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Reviewed, UniProtKB/Swiss-Prot O35186 (CATK_RAT)

Last modified November 25, 2008. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cathepsin K
    EC=3.4.22.38
Gene names
Name: Ctsk
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation By similarity.

Catalytic activity

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.

Subcellular location

LysosomeBy similarity.

Sequence similarities

Belongs to the peptidase C1 family.

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Ontologies

Keywords

   Cellular componentLysosome
   DomainSignal
   Molecular functionHydrolase
Protease
Thiol protease
   PTMGlycoprotein
Zymogen

Gene Ontology (GO)

   Biological processproteolysis

Inferred from electronic annotation. Source: InterPro

   Cellular componentlysosome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioncysteine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Propeptide16 – 11499Activation peptide
PRO_0000026307
Chain115 – 329215Cathepsin K
PRO_0000026308

Sites

Active site1391 By similarity
Active site2761 By similarity
Active site2961 By similarity

Amino acid modifications

Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation2131N-linked (GlcNAc...) Potential
Disulfide bond136 ↔ 177 By similarity
Disulfide bond170 ↔ 210 By similarity
Disulfide bond269 ↔ 318 By similarity

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Sequences

Sequence LengthMass (Da)Tools
O35186-1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: B416008509CF606A

FASTA32936,791
        10         20         30         40         50         60 
MWVFKFLLLP VVSFALSPEE TLDTQWELWK KTHGKQYNSK VDEISRRLIW EKNLKKISVH 

        70         80         90        100        110        120 
NLEASLGAHT YELAMNHLGD MTSEEVVQKM TGLRVPPSRS FSNDTLYTPE WEGRVPDSID 

       130        140        150        160        170        180 
YRKKGYVTPV KNQGQCGSCW AFSSAGALEG QLKKKTGKLL ALSPQNLVDC VSENYGCGGG 

       190        200        210        220        230        240 
YMTTAFQYVQ QNGGIDSEDA YPYVGQDESC MYNATAKAAK CRGYREIPVG NEKALKRAVA 

       250        260        270        280        290        300 
RVGPVSVSID ASLTSFQFYS RGVYYDENCD RDNVNHAVLV VGYGTQKGNK YWIIKNSWGE 

       310        320 
SWGNKGYVLL ARNKNNACGI TNLASFPKM

« Hide

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References

« Hide 'large scale' references
[1]Payne J.A., Miller L.R.
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Bone.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

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Cross-references

Sequence databases

AF010306 mRNA. Translation: AAB65743.1.
BC078793 mRNA. Translation: AAH78793.1.
RefSeqNP_113748.1.
UniGeneRn.5598

3D structure databases

HSSPHSSP built from PDB template 7PCK based on UniProtKB P43235.
SMRO35186. Positions 20-329.
ModBaseSearch...

Protein family/group databases

MEROPSC01.036.
I29.007.

Genome annotation databases

EnsemblENSRNOG00000021155. Rattus norvegicus. [Contig view]
GeneID29175.
KEGGrno:29175.

Organism-specific databases

RGD61810. Ctsk.

Phylogenomic databases

HOVERGENO35186.

Gene expression databases

ArrayExpressO35186.
GermOnlineENSRNOG00000021155. Rattus norvegicus.

Family and domain databases

InterProIPR000169. Pept_cys_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR015644. Peptidase_C1A_cathepsin-K.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERPTHR12411:SF55. CathpsnK_like. 1 hit.
PTHR12411. Peptidase_C1A. 1 hit.
PfamPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSPR00705. PAPAIN.
ProDomPD000158. Peptidase_C1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio608248.

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Entry information

Entry nameCATK_RAT
AccessionPrimary (citable) accession number: O35186
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 1, 1998
Last modified: November 25, 2008
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents