Reviewed, UniProtKB/Swiss-Prot O50630 (IF1_BACHD)

Names and origin

Protein names

Recommended name:
    Translation initiation factor IF-1

Gene names

Name:	infA
Ordered Locus Names:	BH0158

Organism

Bacillus halodurans [Complete proteome] [HAMAP]

Taxonomic identifier

86665 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	72 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	No specific function has so far been attributed to this initiation factor; however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3. HAMAP MF_00075
Subcellular location	Cytoplasm. HAMAP MF_00075
Sequence similarities	Belongs to the IF-1 family. Contains 1 S1-like domain.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Molecular function	Initiation factor
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translational initiation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	RNA binding Inferred from electronic annotation. Source: HAMAP translation initiation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 72	71	Translation initiation factor IF-1 HAMAP MF_00075		PRO_0000095734
Regions
	Domain	2 – 72	71	S1-like
Amino acid modifications
	Modified residue	60	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O50630-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: BEB0533F2D47D28F	FASTA	72	8,293
	10 20 30 40 50 60 MAKEDVIEVE GTVIEPLPNA MFRVELENGH KILAHVSGKI RMHFIRILPG DKVTVELSPY 70 DLTRGRITYR YK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of the gene encoding RNA polymerase alpha subunit from alkaliphilic Bacillus sp. strain C-125." Nakasone K., Takaki Y., Takami H., Inoue A., Horikoshi K. FEMS Microbiol. Lett. 168:269-276(1998) [PubMed: 9835038] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.
[2]	"Sequence analysis of a 32-kb region including the major ribosomal protein gene clusters from alkaliphilic Bacillus sp. strain C-125." Takami H., Takaki Y., Nakasone K., Hirama C., Inoue A., Horikoshi K. Biosci. Biotechnol. Biochem. 63:452-455(1999) [PubMed: 10192928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.
[3]	"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB010082 Genomic DNA. Translation: BAA24190.1. AB017508 Genomic DNA. Translation: BAA75294.1. BA000004 Genomic DNA. Translation: BAB03877.1.
PIR	T44406.
RefSeq	NP_241024.1.
3D structure databases
HSSP	HSSP built from PDB template 1AH9 based on UniProtKB P02998.
SMR	O50630. Positions 2-72.
ModBase	Search...
Genome annotation databases
GeneID	893591.
GenomeReviews	Gene locus BH0158 in contig BA000004_GR.
KEGG	bha:BH0158.
NMPDR	fig|272558.1.peg.158.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O50630.
Enzyme and pathway databases
BioCyc	BHAL272558:BH0158-MON.
Family and domain databases
HAMAP	MF_00075. [Tree]
InterPro	IPR006196. S1_IF1. IPR003029. S1_RNA-bd. IPR004368. TIF_IF1. [Graphical view]
Pfam	PF01176. eIF-1a. 1 hit. [Graphical view]
SMART	SM00316. S1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00008. infA. 1 hit.
PROSITE	PS50832. S1_IF1_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IF1_BACHD

Accession

Primary (citable) accession number: O50630

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 23, 2007
Last modified:	November 4, 2008
This is version 59 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)