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Reviewed, UniProtKB/Swiss-Prot O75410 (TACC1_HUMAN)

Last modified December 16, 2008. Version 77. Feed History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Transforming acidic coiled-coil-containing protein 1
Alternative name(s):
    Taxin 1
    Gastric cancer antigen Ga55
Gene names
Name: TACC1
Synonyms: KIAA1103
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length805 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

Subunit structure

Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with the Aurora kinases A and B (STK6 and AURKB). Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF. Ref.9 Ref.10 Ref.11 Ref.12 Ref.13

Subcellular location

Cytoplasm. Nucleus. Note= Nucleus during interphase. Weakly concentrated at centrosomes during mitosis. Ref.12

Tissue specificity

Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Ref.10 Ref.7

Developmental stage

Expressed at high level during early embryogenesis.

Post-translational modification

Isoform 1 is heavily phosphorylated; isoform 6 is not. Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.10 Ref.14 Ref.15 Ref.16

Miscellaneous

Down-regulated in a subset of cases of breast cancer.

Sequence similarities

Belongs to the TACC family.

Contains 2 SPAZ (Ser/Pro-rich AZU-1) domains.

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Ontologies

Keywords

   Biological processCell cycle
Cell division
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Repeat
   PTMPhosphoprotein

Gene Ontology (GO)

   Biological processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

cell division

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

nucleus

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionprotein binding Ref.9 Ref.10 Ref.11 Ref.13

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Notes: Additional isoforms seem to exist.
Isoform 1 (identifier: O75410-1)

Also known as: A; Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O75410-2)

Also known as: F;

The sequence of this isoform differs from the canonical sequence as follows:
     464-464: T → TTTEQVKFLCFLL
Isoform 3 (identifier: O75410-3)

Also known as: E;

The sequence of this isoform differs from the canonical sequence as follows:
     1-195: Missing.
Isoform 4 (identifier: O75410-4)

Also known as: D;

The sequence of this isoform differs from the canonical sequence as follows:
     1-426: Missing.
     427-464: DPFKPTTTLT...PKKAKSRLIT → MGGSHSQTPR...EQVKFLCFLL
Isoform 5 (identifier: O75410-5)

Also known as: C;

The sequence of this isoform differs from the canonical sequence as follows:
     1-438: Missing.
     439-464: DFCSPTGNHVNEILESPKKAKSRLIT → MGGSHSQTPRGREPAGERHPRPTETA
Isoform 6 (identifier: O75410-6)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: S → R
     55-464: Missing.
Isoform 7 (identifier: O75410-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.
     42-53: EDSQAETKSLSF → MNNILKLK
     525-553: Missing.
Isoform 8 (identifier: O75410-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-651: Missing.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 805805Transforming acidic coiled-coil-containing protein 1
PRO_0000179986

Regions

Domain215 – 29783SPAZ 1
Domain359 – 507149SPAZ 2
Region1 – 5555Interaction with LSM7 and SNRPG
Region152 – 259108Interaction with TDRD7
Region206 – 427222Interaction with YEATS4
Region701 – 805105Interaction with CH-TOG
Coiled coil610 – 805196
Motif226 – 24116Bipartite nuclear localization signal 1 Potential
Motif455 – 47117Bipartite nuclear localization signal 2 Potential

Amino acid modifications

Modified residue441Phosphoserine Ref.16
Modified residue501Phosphoserine Ref.15
Modified residue521Phosphoserine Ref.15
Modified residue541Phosphoserine Ref.15
Modified residue551Phosphoserine Ref.15
Modified residue571Phosphoserine Ref.15
Modified residue5331Phosphotyrosine Ref.14

Natural variations

Alternative sequence1 – 651651Missing in isoform 8.
VSP_012640
Alternative sequence1 – 438438Missing in isoform 5.
VSP_012639
Alternative sequence1 – 426426Missing in isoform 4.
VSP_012641
Alternative sequence1 – 195195Missing in isoform 3.
VSP_012638
Alternative sequence1 – 4141Missing in isoform 7.
VSP_012637
Alternative sequence42 – 5312EDSQA…KSLSF → MNNILKLK in isoform 7.
VSP_012643
Alternative sequence541S → R in isoform 6.
VSP_012644
Alternative sequence55 – 464410Missing in isoform 6.
VSP_012645
Alternative sequence427 – 46438DPFKP…SRLIT → MGGSHSQTPRGREPAGERHP RPTETATTEQVKFLCFLL in isoform 4.
VSP_012642
Alternative sequence439 – 46426DFCSP…SRLIT → MGGSHSQTPRGREPAGERHP RPTETA in isoform 5.
VSP_012646
Alternative sequence4641T → TTTEQVKFLCFLL in isoform 2.
VSP_012647
Alternative sequence525 – 55329Missing in isoform 7.
VSP_012648
Natural variant1871P → L: dbSNP rs34235313.
VAR_053703
Natural variant2431I → T: dbSNP rs6980553.
VAR_053704
Natural variant2551E → G: dbSNP rs10107016.
VAR_053705

Experimental info

Sequence conflict2911L → I in AAC32327. Ref.1
Sequence conflict4281P → H in AAH41391. Ref.4
Sequence conflict5881G → V in BAA83055. Ref.5
Sequence conflict6541Missing in BAA83055. Ref.5

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (A) (Long) [UniParc].

Last modified February 1, 2005. Version 2.
Checksum: 3A261EF58C165107

FASTA80587,794
        10         20         30         40         50         60 
MAFSPWQILS PVQWAKWTWS AVRGGAAGED EAGGPEGDPE EEDSQAETKS LSFSSDSEGN 

        70         80         90        100        110        120 
FETPEAETPI RSPFKESCDP SLGLAGPGAK SQESQEADEQ LVAEVVEKCS SKTCSKPSEN 

       130        140        150        160        170        180 
EVPQQAIDSH SVKNFREEPE HDFSKISIVR PFSIETKDST DISAVLGTKA AHGCVTAVSG 

       190        200        210        220        230        240 
KALPSSPPDA LQDEAMTEGS MGVTLEASAE ADLKAGNSCP ELVPSRRSKL RKPKPVPLRK 

       250        260        270        280        290        300 
KAIGGEFSDT NAAVEGTPLP KASYHFSPEE LDENTSPLLG DARFQKSPPD LKETPGTLSS 

       310        320        330        340        350        360 
DTNDSGVELG EESRSSPLKL EFDFTEDTGN IEARKALPRK LGRKLGSTLT PKIQKDGISK 

       370        380        390        400        410        420 
SAGLEQPTDP VARDGPLSQT SSKPDPSQWE SPSFNPFGSH SVLQNSPPLS SEGSYHFDPD 

       430        440        450        460        470        480 
NFDESMDPFK PTTTLTSSDF CSPTGNHVNE ILESPKKAKS RLITSGCKVK KHETQSLALD 

       490        500        510        520        530        540 
ACSRDEGAVI SQISDISNRD GHATDEEKLA STSCGQKSAG AEVKGEPEED LEYFECSNVP 

       550        560        570        580        590        600 
VSTINHAFSS SEAGIEKETC QKMEEDGSTV LGLLESSAEK APVSVSCGGE SPLDGICLSE 

       610        620        630        640        650        660 
SDKTAVLTLI REEIITKEIE ANEWKKKYEE TRQEVLEMRK IVAEYEKTIA QMIEDEQRTS 

       670        680        690        700        710        720 
MTSQKSFQQL TMEKEQALAD LNSVERSLSD LFRRYENLKG VLEGFKKNEE ALKKCAQDYL 

       730        740        750        760        770        780 
ARVKQEEQRY QALKIHAEEK LDKANEEIAQ VRTKAKAESA ALHAGLRKEQ MKVESLERAL 

       790        800 
QQKNQEIEEL TKICDELIAK LGKTD

« Hide

Isoform 2 (F).

Checksum: B9D4BDE7B742E813
Show »

81789,218
Isoform 3 (E).

Checksum: 802527D4B613A881
Show »

61067,073
Isoform 4 (D).

