Reviewed, UniProtKB/Swiss-Prot O75179 (ANR17_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat domain-containing protein 17
Alternative name(s):
    Gene trap ankyrin repeat protein
    Serologically defined breast cancer antigen NY-BR-16

Gene names

Name:	ANKRD17
Synonyms:	GTAR, KIAA0697

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2603 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Earliest specific in situ marker of hepatic differentiation during embryogenesis, useful for characterization of inductive events involved in hepatic specification By similarity. Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease).
Subunit structure	Interacts with VP1 capsid protein of enterovirus 71 (EV71).
Subcellular location	Cytoplasm. Nucleus. Note= Detected around the nucleolus.
Tissue specificity	Expressed in bone marrow.
Sequence similarities	Contains 25 ANK repeats. Contains 1 KH domain.
Sequence caution	The sequence AAG48253.1 differs from that shown. Reason: Frameshift at several positions. The sequence AAH04173.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence. The sequence AAH04891.1 differs from that shown. Reason: Erroneous translation. The sequence AAH04891.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence. The sequence BAB15260.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB15260.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Biological process	Host-virus interaction
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	ANK repeat Coiled coil Repeat
Ligand	RNA-binding
PTM	Phosphoprotein
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75179-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75179-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1028-1028: Missing.

Isoform 3 (identifier: O75179-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1176-1187: KEHRNVSDYTPL → YRSTGMVLITHL
     1188-2603: Missing.

Notes: No experimental confirmation available.

Isoform 4 (identifier: O75179-4)

The sequence of this isoform differs from the canonical sequence as follows:
     982-1010: GVIVGQPVLGQAQLAGLGQGILTETQQGL → VLSSLLQPCFLSTLPLILMHRLRVIMTRR
     1011-1603: Missing.

Notes: No experimental confirmation available.

Isoform 5 (identifier: O75179-5)

The sequence of this isoform differs from the canonical sequence as follows:
     742-751: NRAPRVPVQA → TDNIFPRLVC
     752-2603: Missing.

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 2603	2603	Ankyrin repeat domain-containing protein 17
Regions
	Repeat	233 – 262	30	ANK 1
	Repeat	266 – 295	30	ANK 2
	Repeat	300 – 329	30	ANK 3
	Repeat	333 – 362	30	ANK 4
	Repeat	366 – 395	30	ANK 5
	Repeat	400 – 429	30	ANK 6
	Repeat	433 – 462	30	ANK 7
	Repeat	466 – 495	30	ANK 8
	Repeat	499 – 528	30	ANK 9
	Repeat	533 – 562	30	ANK 10
	Repeat	563 – 592	30	ANK 11
	Repeat	596 – 625	30	ANK 12
	Repeat	629 – 658	30	ANK 13
	Repeat	663 – 692	30	ANK 14
	Repeat	696 – 725	30	ANK 15
	Repeat	1082 – 1111	30	ANK 16
	Repeat	1115 – 1144	30	ANK 17
	Repeat	1149 – 1178	30	ANK 18
	Repeat	1182 – 1211	30	ANK 19
	Repeat	1217 – 1246	30	ANK 20
	Repeat	1251 – 1280	30	ANK 21
	Repeat	1284 – 1313	30	ANK 22
	Repeat	1319 – 1348	30	ANK 23
	Repeat	1352 – 1381	30	ANK 24
	Repeat	1385 – 1414	30	ANK 25
	Domain	1725 – 1789	65	KH
	Coiled coil	1442 – 1526	85	Potential
	Compositional bias	96 – 110	15	Gly-rich
	Compositional bias	858 – 1008	151	Gln-rich
	Compositional bias	1603 – 1700	98	Ser-rich
	Compositional bias	1950 – 2106	157	Ser-rich
	Compositional bias	1966 – 2033	68	Thr-rich
Amino acid modifications
	Modified residue	1333	1	Phosphotyrosine
	Modified residue	2042	1	Phosphoserine
	Modified residue	2045	1	Phosphoserine
	Modified residue	2047	1	Phosphoserine
	Modified residue	2059	1	Phosphoserine
	Modified residue	2067	1	Phosphoserine
Natural variations
	Alternative sequence	742 – 751	10	NRAPRVPVQA → TDNIFPRLVC in isoform 5.
	Alternative sequence	752 – 2603	1852	Missing in isoform 5.
	Alternative sequence	982 – 1010	29	GVIVG…TQQGL → VLSSLLQPCFLSTLPLILMH RLRVIMTRR in isoform 4.
	Alternative sequence	1011 – 1603	593	Missing in isoform 4.
	Alternative sequence	1028	1	Missing in isoform 2.
	Alternative sequence	1176 – 1187	12	KEHRN…DYTPL → YRSTGMVLITHL in isoform 3.
	Alternative sequence	1188 – 2603	1416	Missing in isoform 3.
	Natural variant	2560	1	H → Y: dbSNP rs2306059.
Experimental info
	Sequence conflict	304	1	P → S in BAA31672. Ref.4
	Sequence conflict	705	1	A → P in AAG48253. Ref.1
	Sequence conflict	713	1	V → G in AAG48253. Ref.1
	Sequence conflict	1137	1	D → G in BAB15260. Ref.7
	Sequence conflict	1163	1	Q → P in AAG48253. Ref.1
	Sequence conflict	1391	1	Missing in CAD38571. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 23, 2007. Version 3. Checksum: BD2BF51889283483	FASTA	2,603	274,258
	10 20 30 40 50 60 MEKATVPVAA ATAAEGEGSP PAVAAVAGPP AAAEVGGGVG GSSRARSASS PRGMVRVCDL 70 80 90 100 110 120 LLKKKPPQQQ HHKAKRNRTC RPPSSSESSS DSDNSGGGGG GGGGGGGGGG TSSNNSEEEE 130 140 150 160 170 180 DDDDEEEEVS EVESFILDQD DLENPMLETA SKLLLSGTAD GADLRTVDPE TQARLEALLE 190 200 210 220 230 240 AAGIGKLSTA DGKAFADPEV LRRLTSSVSC ALDEAAAALT RMRAESTANA GQSDNRSLAE 250 260 270 280 290 300 ACSEGDVNAV RKLLIEGRSV NEHTEEGESL LCLACSAGYY ELAQVLLAMH ANVEDRGIKG 310 320 330 340 350 360 DITPLMAAAN GGHVKIVKLL LAHKADVNAQ SSTGNTALTY ACAGGYVDVV KVLLESGASI 370 380 390 400 410 420 EDHNENGHTP LMEAGSAGHV EVARLLLENG AGINTHSNEF KESALTLACY KGHLEMVRFL 430 440 450 460 470 480 LEAGADQEHK TDEMHTALME ACMDGHVEVA RLLLDSGAQV NMPADSFESP LTLAACGGHV 490 500 510 520 530 540 ELAALLIERG ASLEEVNDEG YTPLMEAARE GHEEMVALLL GQGANINAQT EETQETALTL 550 560 570 580 590 600 ACCGGFLEVA DFLIKAGADI ELGCSTPLME AAQEGHLELV KYLLAAGANV HATTATGDTA 610 620 630 640 650 660 LTYACENGHT DVADVLLQAG ADLEHESEGG RTPLMKAARA GHVCTVQFLI SKGANVNRTT 670 680 690 700 710 720 ANNDHTVLSL ACAGGHLAVV ELLLAHGADP THRLKDGSTM LIEAAKGGHT SVVCYLLDYP 730 740 750 760 770 780 NNLLSAPPPD VTQLTPPSHD LNRAPRVPVQ ALPMVVPPQE PDKPPANVAT TLPIRNKAAS 790 800 810 820 830 840 KQKSSSHLPA NSQDVQGYIT NQSPESIVEE AQGKLTELEQ RIKEAIEKNA QLQSLELAHA 850 860 870 880 890 900 DQLTKEKIEE LNKTREEQIQ KKQKILEELQ KVERELQLKT QQQLKKQYLE VKAQRIQLQQ 910 920 930 940 950 960 QQQQSCQHLG LLTPVGVGEQ LSEGDYARLQ QVDPVLLKDE PQQTAAQMGF APIQPLAMPQ 970 980 990 1000 1010 1020 ALPLAAGPLP PGSIANLTEL QGVIVGQPVL GQAQLAGLGQ GILTETQQGL MVASPAQTLN 1030 1040 1050 1060 1070 1080 DTLDDIMAAV SGRASAMSNT PTHSIAASIS QPQTPTPSPI ISPSAMLPIY PAIDIDAQTE 1090 1100 1110 1120 1130 1140 SNHDTALTLA CAGGHEELVQ TLLERGASIE HRDKKGFTPL ILAATAGHVG VVEILLDNGA 1150 1160 1170 1180 1190 1200 DIEAQSERTK DTPLSLACSG GRQEVVELLL ARGANKEHRN VSDYTPLSLA ASGGYVNIIK 1210 1220 1230 1240 1250 1260 ILLNAGAEIN SRTGSKLGIS PLMLAAMNGH TAAVKLLLDM GSDINAQIET NRNTALTLAC 1270 1280 1290 1300 1310 1320 FQGRTEVVSL LLDRKANVEH RAKTGLTPLM EAASGGYAEV GRVLLDKGAD VNAPPVPSSR 1330 1340 1350 1360 1370 1380 DTALTIAADK GHYKFCELLI GRGAHIDVRN KKGNTPLWLA ANGGHLDVVQ LLVQAGADVD 1390 1400 1410 1420 1430 1440 AADNRKITPL MAAFRKGHVK VVRYLVKEVN QFPSDSECMR YIATITDKEM LKKCHLCMES 1450 1460 1470 1480 1490 1500 IVQAKDRQAA EANKNASILL EELDLEKLRE ESRRLALAAK REKRKEKRRK KKEEQRRKLE 1510 1520 1530 1540 1550 1560 EIEAKNKENF ELQAAQEKEK LKVEDEPEVL TEPPSATTTT TIGISATWTT LAGSHGKRNN 1570 1580 1590 1600 1610 1620 TITTTSSKRK NRKNKITPEN VQIIFDDPLP ISYSQPEKVN GESKSSSTSE SGDSDNMRIS 1630 1640 1650 1660 1670 1680 SCSDESSNSN SSRKSDNHSP AVVTTTVSSK KQPSVLVTFP KEERKSVSGK ASIKLSETIS 1690 1700 1710 1720 1730 1740 EGTSNSLSTC TKSGPSPLSS PNGKLTVASP KRGQKREEGW KEVVRRSKKV SVPSTVISRV 1750 1760 1770 1780 1790 1800 IGRGGCNINA IREFTGAHID IDKQKDKTGD RIITIRGGTE STRQATQLIN ALIKDPDKEI 1810 1820 1830 1840 1850 1860 DELIPKNRLK SSSANSKIGS SAPTTTAANT SLMGIKMTTV ALSSTSQTAT ALTVPAISSA 1870 1880 1890 1900 1910 1920 STHKTIKNPV NNVRPGFPVS LPLAYPPPQF AHALLAAQTF QQIRPPRLPM THFGGTFPPA 1930 1940 1950 1960 1970 1980 QSTWGPFPVR PLSPARATNS PKPHMVPRHS NQNSSGSQVN SAGSLTSSPT TTTSSSASTV 1990 2000 2010 2020 2030 2040 PGTSTNGSPS SPSVRRQLFV TVVKTSNATT TTVTTTASNN NTAPTNATYP MPTAKEHYPV 2050 2060 2070 2080 2090 2100 SSPSSPSPPA QPGGVSRNSP LDCGSASPNK VASSSEQEAG SPPVVETTNT RPPNSSSSSG 2110 2120 2130 2140 2150 2160 SSSAHSNQQQ PPGSVSQEPR PPLQQSQVPP PEVRMTVPPL ATSSAPVAVP STAPVTYPMP 2170 2180 2190 2200 2210 2220 QTPMGCPQPT PKMETPAIRP PPHGTTAPHK NSASVQNSSV AVLSVNHIKR PHSVPSSVQL 2230 2240 2250 2260 2270 2280 PSTLSTQSAC QNSVHPANKP IAPNFSAPLP FGPFSTLFEN SPTSAHAFWG GSVVSSQSTP 2290 2300 2310 2320 2330 2340 ESMLSGKSSY LPNSDPLHQS DTSKAPGFRP PLQRPAPSPS GIVNMDSPYG SVTPSSTHLG 2350 2360 2370 2380 2390 2400 NFASNISGGQ MYGPGAPLGG APAAANFNRQ HFSPLSLLTP CSSASNDSSA QSVSSGVRAP 2410 2420 2430 2440 2450 2460 SPAPSSVPLG SEKPSNVSQD RKVPVPIGTE RSARIRQTGT SAPSVIGSNL STSVGHSGIW 2470 2480 2490 2500 2510 2520 SFEGIGGNQD KVDWCNPGMG NPMIHRPMSD PGVFSQHQAM ERDSTGIVTP SGTFHQHVPA 2530 2540 2550 2560 2570 2580 GYMDFPKVGG MPFSVYGNAM IPPVAPIPDG AGGPIFNGPH AADPSWNSLI KMVSSSTENN 2590 2600 GPQTVWTGPW APHMNSVHMN QLG
	Isoform 2 [UniParc]. Checksum: F446818E5B8ED6FB		2,602	274,187
	10 20 30 40 50 60 MEKATVPVAA ATAAEGEGSP PAVAAVAGPP AAAEVGGGVG GSSRARSASS PRGMVRVCDL 70 80 90 100 110 120 LLKKKPPQQQ HHKAKRNRTC RPPSSSESSS DSDNSGGGGG GGGGGGGGGG TSSNNSEEEE 130 140 150 160 170 180 DDDDEEEEVS EVESFILDQD DLENPMLETA SKLLLSGTAD GADLRTVDPE TQARLEALLE 190 200 210 220 230 240 AAGIGKLSTA DGKAFADPEV LRRLTSSVSC ALDEAAAALT RMRAESTANA GQSDNRSLAE 250 260 270 280 290 300 ACSEGDVNAV RKLLIEGRSV NEHTEEGESL LCLACSAGYY ELAQVLLAMH ANVEDRGIKG 310 320 330 340 350 360 DITPLMAAAN GGHVKIVKLL LAHKADVNAQ SSTGNTALTY ACAGGYVDVV KVLLESGASI 370 380 390 400 410 420 EDHNENGHTP LMEAGSAGHV EVARLLLENG AGINTHSNEF KESALTLACY KGHLEMVRFL 430 440 450 460 470 480 LEAGADQEHK TDEMHTALME ACMDGHVEVA RLLLDSGAQV NMPADSFESP LTLAACGGHV 490 500 510 520 530 540 ELAALLIERG ASLEEVNDEG YTPLMEAARE GHEEMVALLL GQGANINAQT EETQETALTL 550 560 570 580 590 600 ACCGGFLEVA DFLIKAGADI ELGCSTPLME AAQEGHLELV KYLLAAGANV HATTATGDTA 610 620 630 640 650 660 LTYACENGHT DVADVLLQAG ADLEHESEGG RTPLMKAARA GHVCTVQFLI SKGANVNRTT 670 680 690 700 710 720 ANNDHTVLSL ACAGGHLAVV ELLLAHGADP THRLKDGSTM LIEAAKGGHT SVVCYLLDYP 730 740 750 760 770 780 NNLLSAPPPD VTQLTPPSHD LNRAPRVPVQ ALPMVVPPQE PDKPPANVAT TLPIRNKAAS 790 800 810 820 830 840 KQKSSSHLPA NSQDVQGYIT NQSPESIVEE AQGKLTELEQ RIKEAIEKNA QLQSLELAHA 850 860 870 880 890 900 DQLTKEKIEE LNKTREEQIQ KKQKILEELQ KVERELQLKT QQQLKKQYLE VKAQRIQLQQ 910 920 930 940 950 960 QQQQSCQHLG LLTPVGVGEQ LSEGDYARLQ QVDPVLLKDE PQQTAAQMGF APIQPLAMPQ 970 980 990 1000 1010 1020 ALPLAAGPLP PGSIANLTEL QGVIVGQPVL GQAQLAGLGQ GILTETQQGL MVASPAQTLN 1030 1040 1050 1060 1070 1080 DTLDDIMAVS GRASAMSNTP THSIAASISQ PQTPTPSPII SPSAMLPIYP AIDIDAQTES 1090 1100 1110 1120 1130 1140 NHDTALTLAC AGGHEELVQT LLERGASIEH RDKKGFTPLI LAATAGHVGV VEILLDNGAD 1150 1160 1170 1180 1190 1200 IEAQSERTKD TPLSLACSGG RQEVVELLLA RGANKEHRNV SDYTPLSLAA SGGYVNIIKI 1210 1220 1230 1240 1250 1260 LLNAGAEINS RTGSKLGISP LMLAAMNGHT AAVKLLLDMG SDINAQIETN RNTALTLACF 1270 1280 1290 1300 1310 1320 QGRTEVVSLL LDRKANVEHR AKTGLTPLME AASGGYAEVG RVLLDKGADV NAPPVPSSRD 1330 1340 1350 1360 1370 1380 TALTIAADKG HYKFCELLIG RGAHIDVRNK KGNTPLWLAA NGGHLDVVQL LVQAGADVDA 1390 1400 1410 1420 1430 1440 ADNRKITPLM AAFRKGHVKV VRYLVKEVNQ FPSDSECMRY IATITDKEML KKCHLCMESI 1450 1460 1470 1480 1490 1500 VQAKDRQAAE ANKNASILLE ELDLEKLREE SRRLALAAKR EKRKEKRRKK KEEQRRKLEE 1510 1520 1530 1540 1550 1560 IEAKNKENFE LQAAQEKEKL KVEDEPEVLT EPPSATTTTT IGISATWTTL AGSHGKRNNT 1570 1580 1590 1600 1610 1620 ITTTSSKRKN RKNKITPENV QIIFDDPLPI SYSQPEKVNG ESKSSSTSES GDSDNMRISS 1630 1640 1650 1660 1670 1680 CSDESSNSNS SRKSDNHSPA VVTTTVSSKK QPSVLVTFPK EERKSVSGKA SIKLSETISE 1690 1700 1710 1720 1730 1740 GTSNSLSTCT KSGPSPLSSP NGKLTVASPK RGQKREEGWK EVVRRSKKVS VPSTVISRVI 1750 1760 1770 1780 1790 1800 GRGGCNINAI REFTGAHIDI DKQKDKTGDR IITIRGGTES TRQATQLINA LIKDPDKEID 1810 1820 1830 1840 1850 1860 ELIPKNRLKS SSANSKIGSS APTTTAANTS LMGIKMTTVA LSSTSQTATA LTVPAISSAS 1870 1880 1890 1900 1910 1920 THKTIKNPVN NVRPGFPVSL PLAYPPPQFA HALLAAQTFQ QIRPPRLPMT HFGGTFPPAQ 1930 1940 1950 1960 1970 1980 STWGPFPVRP LSPARATNSP KPHMVPRHSN QNSSGSQVNS AGSLTSSPTT TTSSSASTVP 1990 2000 2010 2020 2030 2040 GTSTNGSPSS PSVRRQLFVT VVKTSNATTT TVTTTASNNN TAPTNATYPM PTAKEHYPVS 2050 2060 2070 2080 2090 2100 SPSSPSPPAQ PGGVSRNSPL DCGSASPNKV ASSSEQEAGS PPVVETTNTR PPNSSSSSGS 2110 2120 2130 2140 2150 2160 SSAHSNQQQP PGSVSQEPRP PLQQSQVPPP EVRMTVPPLA TSSAPVAVPS TAPVTYPMPQ 2170 2180 2190 2200 2210 2220 TPMGCPQPTP KMETPAIRPP PHGTTAPHKN SASVQNSSVA VLSVNHIKRP HSVPSSVQLP 2230 2240 2250 2260 2270 2280 STLSTQSACQ NSVHPANKPI APNFSAPLPF GPFSTLFENS PTSAHAFWGG SVVSSQSTPE 2290 2300 2310 2320 2330 2340 SMLSGKSSYL PNSDPLHQSD TSKAPGFRPP LQRPAPSPSG IVNMDSPYGS VTPSSTHLGN 2350 2360 2370 2380 2390 2400 FASNISGGQM YGPGAPLGGA PAAANFNRQH FSPLSLLTPC SSASNDSSAQ SVSSGVRAPS 2410 2420 2430 2440 2450 2460 PAPSSVPLGS EKPSNVSQDR KVPVPIGTER SARIRQTGTS APSVIGSNLS TSVGHSGIWS 2470 2480 2490 2500 2510 2520 FEGIGGNQDK VDWCNPGMGN PMIHRPMSDP GVFSQHQAME RDSTGIVTPS GTFHQHVPAG 2530 2540 2550 2560 2570 2580 YMDFPKVGGM PFSVYGNAMI PPVAPIPDGA GGPIFNGPHA ADPSWNSLIK MVSSSTENNG 2590 2600 PQTVWTGPWA PHMNSVHMNQ LG
	Isoform 3 [UniParc]. Checksum: A0D3DD0135B33F07		1,187	124,637
	10 20 30 40 50 60 MEKATVPVAA ATAAEGEGSP PAVAAVAGPP AAAEVGGGVG GSSRARSASS PRGMVRVCDL 70 80 90 100 110 120 LLKKKPPQQQ HHKAKRNRTC RPPSSSESSS DSDNSGGGGG GGGGGGGGGG TSSNNSEEEE 130 140 150 160 170 180 DDDDEEEEVS EVESFILDQD DLENPMLETA SKLLLSGTAD GADLRTVDPE TQARLEALLE 190 200 210 220 230 240 AAGIGKLSTA DGKAFADPEV LRRLTSSVSC ALDEAAAALT RMRAESTANA GQSDNRSLAE 250 260 270 280 290 300 ACSEGDVNAV RKLLIEGRSV NEHTEEGESL LCLACSAGYY ELAQVLLAMH ANVEDRGIKG 310 320 330 340 350 360 DITPLMAAAN GGHVKIVKLL LAHKADVNAQ SSTGNTALTY ACAGGYVDVV KVLLESGASI 370 380 390 400 410 420 EDHNENGHTP LMEAGSAGHV EVARLLLENG AGINTHSNEF KESALTLACY KGHLEMVRFL 430 440 450 460 470 480 LEAGADQEHK TDEMHTALME ACMDGHVEVA RLLLDSGAQV NMPADSFESP LTLAACGGHV 490 500 510 520 530 540 ELAALLIERG ASLEEVNDEG YTPLMEAARE GHEEMVALLL GQGANINAQT EETQETALTL 550 560 570 580 590 600 ACCGGFLEVA DFLIKAGADI ELGCSTPLME AAQEGHLELV KYLLAAGANV HATTATGDTA 610 620 630 640 650 660 LTYACENGHT DVADVLLQAG ADLEHESEGG RTPLMKAARA GHVCTVQFLI SKGANVNRTT 670 680 690 700 710 720 ANNDHTVLSL ACAGGHLAVV ELLLAHGADP THRLKDGSTM LIEAAKGGHT SVVCYLLDYP 730 740 750 760 770 780 NNLLSAPPPD VTQLTPPSHD LNRAPRVPVQ ALPMVVPPQE PDKPPANVAT TLPIRNKAAS 790 800 810 820 830 840 KQKSSSHLPA NSQDVQGYIT NQSPESIVEE AQGKLTELEQ RIKEAIEKNA QLQSLELAHA 850 860 870 880 890 900 DQLTKEKIEE LNKTREEQIQ KKQKILEELQ KVERELQLKT QQQLKKQYLE VKAQRIQLQQ 910 920 930 940 950 960 QQQQSCQHLG LLTPVGVGEQ LSEGDYARLQ QVDPVLLKDE PQQTAAQMGF APIQPLAMPQ 970 980 990 1000 1010 1020 ALPLAAGPLP PGSIANLTEL QGVIVGQPVL GQAQLAGLGQ GILTETQQGL MVASPAQTLN 1030 1040 1050 1060 1070 1080 DTLDDIMAAV SGRASAMSNT PTHSIAASIS QPQTPTPSPI ISPSAMLPIY PAIDIDAQTE 1090 1100 1110 1120 1130 1140 SNHDTALTLA CAGGHEELVQ TLLERGASIE HRDKKGFTPL ILAATAGHVG VVEILLDNGA 1150 1160 1170 1180 DIEAQSERTK DTPLSLACSG GRQEVVELLL ARGANYRSTG MVLITHL
