Reviewed, UniProtKB/Swiss-Prot O35945 (AL1A7_MOUSE)

Names and origin

Protein names

Recommended name:
    Aldehyde dehydrogenase, cytosolic 1
    EC=1.2.1.3
Alternative name(s):
    ALDH class 1
    ALHDII
    ALDH-E1
    Aldehyde dehydrogenase family 1 member A7
    Aldehyde dehydrogenase phenobarbital-inducible

Gene names

Name:	Aldh1a7
Synonyms:	Aldh-pb

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Can oxidize benzaldehyde, propionaldehyde and acetaldehyde By similarity. No detectable activity with retinal.
Catalytic activity	An aldehyde + NAD(+) + H(2)O = an acid + NADH.
Pathway	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Subunit structure	Homotetramer By similarity. UniProtKB P13601
Subcellular location	CytoplasmBy similarity. UniProtKB P13601
Tissue specificity	Highest level in liver, high level in lung, low level in kidney and testis. Ref.1
Miscellaneous	Xenopus embryos injected with Aldh1a7 mRNA failed to produce retinoic acid in contrast to embryos injected with Aldh1a1.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW retinal metabolic process Inferred from direct assay. Source: MGI
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity UniProtKB P00352
	Chain	2 – 501	500	Aldehyde dehydrogenase, cytosolic 1 UniProtKB P00352		PRO_0000291264
Regions
	Nucleotide binding	246 – 251	6	NAD By similarity UniProtKB Q28399
Sites
	Active site	269	1	Proton acceptor By similarity UniProtKB P51977
	Active site	303	1	Nucleophile By similarity UniProtKB P51977
	Site	170	1	Transition state stabilizer By similarity UniProtKB P51977

Sequences

	Sequence		Length	Mass (Da)
	O35945-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 42DE97962799237B	FASTA	501	54,588
	10 20 30 40 50 60 MSSPAQPAVP APLANLKIQH TKIFINNEWH DSVSSKKFPV LNPATEEVIC HVEEGDKADV 70 80 90 100 110 120 DKAVKAARQA FQIGSPWRTM DASERGRLLN KLADLMERDR LLLATMESMN AGKVFAHAYL 130 140 150 160 170 180 LDVEISIKAL QYFAGWADKI HGQTIPSDGN IFTYTRREPI GVCGQIIPWN GPLIIFTWKL 190 200 210 220 230 240 GPALSCGNTV VVKPAEQTPL TALHMASLIK EAGFPPGVVN IVPGYGPTAG GAISSHMDID 250 260 270 280 290 300 KVSFTGSTEV GKLIKEAAGK SNLKRVTLEL GGKSPCIVFA DADLDSAVEF AHQGVFFHQG 310 320 330 340 350 360 QICVAASRLF VEESIYDEFV RRSVERAKKY ILGNPLNSGI NQGPQIDKEQ HNKILGLIES 370 380 390 400 410 420 GKKEGAKLEC GGGRWGNKGF FVQPTVFSNV TDEMRIAKEE IFGPVQQIMK FKSMDDVIKR 430 440 450 460 470 480 ANNTTYGLAA GVFTKDLDKA ITVSSALQAG MVWVNCYLAV PVQCPFGGFK MSGNGRELGE 490 500 HGLYEYTELK TVAMQISQKN S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular analysis of two closely related mouse aldehyde dehydrogenase genes: identification of a role for Aldh1, but not Aldh-pb, in the biosynthesis of retinoic acid." Hsu L.C., Chang W.C., Hoffmann I., Duester G. Biochem. J. 339:387-395(1999) [PubMed: 10191271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Strain: C57BL/6. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Olfactory epithelium.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U96401 mRNA. Translation: AAB64411.1. BC046315 mRNA. Translation: AAH46315.2.
RefSeq	NP_036051.1.
UniGene	Mm.14609
3D structure databases
HSSP	HSSP built from PDB template 1BXS based on UniProtKB P51977.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000024747. Mus musculus. [Contig view]
GeneID	26358.
KEGG	mmu:26358.
NMPDR	fig|10090.3.peg.4833.
Organism-specific databases
MGI	MGI:1347050. Aldh1a7.
Phylogenomic databases
HOGENOM	O35945.
HOVERGEN	O35945.
Gene expression databases
ArrayExpress	O35945.
CleanEx	MM_ALDH1A7.
Family and domain databases
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	304207.
SOURCE	Search...

Entry information

Entry name

AL1A7_MOUSE

Accession

Primary (citable) accession number: O35945
Secondary accession number(s): Q80ZX7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	January 1, 1998
Last modified:	November 25, 2008
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)