Reviewed, UniProtKB/Swiss-Prot O43795 (MYO1B_HUMAN)

Names and origin

Protein names

Recommended name:
    Myosin-Ib
Alternative name(s):
    Myosin I alpha
    MMI-alpha
      Short name=MMIa
    MYH-1c

Gene names

Name:

MYO1B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1136 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport By similarity.
Sequence similarities	Contains 6 IQ domains. Contains 1 myosin head-like domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	ATP-binding Actin-binding Calmodulin-binding Nucleotide-binding
Molecular function	Motor protein Myosin
Gene Ontology (GO)
Cellular component	myosin complex Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro actin binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BRF2	Q9HAW0	1	EBI-351119,EBI-1055224

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O43795-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O43795-2)

The sequence of this isoform differs from the canonical sequence as follows:
     795-852: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1136	1136	Myosin-Ib		PRO_0000123442
Regions
	Domain	17 – 688	672	Myosin head-like
	Domain	704 – 733	30	IQ 1
	Domain	728 – 748	21	IQ 2
	Domain	750 – 779	30	IQ 3
	Domain	779 – 808	30	IQ 4
	Domain	808 – 837	30	IQ 5
	Domain	837 – 866	30	IQ 6
Natural variations
	Alternative sequence	795 – 852	58	Missing in isoform 2.		VSP_012759
	Natural variant	385	1	V → G in a colorectal cancer sample; somatic mutation. Ref.3		VAR_036007
	Natural variant	385	1	V → I in a colorectal cancer sample; somatic mutation. Ref.3		VAR_036008
	Natural variant	969	1	E → K in a melanoma patient. Ref.2		VAR_014113

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 1, 2005. Version 3. Checksum: 98B7F2357928218D	FASTA	1,136	131,985
	10 20 30 40 50 60 MAKMEVKTSL LDNMIGVGDM VLLEPLNEET FINNLKKRFD HSEIYTYIGS VVISVNPYRS 70 80 90 100 110 120 LPIYSPEKVE EYRNRNFYEL SPHIFALSDE AYRSLRDQDK DQCILITGES GAGKTEASKL 130 140 150 160 170 180 VMSYVAAVCG KGAEVNQVKE QLLQSNPVLE AFGNAKTVRN DNSSRFGKYM DIEFDFKGDP 190 200 210 220 230 240 LGGVISNYLL EKSRVVKQPR GERNFHVFYQ LLSGASEELL NKLKLERDFS RYNYLSLDSA 250 260 270 280 290 300 KVNGVDDAAN FRTVRNAMQI VGFMDHEAES VLAVVAAVLK LGNIEFKPES RVNGLDESKI 310 320 330 340 350 360 KDKNELKEIC ELTGIDQSVL ERAFSFRTVE AKQEKVSTTL NVAQAYYARD ALAKNLYSRL 370 380 390 400 410 420 FSWLVNRINE SIKAQTKVRK KVMGVLDIYG FEIFEDNSFE QFIINYCNEK LQQIFIELTL 430 440 450 460 470 480 KEEQEEYIRE DIEWTHIDYF NNAIICDLIE NNTNGILAML DEECLRPGTV TDETFLEKLN 490 500 510 520 530 540 QVCATHQHFE SRMSKCSRFL NDTSLPHSCF RIQHYAGKVL YQVEGFVDKN NDLLYRDLSQ 550 560 570 580 590 600 AMWKASHALI KSLFPEGNPA KINLKRPPTA GSQFKASVAT LMKNLQTKNP NYIRCIKPND 610 620 630 640 650 660 KKAAHIFNEA LVCHQIRYLG LLENVRVRRA GYAFRQAYEP CLERYKMLCK QTWPHWKGPA 670 680 690 700 710 720 RSGVEVLFNE LEIPVEEYSF GRSKIFIRNP RTLFKLEDLR KQRLEDLATL IQKIYRGWKC 730 740 750 760 770 780 RTHFLLMKKS QIVIAAWYRR YAQQKRYQQT KSSALVIQSY IRGWKARKIL RELKHQKRCK 790 800 810 820 830 840 EAVTTIAAYW HGTQARRELR RLKEEARNKH AIAVIWAYWL GSKARRELKR LKEEARRKHA 850 860 870 880 890 900 VAVIWAYWLG LKVRREYRKF FRANAGKKIY EFTLQRIVQK YFLEMKNKMP SLSPIDKNWP 910 920 930 940 950 960 SRPYLFLDST HKELKRIFHL WRCKKYRDQF TDQQKLIYEE KLEASELFKD KKALYPSSVG 970 980 990 1000 1010 1020 QPFQGAYLEI NKNPKYKKLK DAIEEKIIIA EVVNKINRAN GKSTSRIFLL TNNNLLLADQ 1030 1040 1050 1060 1070 1080 KSGQIKSEVP LVDVTKVSMS SQNDGFFAVH LKEGSEAASK GDFLFSSDHL IEMATKLYRT 1090 1100 1110 1120 1130 TLSQTKQKLN IEISDEFLVQ FRQDKVCVKF IQGNQKNGSV PTCKRKNNRL LEVAVP
	Isoform 2. Checksum: D77952776D3EFDE5		1,078	124,951
	10 20 30 40 50 60 MAKMEVKTSL LDNMIGVGDM VLLEPLNEET FINNLKKRFD HSEIYTYIGS VVISVNPYRS 70 80 90 100 110 120 LPIYSPEKVE EYRNRNFYEL SPHIFALSDE AYRSLRDQDK DQCILITGES GAGKTEASKL 130 140 150 160 170 180 VMSYVAAVCG KGAEVNQVKE QLLQSNPVLE AFGNAKTVRN DNSSRFGKYM DIEFDFKGDP 190 200 210 220 230 240 LGGVISNYLL EKSRVVKQPR GERNFHVFYQ LLSGASEELL NKLKLERDFS RYNYLSLDSA 250 260 270 280 290 300 KVNGVDDAAN FRTVRNAMQI VGFMDHEAES VLAVVAAVLK LGNIEFKPES RVNGLDESKI 310 320 330 340 350 360 KDKNELKEIC ELTGIDQSVL ERAFSFRTVE AKQEKVSTTL NVAQAYYARD ALAKNLYSRL 370 380 390 400 410 420 FSWLVNRINE SIKAQTKVRK KVMGVLDIYG FEIFEDNSFE QFIINYCNEK LQQIFIELTL 430 440 450 460 470 480 KEEQEEYIRE DIEWTHIDYF NNAIICDLIE NNTNGILAML DEECLRPGTV TDETFLEKLN 490 500 510 520 530 540 QVCATHQHFE SRMSKCSRFL NDTSLPHSCF RIQHYAGKVL YQVEGFVDKN NDLLYRDLSQ 550 560 570 580 590 600 AMWKASHALI KSLFPEGNPA KINLKRPPTA GSQFKASVAT LMKNLQTKNP NYIRCIKPND 610 620 630 640 650 660 KKAAHIFNEA LVCHQIRYLG LLENVRVRRA GYAFRQAYEP CLERYKMLCK QTWPHWKGPA 670 680 690 700 710 720 RSGVEVLFNE LEIPVEEYSF GRSKIFIRNP RTLFKLEDLR KQRLEDLATL IQKIYRGWKC 730 740 750 760 770 780 RTHFLLMKKS QIVIAAWYRR YAQQKRYQQT KSSALVIQSY IRGWKARKIL RELKHQKRCK 790 800 810 820 830 840 EAVTTIAAYW HGTQVRREYR KFFRANAGKK IYEFTLQRIV QKYFLEMKNK MPSLSPIDKN 850 860 870 880 890 900 WPSRPYLFLD STHKELKRIF HLWRCKKYRD QFTDQQKLIY EEKLEASELF KDKKALYPSS 910 920 930 940 950 960 VGQPFQGAYL EINKNPKYKK LKDAIEEKII IAEVVNKINR ANGKSTSRIF LLTNNNLLLA 970 980 990 1000 1010 1020 DQKSGQIKSE VPLVDVTKVS MSSQNDGFFA VHLKEGSEAA SKGDFLFSSD HLIEMATKLY 1030 1040 1050 1060 1070 RTTLSQTKQK LNIEISDEFL VQFRQDKVCV KFIQGNQKNG SVPTCKRKNN RLLEVAVP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Skin.
[2]	"A mutated non conventional class I myosin peptide elicits a dominant CTL response in a regressive human primary melanoma lesion." Zorn E., Hercend T. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 644-1136 (ISOFORM 2), VARIANT LYS-969.
[3]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLY-385 AND ILE-385.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC053558 mRNA. Translation: AAH53558.1. AJ001381 mRNA. Translation: CAA04712.1. AJ001382 mRNA. Translation: CAA04713.1.
RefSeq	NP_001123630.1.
UniGene	Hs.439620
3D structure databases
HSSP	HSSP built from PDB template 1BR2 based on UniProtKB P10587.
ModBase	Search...
Protein-protein interaction databases
IntAct	O43795. 9 interactions.
PTM databases
PhosphoSite	O43795.
Proteomic databases
PRIDE	O43795.
Genome annotation databases
Ensembl	ENSG00000128641. Homo sapiens. [Contig view]
GeneID	4430.
KEGG	hsa:4430.
Organism-specific databases
GeneCards	GC02P191818.
HGNC	HGNC:7596. MYO1B.
HPA	HPA013607.
MIM	606537. gene.
PharmGKB	PA31398.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O43795.
HOVERGEN	O43795.
Gene expression databases
ArrayExpress	O43795.
CleanEx	HS_MYO1B.
Family and domain databases
InterPro	IPR000048. IQ_CaM_bd_region. IPR001609. Myosin_head. IPR010926. Myosin_tail_2. [Graphical view]
Pfam	PF00612. IQ. 3 hits. PF00063. Myosin_head. 1 hit. PF06017. Myosin_TH1. 1 hit. [Graphical view]
PRINTS	PR00193. MYOSINHEAVY.
ProDom	PD000355. Myosin_head. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00015. IQ. 6 hits. SM00242. MYSc. 1 hit. [Graphical view]
PROSITE	PS50096. IQ. 5 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	17273.
SOURCE	Search...

Entry information

Entry name

MYO1B_HUMAN

Accession

Primary (citable) accession number: O43795
Secondary accession number(s): O43794, Q7Z6L5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	February 1, 2005
Last modified:	December 16, 2008
This is version 75 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)