Checksum: A3CF1029DF65E860
Show »

37942,326
Isoform 5 (C).

Checksum: F1761EA28D5AB9A8
Show »

36740,903
Isoform 6 (Short).

Checksum: B29F0EA1DCAAF8E1
Show »

39543,984
Isoform 7.

Checksum: 385263AECC0C7060
Show »

73179,872
Isoform 8.

Checksum: F7CF945C5A3E277D
Show »

15417,815

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References

« Hide 'large scale' references
[1]"Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon."
Still I.H., Hamilton M., Vince P., Wolfman A., Cowell J.K.
Oncogene 18:4032-4038(1999) [PubMed: 10435627] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms."
Still I.H., Vettaikkorumakankauv A.K., DiMatteo A., Liang P.
BMC Evol. Biol. 4:16-16(2004) [PubMed: 15207008] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
[3]"Cloning of a novel human gene similar to TACC1."
Li F., Yao K.T.
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8).
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
Tissue: Brain.
[5]"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:197-205(1999) [PubMed: 10470851] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 364-805 (ISOFORM 2).
Tissue: Brain.
[6]"Serological identification and expression analysis of gastric cancer-associated genes."
Line A., Stengrevics A., Slucka Z., Li G., Jankevics E., Rees R.C.
Br. J. Cancer 86:1824-1830(2002) [PubMed: 12087473] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 450-805 (ISOFORM 2).
Tissue: Gastric adenocarcinoma.
[7]"Altered splicing pattern of TACC1 mRNA in gastric cancer."
Line A., Slucka Z., Stengrevics A., Li G., Rees R.C.
Cancer Genet. Cytogenet. 139:78-83(2002) [PubMed: 12547166] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-543 (ISOFORM 3), NUCLEOTIDE SEQUENCE OF 1-571 (ISOFORMS 4 AND 5), TISSUE SPECIFICITY.
Tissue: Stomach cancer.
[8]"The TACC domain identifies a family of centrosomal proteins that can interact with microtubules."
Gergely F., Karlsson C., Still I.H., Cowell J.K., Kilmartin J., Raff J.W.
Proc. Natl. Acad. Sci. U.S.A. 97:14352-14357(2000) [PubMed: 11121038] [Abstract]
Cited for: CHARACTERIZATION.
Tissue: Brain, Fetal brain and Skeletal muscle.
[9]"Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells."
Lauffart B., Howell S.J., Tasch J.E., Cowell J.K., Still I.H.
Biochem. J. 363:195-200(2002) [PubMed: 11903063] [Abstract]
Cited for: INTERACTION WITH KIAA0097 AND YEATS4.
[10]"Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators."
Conte N., Charafe-Jauffret E., Delaval B., Adelaide J., Ginestier C., Geneix J., Isnardon D., Jacquemier J., Birnbaum D.
Oncogene 21:5619-5630(2002) [PubMed: 12165861] [Abstract]
Cited for: INTERACTION WITH LSM7 AND SNRPG, TISSUE SPECIFICITY, PHOSPHORYLATION.
[11]"TACC1-chTOG-Aurora A protein complex in breast cancer."
Conte N., Delaval B., Ginestier C., Ferrand A., Isnardon D., Larroque C., Prigent C., Seraphin B., Jacquemier J., Birnbaum D.
Oncogene 22:8102-8116(2003) [PubMed: 14603251] [Abstract]
Cited for: INTERACTION WITH KIAA0097; LSM7; TDRD7 AND STK6.
[12]"The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases."
Gangisetty O., Lauffart B., Sondarva G.V., Chelsea D.M., Still I.H.
Oncogene 23:2559-2563(2004) [PubMed: 14767476] [Abstract]
Cited for: INTERACTION WITH GCN5L2 AND PCAF, SUBCELLULAR LOCATION.
[13]"Aurora B -TACC1 protein complex in cytokinesis."
Delaval B., Ferrand A., Conte N., Larroque C., Hernandez-Verdun D., Prigent C., Birnbaum D.
Oncogene 23:4516-4522(2004) [PubMed: 15064709] [Abstract]