogenomic databases

HOGENOMO34858.

Enzyme and pathway databases

BioCycBSUB224308:BSU2940-MON.

Family and domain databases

HAMAPMF_00006.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
[Graphical view]
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. DCRYSTALLIN.
PR00149. FUMRATELYASE.
TIGRFAMsTIGR00838. argH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameARLY_BACSU
AccessionPrimary (citable) accession number: O34858
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 25, 2008
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents