Alpha-glucuronidase precursor - Aspergillus tubingensis

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Reviewed, UniProtKB/Swiss-Prot O42814 (AGUA_ASPTU)

Last modified November 25, 2008. Version 40. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Alpha-glucuronidase
    EC=3.2.1.139
Alternative name(s):
    Alpha-glucosiduronase

Gene names

Name:

aguA

Organism

Aspergillus tubingensis

Taxonomic identifier

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	841 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Releases 4-O-methylglucuronic acid from xylan.
Catalytic activity	An alpha-D-glucuronoside + H(2)O = an alcohol + D-glucuronate.
Subcellular location	Secreted.
Sequence similarities	Belongs to the glycosyl hydrolase 67 family.
Biophysicochemical properties	pH dependence: Optimum pH is 4.5-6.0. Temperature dependence: Optimum temperature is 70 degrees Celsius.

Ontologies

Keywords
Biological process	Xylan degradation
Cellular component	Secreted
Domain	Signal
Molecular function	Glycosidase Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	xylan catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: InterPro
Molecular function	alpha-glucuronidase activity Inferred from electronic annotation. Source: InterPro cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

20

Potential

Chain

821

Alpha-glucuronidase

PRO_0000012243

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

O42814-1 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 68F17219D1988309
Show »

841

93,904

        10         20         30         40         50         60 
MRGSNLFQLT LALLLSLVAA EDGYNGWLRY APVSCDLHCR QALPSHIVLL NSTKGSPIET 

        70         80         90        100        110        120 
AGRELKAGFQ SILSTNLTFH PFQCDSSASI LVATLDEYRQ KCRDINLPEL DPDGFWLQSE 

       130        140        150        160        170        180 
GDTVRILGNN ARGALYGAYE YLAMVAQRNF SRVAYTTNPH APIRWVNQWD NMDGSIERGY 

       190        200        210        220        230        240 
GGASIFFKDG TVVEDMAPVE QYARLLASIR INAIVVNNVN ANATLLLPEN MKGLGRIADA 

       250        260        270        280        290        300 
CRPYGVQIGI SLNFASPESL GGLETYDPLD PGVIAWWQNI TDSLYTYVPD MAGYLVKADS 

       310        320        330        340        350        360 
EGQPGPDTYN RTLSQGANLF ARALQPHGGV LMYRAFVYND NLNESDWKAD RAKAAVEYFK 

       370        380        390        400        410        420 
DLDGQFYENV VVQIKYGPID FQVREPTSPL FANLYQTNTA IELEVSQEYL GQQCHLVYLP 

       430        440        450        460        470        480 
PLWKTVLDFD LRVDHKPSMV RDILSGQRFN RTLGGWAAVV NVGTNRTWLG SHLAMSNLYA 

       490        500        510        520        530        540 
YGRLAWSPTD DSEQILKDWT RLTFGQNRQV IDTIADMPMT SWPAYENYTG NLGIQTLTDI 

       550        560        570        580        590        600 
LYTHYGPNPA TQDNNGWGQW TRADHNSVGM DRTISNGTGY TGQYPEEVAR LYESLETTPD 

       610        620        630        640        650        660 
DLVLWFHHVP WTHRLHSGLT VIQHFYNAHY AGSEAAHGFI RQWESLKGLI DRERYEAMRS 

       670        680        690        700        710        720 
RLVYQAGHSI VWRDAINNFY YNMTGIPDVA GRVGHHPWRI EAESMRLDGY QTYTVSPFEA 

       730        740        750        760        770        780 
ASNTTAIITT SNSTTGTART TIKAPSGVYD IGVNYYDLYG GQSKWTLSVG DKVVGQWLGD 

       790        800        810        820        830        840 
MEHQSLGHTP SIYLDGHSAT RITFHGVVVR QGDQLKIVGE ANGVEPAPVD YVVLLPPGVV 


D

References

[1]

"AguA, the gene encoding an extracellular alpha-glucuronidase from Aspergillus tubingensis, is specifically induced on xylose and not on glucuronic acid."
de Vries R.P., Poulsen C.H., Madrid S., Visser J.
J. Bacteriol. 180:243-249(1998) [PubMed: 9440512] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: NW756.

Cross-references

Sequence databases
	Y15405 Genomic DNA. Translation: CAA75605.1.
3D structure databases
HSSP	HSSP built from PDB template 1K9D based on UniProtKB Q8VVD2.
ModBase	Search...
Family and domain databases
InterPro	IPR011395. Alpha-glucuronds. IPR005154. Glyco_hydro_67. IPR011099. Glyco_hydro_67_C. IPR011100. Glyco_hydro_67_M. IPR013781. Glyco_hydro_sub_cat. [Graphical view]
Gene3D	G3DSA:3.90.1330.10. Glyco_hydro_67_C. 1 hit. G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
Pfam	PF07477. Glyco_hydro_67C. 1 hit. PF07488. Glyco_hydro_67M. 1 hit. PF03648. Glyco_hydro_67N. 1 hit. [Graphical view]
PIRSF	PIRSF029900. Alpha-glucuronds. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AGUA_ASPTU

Accession

Primary (citable) accession number: O42814

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	June 1, 1998
Last modified:	November 25, 2008
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents