Reviewed, UniProtKB/Swiss-Prot O46341 (A6_DROME)

Names and origin

Protein names

Recommended name:
    Protein a6

Gene names

Name:	a6
ORF Names:	CG3771

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	409 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Developmental stage

Expressed throughout embryogenesis.

Ontologies

Keywords
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	embryonic development via the syncytial blastoderm Ref.1 Inferred from expression pattern. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q9VFM3	1	EBI-170846,EBI-134330
	Q9VQ30	1	EBI-170846,EBI-93669
	Q9VZX3	1	EBI-170846,EBI-145651
	Q9W3T3	1	EBI-170846,EBI-147517

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 409	409	Protein a6
Amino acid modifications
	Modified residue	86	1	Phosphoserine
	Modified residue	133	1	Phosphothreonine
	Modified residue	134	1	Phosphoserine

Sequences

	Sequence		Length	Mass (Da)
	O46341-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 46FA1A9F93D391AB	FASTA	409	44,077
	10 20 30 40 50 60 MNQKHSEPFY ISPRLFDNRR LKRRRCRWME RLLEHQRICM ARMRDQVALA SKTDRQLSHL 70 80 90 100 110 120 QRRHVASTLQ PDVTIDLLSD DDETPSAGQP AAAGHNRLLI PAPGHRAHRT GRRQAPRRAA 130 140 150 160 170 180 THSYPVTDSI LITSDDEHNE QEPSSTARVR SQLSMRSPPP LAPLTQSETI EEVTVSLVPR 190 200 210 220 230 240 TSTTANCLTR VSGHPKPCRA STAASNGFAT AEGGEGGNET GCFLEVDVGG GITATLPDET 250 260 270 280 290 300 TVHTVIANRI YELSLSKLRE GLAFSGVPEY TNDLMPEQLQ KLSPALRAKV APLVAPSPPT 310 320 330 340 350 360 PISLKLSSDL SISLISDEDD CESTGPHVNG GVGTEPVHPV VVAAAEAHAA AKLLKQQQPQ 370 380 390 400 LSVVQHLQYV GGGLAAPVAL ALPVMAANPT SSASVVALPL QLPRRRKLG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparison of the molecular and genetic map of the 2B6-2B7-8 of Drosophila melanogaster X-chromosome." Makunin I.V., Shestopal S.A., Beliaeva E.S., Ashburner M., Khimulev I.F. Genetika 35:1071-1077(1999) [PubMed: 10546111] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: Oregon-RC. Tissue: Larva.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[4]	"From sequence to chromosome: the tip of the X chromosome of D. melanogaster." Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G., Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Borkova D., Minana B. , Kafatos F.C., Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L., Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P., Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H., Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S., McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C., Glover D.M. Science 287:2220-2222(2000) [PubMed: 10731137] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Oregon-R.
[5]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
[6]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86; THR-133 AND SER-134, MASS SPECTROMETRY. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y16065 Genomic DNA. Translation: CAA76017.1. Y16066 mRNA. Translation: CAA76018.1. AE014298 Genomic DNA. Translation: AAF45661.2. AL031025 Genomic DNA. Translation: CAA19836.1. AY069426 mRNA. Translation: AAL39571.1.
RefSeq	NP_477309.1.
UniGene	Dm.2135
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:19729N.
IntAct	O46341.
Genome annotation databases
Ensembl	CG3771. Drosophila melanogaster. [Contig view]
GeneID	31127.
KEGG	dme:Dmel_CG3771.
NMPDR	fig|7227.3.peg.16099.
Organism-specific databases
FlyBase	FBgn0023130. a6.
Phylogenomic databases
HOGENOM	O46341.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-000223-MON.
Gene expression databases
ArrayExpress	O46341.
GermOnline	CG3771. Drosophila melanogaster.
Family and domain databases
ProDom	O46341. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

A6_DROME

Accession

Primary (citable) accession number: O46341
Secondary accession number(s): Q9W564

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	June 1, 1998
Last modified:	July 22, 2008
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project