Reviewed, UniProtKB/Swiss-Prot O42506 (HXA9A_FUGRU)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A9a
      Short name=HoxA-9

Gene names

Name:	hoxa9a
Synonyms:	hoxa9

Organism

Fugu rubripes (Japanese pufferfish) (Takifugu rubripes)

Taxonomic identifier

31033 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Tetraodontiformes › Tetradontoidea › Tetraodontidae › Takifugu

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription activator activity Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	Homeobox protein Hox-A9a		PRO_0000200086
Regions
	DNA binding	216 – 275	60	Homeobox

Sequences

	Sequence		Length	Mass (Da)
	O42506-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: FDD3D052702BE36C	FASTA	283	31,410
	10 20 30 40 50 60 MSTSGTLTSY YVDSLILPEN EELSVPRYSA GPGHQHSRQP ASIGDPHSEL GTCSFPSKPP 70 80 90 100 110 120 VFGPSWSHVP AQFPGTVSSV YHHHYGHHQG PVGTETDGRY QSWLLEPMSG SLPMAGLPTT 130 140 150 160 170 180 HHYGIKPDGL GVRSGGALPG SHTALLLSDY ANGTVATAPP VEKDAVSSHT GDGVDTEEKP 190 200 210 220 230 240 GLDPSKSAVY ITFYLYRTYS GDRDNPVSNW LHASATRKKR CPYTKHQILE LEKEFLFNTY 250 260 270 280 LTRDRRYEVA RLLNLTERQV KIWFQNRRMK MKKFNKDGAP KDD

References

[1]	"Organization of the Fugu rubripes Hox clusters: evidence for continuing evolution of vertebrate Hox complexes." Aparicio S.J., Hawker K., Cottage A., Mikawa Y., Zuo L., Venkatesh B., Chen E., Krumlauf R., Brenner S. Nat. Genet. 16:79-83(1997) [PubMed: 9140399] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters." Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B. Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006) [PubMed: 16636282] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U92573 Genomic DNA. Translation: AAB68684.1. DQ481663 Genomic DNA. Translation: ABF22379.1.
3D structure databases
HSSP	HSSP built from PDB template 9ANT based on UniProtKB P02833.
SMR	O42506. Positions 204-279.
ModBase	Search...
Genome annotation databases
Ensembl	NEWSINFRUG00000149637. Fugu rubripes. [Contig view]
Phylogenomic databases
HOVERGEN	O42506.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017112. Homeobox_Hox9. IPR012287. Homeodomain-rel. IPR006711. Hox9_act. IPR000047. HTH_lambrepressr. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. PF04617. Hox9_act. 1 hit. [Graphical view]
PIRSF	PIRSF037109. Homeobox_Hox9. 1 hit.
PRINTS	PR00024. HOMEOBOX. PR00031. HTHREPRESSR.
ProDom	PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA9A_FUGRU

Accession

Primary (citable) accession number: O42506
Secondary accession number(s): Q1KL15

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 1, 1998
Last modified:	November 25, 2008
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)