Reviewed, UniProtKB/Swiss-Prot O43423 (AN32C_HUMAN)

Names and origin

Protein names

Recommended name:
    Acidic leucine-rich nuclear phosphoprotein 32 family member C
Alternative name(s):
    Phosphoprotein 32-related protein 1
    Tumorigenic protein pp32r1

Gene names

Name:	ANP32C
Synonyms:	PP32R1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	234 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Tissue specificity	Expressed in activated stem cells, such as mobilized CD34+ cells and cord blood CD34+ cells, but not in resting bone marrow CD34+ cells. Expressed in a variety of neoplastic cell lines, mainly in prostatic adenocarcinoma cell lines. Not expressed in normal protastic tissue. Ref.1 Ref.3
Sequence similarities	Belongs to the ANP32 family. Contains 4 LRR (leucine-rich) repeats.
Caution	The His-140 polymorphism is uncertain. It has been found in prostatic cell line without corresponding normal tissue sample. Cells transfected with this variant expressed at least twice as much proteins than native cells.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Leucine-rich repeat Repeat
Gene Ontology (GO)
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 234	234	Acidic leucine-rich nuclear phosphoprotein 32 family member C		PRO_0000137597
Regions
	Repeat	44 – 63	20	LRR 1
	Repeat	64 – 84	21	LRR 2
	Repeat	85 – 107	23	LRR 3
	Repeat	111 – 134	24	LRR 4
	Compositional bias	157 – 228	72	Asp/Glu-rich (highly acidic)
Natural variations
	Natural variant	23	1	A → V Ref.3		VAR_026702
	Natural variant	71	1	R → K: dbSNP rs2288675. Ref.3		VAR_020419
	Natural variant	105	1	L → P: dbSNP rs17008716.		VAR_048314
	Natural variant	140	1	Y → H Ref.3		VAR_026703
	Natural variant	204	1	E → G: dbSNP rs2288676.		VAR_020420

Sequences

	Sequence		Length	Mass (Da)
	O43423-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 2515D9678EACC5C2	FASTA	234	26,762
	10 20 30 40 50 60 MEMGRRIHSE LRNRAPSDVK ELALDNSRSN EGKLEALTDE FEELEFLSKI NGGLTSISDL 70 80 90 100 110 120 PKLKLRKLEL RVSGGLEVLA EKCPNLTHLY LSGNKIKDLS TIEPLKQLEN LKSLDLFNCE 130 140 150 160 170 180 VTNLNDYGEN VFKLLLQLTY LDSCYWDHKE APYSDIEDHV EGLDDEEEGE HEEEYDEDAQ 190 200 210 220 230 VVEDEEGEEE EEEGEEEDVS GGDEEDEEGY NDGEVDGEED EEELGEEERG QKRK

References

[1]	"Modulation of oncogenic potential by alternative gene use in human prostate cancer." Kadkol S.S., Brody J.R., Pevsner J., Bai J., Pasternack G.R. Nat. Med. 5:275-279(1999) [PubMed: 10086381] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[2]	Erratum Kadkol S.S., Brody J.R., Pevsner J., Bai J., Pasternack G.R. Nat. Med. 5:1087-1087(1999) [PubMed: 10471270] [Abstract]
[3]	"Identification of a functional mutation in pp32r1 (ANP32C)." Kochevar G.J., Brody J.R., Kadkol S.S., Murphy K.M., Pasternack G.R. Hum. Mutat. 23:546-551(2004) [PubMed: 15146458] [Abstract] Cited for: VARIANTS VAL-23; LYS-71 AND HIS-140, TISSUE SPECIFICITY.
[4]	"The Anp32 family of proteins containing leucine-rich repeats." Matilla A., Radrizzani M. Cerebellum 4:7-18(2005) [PubMed: 15895553] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF008216 Genomic DNA. Translation: AAD12746.1.
RefSeq	NP_036535.1.
UniGene	Hs.661161
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	O43423.
Genome annotation databases
Ensembl	ENSG00000184701. Homo sapiens. [Contig view]
GeneID	23520.
KEGG	hsa:23520.
Organism-specific databases
GeneCards	GC04M165337.
H-InvDB	HIX0031531.
HGNC	HGNC:16675. ANP32C.
MIM	606877. gene.
PharmGKB	PA24813.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O43423.
HOVERGEN	O43423.
Gene expression databases
ArrayExpress	O43423.
CleanEx	HS_ANP32C.
GermOnline	ENSG00000184701. Homo sapiens.
Family and domain databases
InterPro	IPR001611. LRR. [Graphical view]
Pfam	PF00560. LRR_1. 1 hit. [Graphical view]
PRINTS	PR00019. LEURICHRPT.
ProtoNet	Search...
Other Resources
LinkHub	O43423.
NextBio	45969.
SOURCE	Search...

Entry information

Entry name

AN32C_HUMAN

Accession

Primary (citable) accession number: O43423

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2002
Last sequence update:	June 1, 1998
Last modified:	December 16, 2008
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)