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Reviewed, UniProtKB/Swiss-Prot O43929 (ORC4_HUMAN)

Last modified December 16, 2008. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Origin recognition complex subunit 4
Gene names
Name: ORC4L
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner.

Subunit structure

ORC is composed of six subunits. Interacts with DBF4 By similarity.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the ORC4 family.

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Ontologies

Keywords

   Biological processDNA replication
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandATP-binding
DNA-binding
Nucleotide-binding

Gene Ontology (GO)

   Biological processDNA replication initiation Ref.1

Inferred from mutant phenotype. Source: UniProtKB

   Cellular componentnucleoplasm

Inferred from Experiment. Source: Reactome

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

DNA replication origin binding Ref.1

Inferred from mutant phenotype. Source: UniProtKB

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 436436Origin recognition complex subunit 4
PRO_0000127087

Regions

Nucleotide binding67 – 748ATP Potential

Natural variations

Natural variant561L → V: dbSNP rs2307397. Ref.4
VAR_014523
Natural variant781N → S: dbSNP rs2307394. Ref.1 Ref.2 Ref.3
VAR_019235

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Sequences

Sequence LengthMass (Da)Tools
O43929-1 [UniParc].

Last modified June 7, 2005. Version 2.
Checksum: A7020B6690E30B4E

FASTA43650,377
        10         20         30         40         50         60 
MSSRKSKSNS LIHTECLSQV QRILRERFCR QSPHSNLFGV QVQYKHLSEL LKRTALHGES 

        70         80         90        100        110        120 
NSVLIIGPRG SGKTMLINHA LKELMEIEEV SENVLQVHLN GLLQINDKIA LKEITRQLNL 

       130        140        150        160        170        180 
ENVVGDKVFG SFAENLSFLL EALKKGDRTS SCPVIFILDE FDLFAHHKNQ TLLYNLFDIS 

       190        200        210        220        230        240 
QSAQTPIAVI GLTCRLDILE LLEKRVKSRF SHRQIHLMNS FGFPQYVKIF KEQLSLPAEF 

       250        260        270        280        290        300 
PDKVFAEKWN ENVQYLSEDR SVQEVLQKHF NISKNLRSLH MLLMLALNRV TASHPFMTAV 

       310        320        330        340        350        360 
DLMEASQLCS MDSKANIVHG LSVLEICLII AMKHLNDIYE EEPFNFQMVY NEFQKFVQRK 

       370        380        390        400        410        420 
AHSVYNFEKP VVMKAFEHLQ QLELIKPMER TSGNSQREYQ LMKLLLDNTQ IMNALQKYPN 

       430 
CPTDVRQWAT SSLSWL

« Hide

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References

« Hide 'large scale' references
[1]"Identification of HsORC4, a member of the human origin of replication recognition complex."
Quintana D.G., Hou Z.H., Thome K.C., Hendricks M., Saha P., Dutta A.
J. Biol. Chem. 272:28247-28251(1997) [PubMed: 9353276] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-78.
[2]"The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p."
Komrskova T., Yang H., Gavin K., Pappin D., Canas B., Kobayashi R., Hunt T., Stillman B.
Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE, VARIANT SER-78.
[3]"cDNA cloning of a homolog for S. cerevisiae ORC4 from H. sapiens."
Dean F.B., O'Donnell M.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE, VARIANT SER-78.
[4]NIEHS SNPs program
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-56.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
+Additional computationally mapped references.

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Web resources

NIEHS-SNPs

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Cross-references

Sequence databases

AF022108 mRNA. Translation: AAC01957.1.
AF047598 mRNA. Translation: AAC80282.1.
AF132596 mRNA. Translation: AAD22110.1.
AY600302 Genomic DNA. Translation: AAS94326.1.
BC014847 mRNA. Translation: AAH14847.1.
RefSeqNP_002543.2.
NP_859525.1.
NP_859526.1.
UniGeneHs.558364

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActO43929. 9 interactions.

Proteomic databases

PeptideAtlasO43929.
PRIDEO43929.

Genome annotation databases

EnsemblENSG00000115947. Homo sapiens. [Contig view]
GeneID5000.
KEGGhsa:5000.

Organism-specific databases

GeneCardsGC02M148408.
H-InvDBHIX0002492.
HGNCHGNC:8490. ORC4L.
HPACAB015124.
MIM603056. gene.
PharmGKBPA32811.
GenAtlasSearch...

Phylogenomic databases

HOGENOMO43929.
HOVERGENO43929.

Enzyme and pathway databases

ReactomeREACT_152. Cell Cycle, Mitotic.
REACT_1538. Cell Cycle Checkpoints.
REACT_383. DNA Replication.

Gene expression databases

ArrayExpressO43929.
CleanExHS_ORC4L.
GermOnlineENSG00000115947. Homo sapiens.

Family and domain databases

InterProIPR003593. AAA+_ATPase_core.
IPR016527. Origin_recognition_cplx_su4.
[Graphical view]
PIRSFPIRSF007858. ORC4. 1 hit.
SMARTSM00382. AAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

LinkHubO43929.
NextBio19248.
SOURCESearch...

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Entry information

Entry nameORC4_HUMAN
AccessionPrimary (citable) accession number: O43929
Secondary accession number(s): Q96C42
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 7, 2005
Last modified: December 16, 2008
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents