Reviewed, UniProtKB/Swiss-Prot O35658 (C1QBP_MOUSE)

Names and origin

Protein names

Recommended name:
    Complement component 1 Q subcomponent-binding protein, mitochondrial
Alternative name(s):
    Glycoprotein gC1qBP
      Short name=C1qBP
    GC1q-R protein

Gene names

Name:	C1qbp
Synonyms:	Gc1qbp

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Not known. Binds to the globular "heads" of C1Q thus inhibiting C1 activation.
Subcellular location	Mitochondrion matrixPotential.
Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the MAM33 family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
PTM	Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Prkcz	Q02956	2	EBI-642072,EBI-642057

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 70	70	Mitochondrion By similarity
	Chain	71 – 278	208	Complement component 1 Q subcomponent-binding protein, mitochondrial		PRO_0000018591
Amino acid modifications
	Modified residue	184	1	Phosphotyrosine By similarity
	Modified residue	197	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O35658-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 7B438DD6EF88FFF0	FASTA	278	31,013
	10 20 30 40 50 60 MLPLLRCVPR SLGAASGLRT AIPAQPLRHL LQPAPRPCLR PFGLLSVRAG SARRSGLLQP 70 80 90 100 110 120 PVPCACGCGA LHTEGDKAFV EFLTDEIKEE KKIQKHKSLP KMSGDWELEV NGTEAKLLRK 130 140 150 160 170 180 VAGEKITVTF NINNSIPPTF DGEEEPSQGQ KAEEQEPERT STPNFVVEVT KTDGKKTLVL 190 200 210 220 230 240 DCHYPEDEIG HEDEAESDIF SIKEVSFQAT GDSEWRDTNY TLNTDSLDWA LYDHLMDFLA 250 260 270 DRGVDNTFAD ELVELSTALE HQEYITFLED LKSFVKNQ

References

[1]	"Characterisation of the rat and mouse homologues of gC1qBP, a 33 kDa glycoprotein that binds to the globular 'heads' of C1q." Lynch N.J., Reid K.B., van den Berg R.H., Daha M.R., Leigh L.A., Ghebrehiwet B., Lim W.B., Schwaeble W.J. FEBS Lett. 418:111-114(1997) [PubMed: 9414106] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6 X CBA.
[2]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 78-91 AND 102-119, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ001101 mRNA. Translation: CAA04530.1.
UniGene	Mm.30049
3D structure databases
HSSP	HSSP built from PDB template 1P32 based on UniProtKB Q07021.
ModBase	Search...
Protein-protein interaction databases
IntAct	O35658. 2 interactions.
PTM databases
PhosphoSite	O35658.
Proteomic databases
PRIDE	O35658.
Genome annotation databases
Ensembl	ENSMUSG00000018446. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:1194505. C1qbp.
Phylogenomic databases
HOVERGEN	O35658.
Gene expression databases
ArrayExpress	O35658.
GermOnline	ENSMUSG00000018446. Mus musculus.
Family and domain databases
InterPro	IPR003428. MAM33. [Graphical view]
Gene3D	G3DSA:3.10.280.10. MAM33. 1 hit.
Pfam	PF02330. MAM33. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

C1QBP_MOUSE

Accession

Primary (citable) accession number: O35658

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	December 16, 2008
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)