Reviewed, UniProtKB/Swiss-Prot O42779 (CARP9_CANAL)

Names and origin

Protein names

Recommended name:
    Candidapepsin-9
    EC=3.4.23.24
Alternative name(s):
    Aspartate protease 9
    ACP 9
    Secreted aspartic protease 9

Gene names

Name:

SAP9

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	544 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.
Subcellular location	Secreted.
Post-translational modification	O-glycosylated By similarity.
Sequence similarities	Belongs to the peptidase A1 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Aspartyl protease Hydrolase Protease
PTM	Glycoprotein Zymogen
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Propeptide	18 – ?		Activation peptide Potential
	Chain	? – 544		Candidapepsin-9
Sites
	Active site	167	1	By similarity
	Active site	371	1	By similarity
Amino acid modifications
	Glycosylation	212	1	N-linked (GlcNAc...) Potential
	Glycosylation	240	1	N-linked (GlcNAc...) Potential
	Glycosylation	252	1	N-linked (GlcNAc...) Potential
	Glycosylation	422	1	N-linked (GlcNAc...) Potential
	Glycosylation	499	1	N-linked (GlcNAc...) Potential
	Disulfide bond	406 ↔ 441		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O42779-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: E6D755A46040A486	FASTA	544	58,625
	10 20 30 40 50 60 MRLNSVALLS LVATALAAKA PFKIDFEVRR GESKDDLSPE DDSNPRFVKR DGSLDMTLTN 70 80 90 100 110 120 KQTFYMATLK IGSNEDENRV LEDTGSSDLW VMSHDLKCVS APISKRNERS FGHGTGVKLN 130 140 150 160 170 180 ERELMQKRKN LYQPSRTIET DEEKEASEKI HNKLFGFGSI YSTVYITEGP GAYSTFSPLV 190 200 210 220 230 240 GTEGGSGGSG GSNTCRSYGS FNTENSDTFK KNNTNDFEIQ YADDTSAIGI WGYDDVTISN 250 260 270 280 290 300 VTVKDLSFAI ANETSSDVGV LGIGLPGLEV TTQLRYTYQN LPLKLKADGI IAKSLYSLYL 310 320 330 340 350 360 NTADAKAGSI LFGAIDHAKY QGDLVTVKMM RTYSQISYPV RIQVPVLKID VESSSGSTTN 370 380 390 400 410 420 ILSGTTGVVL DTGSTLSYVF SDTLQSLGKA LNGQYSNSVG AYVVNCNLAD SSRTVDIEFG 430 440 450 460 470 480 GNKTIKVPIS DLVLQASKST CILGVMQQSS SSSYMLFGDN ILRSAYIVYD LDDYEVSLAQ 490 500 510 520 530 540 VSYTNKESIE VIGASGITNS SGSGTTSSSG TSTSTSTRHS AGSIISNPVY GLLLSLLISY YVLV

References

[1]	"Differential regulation of SAP8 and SAP9, which encode two new members of the secreted aspartic proteinase family in Candida albicans." Monod M., Hube B., Hess D., Sanglard D. Microbiology 144:2731-2737(1998) [PubMed: 9802014] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C74.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF043331 Genomic DNA. Translation: AAC69996.1.
3D structure databases
HSSP	HSSP built from PDB template 1EAG based on UniProtKB P28871.
ModBase	Search...
Protein family/group databases
MEROPS	A01.067.
Family and domain databases
InterPro	IPR001969. Pept_Asp_AS. IPR009007. Pept_Aspartc_cat. IPR001461. Peptidase_A1. [Graphical view]
Gene3D	G3DSA:2.40.70.10. Pept_Aspartc_cat. 2 hits.
PANTHER	PTHR13683. Peptidase_A1. 1 hit.
Pfam	PF00026. Asp. 1 hit. [Graphical view]
PRINTS	PR00792. PEPSIN.
PROSITE	PS00141. ASP_PROTEASE. 1 hit. [Graphical view]
ProDom	O42779. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

CARP9_CANAL

Accession

Primary (citable) accession number: O42779

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	June 1, 1998
Last modified:	July 22, 2008
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)