Reviewed, UniProtKB/Swiss-Prot O43913 (ORC5_HUMAN)

Names and origin

Protein names

Recommended name:
    Origin recognition complex subunit 5

Gene names

Name:

ORC5L

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	435 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner.
Subunit structure	ORC is composed of six subunits.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the ORC5 family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	ATP-binding Nucleotide-binding
Gene Ontology (GO)
Biological process	DNA replication initiation Ref.3 Traceable author statement. Source: ProtInc
Cellular component	nucleoplasm Inferred from Experiment. Source: Reactome
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Ref.3 Traceable author statement. Source: ProtInc identical protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		1	EBI-374928,EBI-374928
CDC45L	O75419	1	EBI-374928,EBI-374969
CDC6	Q99741	1	EBI-374928,EBI-374862
CDC7	O00311	1	EBI-374928,EBI-374980
CDKN2A	P42771	1	EBI-374928,EBI-375053
MCM2	P49736	1	EBI-374928,EBI-374819
MCM3	P25205	1	EBI-374928,EBI-355153
MCM5	P33992	1	EBI-374928,EBI-359410
ORC1L	Q13415	1	EBI-374928,EBI-374847
ORC2L	Q13416	1	EBI-374928,EBI-374957
ORC3L	Q9UBD5	1	EBI-374928,EBI-374916
ORC4L	O43929	1	EBI-374928,EBI-374889

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 435	435	Origin recognition complex subunit 5		PRO_0000127092
Regions
	Nucleotide binding	37 – 44	8	ATP Potential
Natural variations
	Natural variant	37	1	G → R: dbSNP rs1056677.		VAR_011800
	Natural variant	52	1	K → N: dbSNP rs2307413.		VAR_014524
	Natural variant	166	1	R → C: dbSNP rs2307402.		VAR_014525

Sequences

	Sequence		Length	Mass (Da)
	O43913-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 0FEB0E829C124745	FASTA	435	50,283
	10 20 30 40 50 60 MPHLENVVLC RESQVSILQS LFGERHHFSF PSIFIYGHTA SGKTYVTQTL LKTLELPHVF 70 80 90 100 110 120 VNCVECFTLR LLLEQILNKL NHLSSSEDGC STEITCETFN DFVRLFKQVT TAENLKDQTV 130 140 150 160 170 180 YIVLDKAEYL RDMEANLLPG FLRLQELADR NVTVLFLSEI VWEKFRPNTG CFEPFVLYFP 190 200 210 220 230 240 DYSIGNLQKI LSHDHPPEYS ADFYAAYINI LLGVFYTVCR DLKELRHLAV LNFPKYCEPV 250 260 270 280 290 300 VKGEASERDT RKLWRNIEPH LKKAMQTVYL REISSSQWEK LQKDDTDPGQ LKGLSAHTHV 310 320 330 340 350 360 ELPYYSKFIL IAAYLASYNP ARTDKRFFLK HHGKIKKTNF LKKHEKTSNH LLGPKPFPLD 370 380 390 400 410 420 RLLAILYSIV DSRVAPTANI FSQITSLVTL QLLTLVGHDD QLDGPKYKCT VSLDFIRAIA 430 RTVNFDIIKY LYDFL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p." Tugal T., Zou-Yang X.H., Gavin K., Pappin D., Canas B., Kobayashi R., Hunt T., Stillman B. J. Biol. Chem. 273:32421-32429(1998) [PubMed: 9829972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22." Ishiai M., Dean F.B., Okumura K., Abe M., Moon K.-Y., Amin A.A., Kagotani K., Taguchi H., Murakami Y., Hanaoka F., O'Donnell M., Hurwitz J., Eki T. Genomics 46:294-298(1997) [PubMed: 9417919] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases." Quintana D.G., Thome K.C., Hou Z.-H., Ligon A.H., Morton C.C., Dutta A. J. Biol. Chem. 273:27137-27145(1998) [PubMed: 9765232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF047599 mRNA. Translation: AAC80283.1. U92538 mRNA. Translation: AAC51933.1. AF049127 mRNA. Translation: AAC63972.1. BC023652 mRNA. Translation: AAH23652.1.
RefSeq	NP_002544.1.
UniGene	Hs.432948
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O43913. 12 interactions.
PTM databases
PhosphoSite	O43913.
Proteomic databases
PeptideAtlas	O43913.
PRIDE	O43913.
Genome annotation databases
Ensembl	ENSG00000164815. Homo sapiens. [Contig view]
GeneID	5001.
KEGG	hsa:5001.
Organism-specific databases
GeneCards	GC07M103554.
H-InvDB	HIX0025267.
HGNC	HGNC:8491. ORC5L.
MIM	602331. gene.
PharmGKB	PA32812.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O43913.
HOVERGEN	O43913.
Enzyme and pathway databases
Reactome	REACT_152. Cell Cycle, Mitotic. REACT_1538. Cell Cycle Checkpoints. REACT_383. DNA Replication.
Gene expression databases
ArrayExpress	O43913.
CleanEx	HS_ORC5L.
GermOnline	ENSG00000164815. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	19256.
SOURCE	Search...

Entry information

Entry name

ORC5_HUMAN

Accession

Primary (citable) accession number: O43913
Secondary accession number(s): O60590

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	June 1, 1998
Last modified:	December 16, 2008
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)