Lysosome membrane protein 2 - Mus musculus (Mouse)

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Reviewed, UniProtKB/Swiss-Prot O35114 (SCRB2_MOUSE)

Last modified December 16, 2008. Version 59. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Lysosome membrane protein 2
Alternative name(s):
    Lysosome membrane protein II
    LIMP II
    Scavenger receptor class B member 2
    85 kDa lysosomal membrane sialoglycoprotein
    LGP85

Gene names

Name:

Scarb2

Organism

Mus musculus (Mouse)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May act as a lysosomal receptor By similarity.
Subcellular location	Lysosome membrane; Multi-pass membrane protein.
Tissue specificity	Detected in the extracts of brain, heart, lung, liver and kidney.
Post-translational modification	Acylated by palmitic acid group(s) By similarity. Heavily glycosylated.
Sequence similarities	Belongs to the CD36 family.

Ontologies

Keywords
Cellular component	Lysosome Membrane
Domain	Transmembrane
Molecular function	Receptor
PTM	Glycoprotein Lipoprotein Palmitate
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW lysosomal membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GBA	P04062	1	EBI-1564519,EBI-1564609	From a different organism.
Gba	P17439	1	EBI-1564519,EBI-1564504

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

Removed By similarity

Chain

477

Lysosome membrane protein 2

PRO_0000144156

Regions

Topological domain

3

Cytoplasmic Potential

Transmembrane

23

Potential

Topological domain

406

Lumenal Potential

Transmembrane

26

Potential

Topological domain

19

Cytoplasmic Potential

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

O35114-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 55724B77855470DF
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478

54,044

        10         20         30         40         50         60 
MGRCCFYTAG TLSLLLLVTS VTLLVARVFQ KAVDQTIEKN MVLQNGTKVF NSWEKPPLPV 

        70         80         90        100        110        120 
YIQFYFFNVT NPEEILQGEI PLLEEVGPYT YRELRNKANI QFGENGTTIS AVTNKAYVFE 

       130        140        150        160        170        180 
RNQSVGDPNV DLIRTINIPL LTVVDLAQLT LLRELIEAML KAYQQKLFVI HTVHELLWGY 

       190        200        210        220        230        240 
KDEILSLVHI FKPDVSPNFG LFYERNGTND GEYVFLTGED NYLNFSKIVE WNGKTSLDWW 

       250        260        270        280        290        300 
TTDTCNMING TDGDSFHPLI SKDEVLYLFP SDLCRSVHIT FSSFENVEGL PAFRYKVPAE 

       310        320        330        340        350        360 
ILANTSENAG FCIPEGNCMD SGVLNISICK NGAPIIMSFP HFYQADEKFV SAIKGMHPNK 

       370        380        390        400        410        420 
EEHESFVDIN PLTGIILRGA KRFQINTYVR KLDDFVETGD IRTMVFPVMY LNESVLIDKE 

       430        440        450        460        470 
TANQLKSVIN TTLVVTNIPY IIMALGVFFG LVFTWLACRG QGSMDEGTAD ERAPLIRT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a major lysosomal membrane glycoprotein, LGP85/LIMP II in mouse liver." Tabuchi N., Akasaki K., Sasaki T., Kanda N., Tsuji H. J. Biochem. 122:756-763(1997) [PubMed: 9399579] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Tissue: Liver.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Liver and Spinal cord.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
[4]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 276-294 AND 361-378, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
	AB008553 mRNA. Translation: BAA23372.1. AK011123 mRNA. Translation: BAB27416.1. AK083038 mRNA. Translation: BAC38740.1. AK144235 mRNA. Translation: BAE25789.1. BC029073 mRNA. Translation: AAH29073.1.
PIR	JC5670.
RefSeq	NP_031670.1.
UniGene	Mm.297964
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O35114. 4 interactions.
PTM databases
PhosphoSite	O35114.
Proteomic databases
PRIDE	O35114.
Genome annotation databases
Ensembl	ENSMUSG00000029426. Mus musculus. [Contig view]
GeneID	12492.
KEGG	mmu:12492.
Organism-specific databases
MGI	MGI:1196458. Scarb2.
Phylogenomic databases
HOGENOM	O35114.
HOVERGEN	O35114.
Gene expression databases
ArrayExpress	O35114.
CleanEx	MM_SCARB2.
GermOnline	ENSMUSG00000029426. Mus musculus.
Family and domain databases
InterPro	IPR002159. CD36. IPR005429. LimpII. [Graphical view]
PANTHER	PTHR11923. CD36. 1 hit.
Pfam	PF01130. CD36. 1 hit. [Graphical view]
PRINTS	PR01609. CD36FAMILY. PR01611. LIMPII.
ProtoNet	Search...
Other Resources
NextBio	281416.
SOURCE	Search...

Entry information

Entry name

SCRB2_MOUSE

Accession

Primary (citable) accession number: O35114
Secondary accession number(s): Q3UNF8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	January 23, 2007
Last modified:	December 16, 2008
This is version 59 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents