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Reviewed, UniProtKB/Swiss-Prot O43306 (ADCY6_HUMAN)

Last modified December 16, 2008. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Adenylate cyclase type 6
    EC=4.6.1.1
Alternative name(s):
    Adenylate cyclase type VI
    ATP pyrophosphate-lyase 6
    Adenylyl cyclase 6
    Ca(2+)-inhibitable adenylyl cyclase
Gene names
Name: ADCY6
Synonyms: KIAA0422
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length1168 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Membrane-bound, calcium-inhibitable adenylyl cyclase By similarity.

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactor

Binds 2 magnesium ions per subunit By similarity.

Enzyme regulation

Inhibition by calcium in the submicromolar concentration range By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 2 guanylate cyclase domains.

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Ontologies

Keywords

   Biological processcAMP biosynthesis
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Transmembrane
   LigandMagnesium
Metal-binding
   Molecular functionLyase
   PTMGlycoprotein
Phosphoprotein

Gene Ontology (GO)

   Biological processcAMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

intracellular signaling cascade

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenylate cyclase activity

Inferred from electronic annotation. Source: InterPro

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O43306-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O43306-2)

The sequence of this isoform differs from the canonical sequence as follows:
     762-814: Missing.
Notes: No experimental confirmation available.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11681168Adenylate cyclase type 6
PRO_0000195699

Regions

Topological domain1 – 151151Cytoplasmic Potential
Transmembrane152 – 16817 Potential
Transmembrane181 – 19717 Potential
Transmembrane214 – 23017 Potential
Transmembrane239 – 25517 Potential
Transmembrane259 – 27517 Potential
Transmembrane289 – 30517 Potential
Topological domain306 – 673368Cytoplasmic Potential
Transmembrane674 – 69118 Potential
Transmembrane702 – 71817 Potential
Transmembrane743 – 75917 Potential
Topological domain760 – 81960Extracellular Potential
Transmembrane820 – 83617 Potential
Transmembrane839 – 85517 Potential
Transmembrane897 – 91317 Potential
Topological domain914 – 1168255Cytoplasmic Potential

Sites

Metal binding3841Magnesium 1 By similarity
Metal binding3841Magnesium 2 By similarity
Metal binding3851Magnesium 2; via carbonyl oxygen By similarity
Metal binding4281Magnesium 1 By similarity
Metal binding4281Magnesium 2 By similarity

Amino acid modifications

Modified residue541Phosphoserine Ref.5 Ref.6
Modified residue5761Phosphoserine Ref.6 Ref.7
Glycosylation7931N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence762 – 81453Missing in isoform 2.
VSP_000244
Natural variant6741A → S: dbSNP rs3730071.
VAR_048249

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 11, 2001. Version 2.
Checksum: 127BB6E67F73AA61

FASTA1,168130,615
        10         20         30         40         50         60 
MSWFSGLLVP KVDERKTAWG ERNGQKRSRR RGTRAGGFCT PRYMSCLRDA EPPSPTPAGP 

        70         80         90        100        110        120 
PRCPWQDDAF IRRGGPGKGK ELGLRAVALG FEDTEVTTTA GGTAEVAPDA VPRSGRSCWR 

       130        140        150        160        170        180 
RLVQVFQSKQ FRSAKLERLY QRYFFQMNQS SLTLLMAVLV LLTAVLLAFH AAPARPQPAY 

       190        200        210        220        230        240 
VALLACAAAL FVGLMVVCNR HSFRQDSMWV VSYVVLGILA AVQVGGALAA DPRSPSAGLW 

       250        260        270        280        290        300 
CPVFFVYIAY TLLPIRMRAA VLSGLGLSTL HLILAWQLNR GDAFLWKQLG ANVLLFLCTN 

       310        320        330        340        350        360 
VIGICTHYPA EVSQRQAFQE TRGYIQARLH LQHENRQQER LLLSVLPQHV AMEMKEDINT 

       370        380        390        400        410        420 
KKEDMMFHKI YIQKHDNVSI LFADIEGFTS LASQCTAQEL VMTLNELFAR FDKLAAENHC 

       430        440        450        460        470        480 
LRIKILGDCY YCVSGLPEAR ADHAHCCVEM GVDMIEAISL VREVTGVNVN MRVGIHSGRV 

       490        500        510        520        530        540 
HCGVLGLRKW QFDVWSNDVT LANHMEAGGR AGRIHITRAT LQYLNGDYEV EPGRGGERNA 

       550        560        570        580        590        600 
YLKEQHIETF LILGASQKRK EEKAMLAKLQ RTRANSMEGL MPRWVPDRAF SRTKDSKAFR 

       610        620        630        640        650        660 
QMGIDDSSKD NRGTQDALNP EDEVDEFLSR AIDARSIDQL RKDHVRRFLL TFQREDLEKK 

       670        680        690        700        710        720 
YSRKVDPRFG AYVACALLVF CFICFIQLLI FPHSTLMLGI YASIFLLLLI TVLICAVYSC 

       730        740        750        760        770        780 
GSLFPKALQR LSRSIVRSRA HSTAVGIFSV LLVFTSAIAN MFTCNHTPIR SCAARMLNLT 

       790        800        810        820        830        840 
PADITACHLQ QLNYSLGLDA PLCEGTMPTC SFPEYFIGNM LLSLLASSVF LHISSIGKLA 

       850        860        870        880        890        900 
MIFVLGLIYL VLLLLGPPAT IFDNYDLLLG VHGLASSNET FDGLDCPAAG RVALKYMTPV 

       910        920        930        940        950        960 
ILLVFALALY LHAQQVESTA RLDFLWKLQA TGEKEEMEEL QAYNRRLLHN ILPKDVAAHF 

       970        980        990       1000       1010       1020 
LARERRNDEL YYQSCECVAV MFASIANFSE FYVELEANNE GVECLRLLNE IIADFDEIIS 

      1030       1040       1050       1060       1070       1080 
EERFRQLEKI KTIGSTYMAA SGLNASTYDQ VGRSHITALA DYAMRLMEQM KHINEHSFNN 

      1090       1100       1110       1120       1130       1140 
FQMKIGLNMG PVVAGVIGAR KPQYDIWGNT VNVSSRMDST GVPDRIQVTT DLYQVLAAKG 

      1150       1160 
YQLECRGVVK VKGKGEMTTY FLNGGPSS

« Hide

Isoform 2.

Checksum: D1D26C1E15FAC0B0
Show »

1,115124,865

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References

« Hide 'large scale' references
[1]"Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues."
Wicker R., Catalan A.G., Cailleux A.-F., Starenki D., Stengel D., Sarasin A., Suarez H.G.
Biochim. Biophys. Acta 1493:279-283(2000) [PubMed: 10978539] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Thyroid.
[2]"Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 4:307-313(1997) [PubMed: 9455477] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[3]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract]
Cited for: SEQUENCE REVISION.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Eye.
[5]"Large-scale characterization of HeLa cell nuclear phosphoproteins."
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-54, MASS SPECTROMETRY.
Tissue: Epithelium.
[6]"Phosphoproteome of resting human platelets."
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A.
J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-54 AND SER-576, MASS SPECTROMETRY.
Tissue: Platelet.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-576, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF250226 mRNA. Translation: AAF82478.1.
AB007882 mRNA. Translation: BAA24852.2. Different initiation.
BC064923 mRNA. Translation: AAH64923.1.
RefSeqNP_056085.1.
NP_066193.1.
UniGeneHs.525401
Hs.694408

3D structure databases

HSSPHSSP built from PDB template 1AZS based on UniProtKB P30803.
SMRO43306. Positions 364-553.
ModBaseSearch...

Protein-protein interaction databases

IntActO43306. 1 interaction.

PTM databases

PhosphoSiteO43306.

Proteomic databases

PRIDEO43306.

Genome annotation databases

EnsemblENSG00000174233. Homo sapiens. [Contig view]
GeneID112.
KEGGhsa:112.

Organism-specific databases

GeneCardsGC12M047446.
H-InvDBHIX0010771.
HGNCHGNC:237. ADCY6.
HPACAB018365.
MIM600294. gene.
PharmGKBPA27.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

HOGENOMO43306.
HOVERGENO43306.

Gene expression databases

ArrayExpressO43306.
CleanExHS_ADCY6.
GermOnlineENSG00000174233. Homo sapiens.

Family and domain databases

InterProIPR001054. A/G_cyclase.
IPR009398. Aden_cycl_like.
[Graphical view]
Gene3DG3DSA:3.30.70.1230. A/G_cyclase. 2 hits.
PfamPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTSM00044. CYCc. 2 hits.
[Graphical view]
PROSITEPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio431.
SOURCESearch...

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Entry information

Entry nameADCY6_HUMAN
AccessionPrimary (citable) accession number: O43306
Secondary accession number(s): Q9NR75
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 11, 2001
Last modified: December 16, 2008
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents