Reviewed, UniProtKB/Swiss-Prot O75348 (VATG1_HUMAN)

Names and origin

Protein names

Recommended name:
    Vacuolar proton pump subunit G 1
    EC=3.6.3.14
Alternative name(s):
    V-ATPase subunit G 1
    V-ATPase 13 kDa subunit 1
    Vacuolar proton pump subunit M16

Gene names

Name:	ATP6V1G1
Synonyms:	ATP6G, ATP6G1, ATP6J

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	118 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Catalytic activity	ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).
Subunit structure	V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).
Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the V-ATPase G subunit family.

Ontologies

Keywords
Biological process	Hydrogen ion transport Ion transport Transport
Molecular function	Hydrolase
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 118	117	Vacuolar proton pump subunit G 1
Amino acid modifications
	Modified residue	2	1	N-acetylalanine

Sequences

	Sequence		Length	Mass (Da)
	O75348-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: A289C1B96634E34C	FASTA	118	13,758
	10 20 30 40 50 60 MASQSQGIQQ LLQAEKRAAE KVSEARKRKN RRLKQAKEEA QAEIEQYRLQ REKEFKAKEA 70 80 90 100 110 AALGSRGSCS TEVEKETQEK MTILQTYFRQ NRDEVLDNLL AFVCDIRPEI HENYRING

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning." Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z. Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed: 9653160] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skeletal muscle.
[3]	Kanor S., Bienvenut W.V., Quadroni M. Submitted (DEC-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-16; 38-48 AND 81-89, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, MASS SPECTROMETRY. Tissue: Melanoma.
[4]	"Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis." Smith A.N., Borthwick K.J., Karet F.E. Gene 297:169-177(2002) [PubMed: 12384298] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF038954 mRNA. Translation: AAC39868.1. BC008452 mRNA. Translation: AAH08452.1.
RefSeq	NP_004879.1.
UniGene	Hs.388654
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O75348.
Proteomic databases
PeptideAtlas	O75348.
Genome annotation databases
Ensembl	ENSG00000136888. Homo sapiens. [Contig view]
GeneID	9550.
KEGG	hsa:9550.
Organism-specific databases
H-InvDB	HIX0020553.
HGNC	HGNC:864. ATP6V1G1.
HPA	CAB004615.
MIM	607296. gene.
PharmGKB	PA25163.
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOGENOM	O75348.
HOVERGEN	O75348.
Gene expression databases
ArrayExpress	O75348.
CleanEx	HS_ATP6V1G1.
GermOnline	ENSG00000136888. Homo sapiens.
Family and domain databases
InterPro	IPR005124. V-ATPase_G. [Graphical view]
PANTHER	PTHR12713. V-ATPase_G. 1 hit.
Pfam	PF03179. V-ATPase_G. 1 hit. [Graphical view]
TIGRFAMs	TIGR01147. V_ATP_synt_G. 1 hit.
ProDom	O75348. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
LinkHub	O75348.
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

VATG1_HUMAN

Accession

Primary (citable) accession number: O75348

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 23, 2007
Last modified:	July 22, 2008
This is version 70 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)