true
2001-01-24
2008-07-22
75
CATS_MOUSE
Cathepsin S
Doh-ura K.
1998-03
EMBL/GenBank/DDBJ
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
129/Sv
BALB/c
Brain
Rommerskirch W.
1997-11
EMBL/GenBank/DDBJ
NUCLEOTIDE SEQUENCE [MRNA]
Spleen
Cathepsin expression during skeletal development.
Soederstroem M.
Salminen H.
Glumoff V.
Kirschke H.
Aro H.
Vuorio E.
1999
Biochim. Biophys. Acta
1446
35-46
NUCLEOTIDE SEQUENCE [MRNA] OF 144-306
TISSUE SPECIFICITY
C57BL/6
Cartilage
Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts.
Dandoy-Dron F.
Guillo F.
Benboudjema L.
Deslys J.-P.
Lasmesas C.
Dormont D.
Tovey M.G.
Dron M.
doi:10.1074/jbc.273.13.7691
1998
J. Biol. Chem.
273
7691-7697
NUCLEOTIDE SEQUENCE [MRNA] OF 296-340
C57BL/6
Brain
Ctss
Cats
Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.
Widely expressed with highest expression found in non-skeletal tissues. Relatively high levels found in skeletal tissues.
Belongs to the peptidase C1 family.
1
17
Activation peptide
18
122
Cathepsin S
123
340
147
147
287
287
307
307
N-linked (GlcNAc...)
120
120
134
134
233
233
144
144
189
189
178
178
222
222
281
281
329
329
M
218
218
MAVLDAPGVLCGNGATAER
1
29
H
34
34
L
97
97
P
106
106
S
146
146
30
40
48
74
78
81
87
89
91
97
110
115
129
132
147
164
172
178
182
185
194
204
207
209
210
212
226
228
229
231
244
253
257
261
266
269
271
276
288
298
301
307
311
313
319
323
325
328
329
331
EMBL
EMBL
EMBL
EMBL
EMBL
UniGene
PDB
A=1-340
PDBsum
SMR
26-340
MEROPS
Ensembl
Mus musculus
MGI
Ctss
HOVERGEN
BindingDB
ArrayExpress
CleanEx
GermOnline
Mus musculus
InterPro
Pept_cys_AS
InterPro
Peptidase_C1A
InterPro
Peptidase_C1A_C
InterPro
Prot_inhib_I29
PANTHER
Peptidase_C1A
1
Pfam
Inhibitor_I29
1
Pfam
Peptidase_C1
1
PRINTS
PAPAIN
ProDom
Peptidase_C1
1
SMART
Pept_C1
1
PROSITE
THIOL_PROTEASE_ASN
1
PROSITE
THIOL_PROTEASE_CYS
1
PROSITE
THIOL_PROTEASE_HIS
1
MGI
MGI
MGI
MGI
1998-08-01
1
true
38438
MRAPGHAAIR WLFWMPLVCS VAMEQLQRDP TLDYHWDLWK KTHEKEYKDK NEEEVRRLIW EKNLKFIMIH NLEYSMGMHT YQVGMNDMGD MTNEEISCRM GALRISRQSP KTVTFRSYSN RTLPDTVDWR EKGCVTEVKY QGSCGACWAF SAVGALEGQL KLKTGKLISL SAQNLVDCSN EEKYGNKGCG GGYMTEAFQY IIDNGGIEAD ASYPYKATDE KCHYNSKNRA ATCSRYIQLP FGDEDALKEA VATKGPVSVG IDASHSSFFF YKSGVYDDPS CTGNVNHGVL VVGYGTLDGK DYWLVKNSWG LNFGDQGYIR MARNNKNHCG IASYCSYPEI