	Isoform 4 [UniParc]. Checksum: CAF01D3CC80C50E5		2,010	210,593
	10 20 30 40 50 60 MEKATVPVAA ATAAEGEGSP PAVAAVAGPP AAAEVGGGVG GSSRARSASS PRGMVRVCDL 70 80 90 100 110 120 LLKKKPPQQQ HHKAKRNRTC RPPSSSESSS DSDNSGGGGG GGGGGGGGGG TSSNNSEEEE 130 140 150 160 170 180 DDDDEEEEVS EVESFILDQD DLENPMLETA SKLLLSGTAD GADLRTVDPE TQARLEALLE 190 200 210 220 230 240 AAGIGKLSTA DGKAFADPEV LRRLTSSVSC ALDEAAAALT RMRAESTANA GQSDNRSLAE 250 260 270 280 290 300 ACSEGDVNAV RKLLIEGRSV NEHTEEGESL LCLACSAGYY ELAQVLLAMH ANVEDRGIKG 310 320 330 340 350 360 DITPLMAAAN GGHVKIVKLL LAHKADVNAQ SSTGNTALTY ACAGGYVDVV KVLLESGASI 370 380 390 400 410 420 EDHNENGHTP LMEAGSAGHV EVARLLLENG AGINTHSNEF KESALTLACY KGHLEMVRFL 430 440 450 460 470 480 LEAGADQEHK TDEMHTALME ACMDGHVEVA RLLLDSGAQV NMPADSFESP LTLAACGGHV 490 500 510 520 530 540 ELAALLIERG ASLEEVNDEG YTPLMEAARE GHEEMVALLL GQGANINAQT EETQETALTL 550 560 570 580 590 600 ACCGGFLEVA DFLIKAGADI ELGCSTPLME AAQEGHLELV KYLLAAGANV HATTATGDTA 610 620 630 640 650 660 LTYACENGHT DVADVLLQAG ADLEHESEGG RTPLMKAARA GHVCTVQFLI SKGANVNRTT 670 680 690 700 710 720 ANNDHTVLSL ACAGGHLAVV ELLLAHGADP THRLKDGSTM LIEAAKGGHT SVVCYLLDYP 730 740 750 760 770 780 NNLLSAPPPD VTQLTPPSHD LNRAPRVPVQ ALPMVVPPQE PDKPPANVAT TLPIRNKAAS 790 800 810 820 830 840 KQKSSSHLPA NSQDVQGYIT NQSPESIVEE AQGKLTELEQ RIKEAIEKNA QLQSLELAHA 850 860 870 880 890 900 DQLTKEKIEE LNKTREEQIQ KKQKILEELQ KVERELQLKT QQQLKKQYLE VKAQRIQLQQ 910 920 930 940 950 960 QQQQSCQHLG LLTPVGVGEQ LSEGDYARLQ QVDPVLLKDE PQQTAAQMGF APIQPLAMPQ 970 980 990 1000 1010 1020 ALPLAAGPLP PGSIANLTEL QVLSSLLQPC FLSTLPLILM HRLRVIMTRR KSSSTSESGD 1030 1040 1050 1060 1070 1080 SDNMRISSCS DESSNSNSSR KSDNHSPAVV TTTVSSKKQP SVLVTFPKEE RKSVSGKASI 1090 1100 1110 1120 1130 1140 KLSETISEGT SNSLSTCTKS GPSPLSSPNG KLTVASPKRG QKREEGWKEV VRRSKKVSVP 1150 1160 1170 1180 1190 1200 STVISRVIGR GGCNINAIRE FTGAHIDIDK QKDKTGDRII TIRGGTESTR QATQLINALI 1210 1220 1230 1240 1250 1260 KDPDKEIDEL IPKNRLKSSS ANSKIGSSAP TTTAANTSLM GIKMTTVALS STSQTATALT 1270 1280 1290 1300 1310 1320 VPAISSASTH KTIKNPVNNV RPGFPVSLPL AYPPPQFAHA LLAAQTFQQI RPPRLPMTHF 1330 1340 1350 1360 1370 1380 GGTFPPAQST WGPFPVRPLS PARATNSPKP HMVPRHSNQN SSGSQVNSAG SLTSSPTTTT 1390 1400 1410 1420 1430 1440 SSSASTVPGT STNGSPSSPS VRRQLFVTVV KTSNATTTTV TTTASNNNTA PTNATYPMPT 1450 1460 1470 1480 1490 1500 AKEHYPVSSP SSPSPPAQPG GVSRNSPLDC GSASPNKVAS SSEQEAGSPP VVETTNTRPP 1510 1520 1530 1540 1550 1560 NSSSSSGSSS AHSNQQQPPG SVSQEPRPPL QQSQVPPPEV RMTVPPLATS SAPVAVPSTA 1570 1580 1590 1600 1610 1620 PVTYPMPQTP MGCPQPTPKM ETPAIRPPPH GTTAPHKNSA SVQNSSVAVL SVNHIKRPHS 1630 1640 1650 1660 1670 1680 VPSSVQLPST LSTQSACQNS VHPANKPIAP NFSAPLPFGP FSTLFENSPT SAHAFWGGSV 1690 1700 1710 1720 1730 1740 VSSQSTPESM LSGKSSYLPN SDPLHQSDTS KAPGFRPPLQ RPAPSPSGIV NMDSPYGSVT 1750 1760 1770 1780 1790 1800 PSSTHLGNFA SNISGGQMYG PGAPLGGAPA AANFNRQHFS PLSLLTPCSS ASNDSSAQSV 1810 1820 1830 1840 1850 1860 SSGVRAPSPA PSSVPLGSEK PSNVSQDRKV PVPIGTERSA RIRQTGTSAP SVIGSNLSTS 1870 1880 1890 1900 1910 1920 VGHSGIWSFE GIGGNQDKVD WCNPGMGNPM IHRPMSDPGV FSQHQAMERD STGIVTPSGT 1930 1940 1950 1960 1970 1980 FHQHVPAGYM DFPKVGGMPF SVYGNAMIPP VAPIPDGAGG PIFNGPHAAD PSWNSLIKMV 1990 2000 2010 SSSTENNGPQ TVWTGPWAPH MNSVHMNQLG
	Isoform 5 [UniParc]. Checksum: 391CFA8C368A3895		751	77,825
	10 20 30 40 50 60 MEKATVPVAA ATAAEGEGSP PAVAAVAGPP AAAEVGGGVG GSSRARSASS PRGMVRVCDL 70 80 90 100 110 120 LLKKKPPQQQ HHKAKRNRTC RPPSSSESSS DSDNSGGGGG GGGGGGGGGG TSSNNSEEEE 130 140 150 160 170 180 DDDDEEEEVS EVESFILDQD DLENPMLETA SKLLLSGTAD GADLRTVDPE TQARLEALLE 190 200 210 220 230 240 AAGIGKLSTA DGKAFADPEV LRRLTSSVSC ALDEAAAALT RMRAESTANA GQSDNRSLAE 250 260 270 280 290 300 ACSEGDVNAV RKLLIEGRSV NEHTEEGESL LCLACSAGYY ELAQVLLAMH ANVEDRGIKG 310 320 330 340 350 360 DITPLMAAAN GGHVKIVKLL LAHKADVNAQ SSTGNTALTY ACAGGYVDVV KVLLESGASI 370 380 390 400 410 420 EDHNENGHTP LMEAGSAGHV EVARLLLENG AGINTHSNEF KESALTLACY KGHLEMVRFL 430 440 450 460 470 480 LEAGADQEHK TDEMHTALME ACMDGHVEVA RLLLDSGAQV NMPADSFESP LTLAACGGHV 490 500 510 520 530 540 ELAALLIERG ASLEEVNDEG YTPLMEAARE GHE